H3-4 - H3.4 histone, cluster member Gene

中文名称：H3.4 组蛋白，簇成员

种属: Homo sapiens

同用名: H3t; H3.4; H3/g; H3FT; H3C16; HIST3H3

关于 H3-4

功能概要

组蛋白是基本的核蛋白，负责真核生物染色体纤维的核小体结构。核小体由大约 146 bp 的 DNA 组成，包裹在由四种核心组蛋白 (H2A、H2B、H3 和 H4) 中的每一种成对组成的组蛋白八聚体周围。染色质纤维通过接头组蛋白 H1 与核小体之间的 DNA 相互作用进一步压缩，形成更高阶的染色质结构。该基因是无内含子的，编码复制依赖组蛋白，该组蛋白是组蛋白 H3 家族的成员。该基因的转录本缺少 polyA 尾巴；相反，它们包含回文终止元素。该基因与染色体 6p22-p21.3 组蛋白基因簇中的其他 H3 基因分开定位。[RefSeq 提供，2015 年 8 月]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is located separately from the other H3 genes that are in the histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]