1. Gene
  2. INCENP - inner centromere protein Gene

INCENP - inner centromere protein Gene

中文名称:内部着丝粒蛋白

种属: Homo sapiens

基因 ID: 3619 | 基因类型: protein coding

关于 INCENP

Cytogenetic location: 11q12.3 Genomic coordinates (GRCh38): 11:62,124,011-62,153,169 (from NCBI)

This gene has 6 transcripts (splice variants) and 207 orthologues. Ubiquitous expression in bone marrow (RPKM 6.2), esophagus (RPKM 5.2) and 24 other tissues.

功能概要

在哺乳动物细胞中,已描述了两大类着丝粒相互作用蛋白:组成型结合着丝粒蛋白和“乘客”或瞬时相互作用蛋白 (Choo 综述,1997) 。组成蛋白包括 CENPA (着丝粒蛋白 A;MIM 117139) 、CENPB (MIM 117140) 、CENPC1 (MIM 117141) 和 CENPD (MIM 117142) 。术语“乘客蛋白”涵盖了广泛的蛋白质集合,这些蛋白质在细胞周期的特定阶段定位于着丝粒 (Earnshaw 和 Mackay,1994 [PubMed 8088460]) 。其中包括 CENPE (MIM 117143) ; MCAK (MIM 604538) ;儿童 (MIM 603213) ;细胞质动力蛋白 (例如 MIM 600112) ;剪辑 (例如 MIM 179838) ;和 CENPF/核分裂激素 (MIM 600236) 。内部着丝粒蛋白 (INCENPs) (Earnshaw 和 Cooke,1991 [PubMed 1860899]) 是乘客蛋白组的初始成员,在有丝分裂的早期阶段沿染色体广泛定位,但随着细胞周期逐渐集中在着丝粒进展到中中期。在末期,蛋白质位于细胞间桥的中间体内,在胞质分裂后被丢弃 (Cutts 等人,1999 [PubMed 10369859]) 。[OMIM 提供,2008 年 3 月]

In mammalian cells, 2 broad groups of centromere-interacting proteins have been described: constitutively binding centromere proteins and 'passenger,' or transiently interacting, proteins (reviewed by Choo, 1997). The constitutive proteins include CENPA (centromere protein A; MIM 117139), CENPB (MIM 117140), CENPC1 (MIM 117141), and CENPD (MIM 117142). The term 'passenger proteins' encompasses a broad collection of proteins that localize to the centromere during specific stages of the cell cycle (Earnshaw and Mackay, 1994 [PubMed 8088460]). These include CENPE (MIM 117143); MCAK (MIM 604538); KID (MIM 603213); cytoplasmic dynein (e.g., MIM 600112); CliPs (e.g., MIM 179838); and CENPF/mitosin (MIM 600236). The inner centromere proteins (INCENPs) (Earnshaw and Cooke, 1991 [PubMed 1860899]), the initial members of the passenger protein group, display a broad localization along chromosomes in the early stages of mitosis but gradually become concentrated at centromeres as the cell cycle progresses into mid-metaphase. During telophase, the proteins are located within the midbody in the intercellular bridge, where they are discarded after cytokinesis (Cutts et al., 1999 [PubMed 10369859]).[supplied by OMIM, Mar 2008]

INCENP 基因产物(2)

mRNA Protein Name
NM_001040694.2 NP_001035784.1 inner centromere protein isoform 1
NM_020238.3 NP_064623.2 inner centromere protein isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables molecular function activator activity IPI
IPI: 通过物理相互作用推断
27332895 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
9864353 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in chromosome segregation IMP
IMP: 通过突变表型推断
16239925 GOA
involved in mitotic cytokinesis IMP
IMP: 通过突变表型推断
16239925 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of chromosome passenger complex IPI
IPI: 通过物理相互作用推断
17956729 GOA
located in chromosome, centromeric region IDA
IDA: 通过直接分析推断
11084331 GOA
located in kinetochore IDA
IDA: 通过直接分析推断
16760428 GOA
located in microtubule cytoskeleton IDA
IDA: 通过直接分析推断
9859993 GOA
located in pericentric heterochromatin IDA
IDA: 通过直接分析推断
9864353 GOA
part of protein-containing complex IDA
IDA: 通过直接分析推断
16239925 GOA
located in spindle IDA
IDA: 通过直接分析推断
9864353 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

INCENP 蛋白结构

INCENP_N

INCENP_N: Chromosome passenger complex (CPC) protein INCENP N terminal (5 - 42)

INCENP_ARK-bind

INCENP_ARK-bind: Inner centromere protein, ARK binding region (825 - 883)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 918 a.a.
蛋白主名 其他名称

inner centromere protein

binds and activates aurora-B and -C in vivo and in vitro

INCENP 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra INCENP Q9NQS7 H2BC21 Homo sapiens Q16778
Crosslink
30021884
Intra INCENP Q9NQS7 AURKC Homo sapiens Q9UQB9
Pull Down
27332895
Intra INCENP Q9NQS7 BIRC5 Homo sapiens O15392
PLA
21051298
Intra INCENP Q9NQS7 BIRC5 Homo sapiens O15392
Anti Tag CoIP
17956729
Intra INCENP Q9NQS7 BIRC5 Homo sapiens O15392
Anti Tag CoIP
17099693
Intra INCENP Q9NQS7 BIRC5 Homo sapiens O15392
Anti Bait CoIP
16239925
Intra INCENP Q9NQS7 BIRC5 Homo sapiens O15392
Pull Down
17099693
Intra INCENP Q9NQS7 AURKB Homo sapiens Q96GD4
Anti Tag CoIP
20562864
Intra INCENP Q9NQS7 AURKB Homo sapiens Q96GD4
Anti Bait CoIP
21346195
Intra INCENP Q9NQS7 AURKB Homo sapiens Q96GD4
Anti Tag CoIP
17956729
Intra INCENP Q9NQS7 AURKB Homo sapiens Q96GD4
Pull Down
27332895
Intra INCENP Q9NQS7 AURKB Homo sapiens Q96GD4
Anti Bait CoIP
16239925
Intra INCENP Q9NQS7 AURKB Homo sapiens Q96GD4
Anti Tag CoIP
27332895
Intra INCENP Q9NQS7 CBX5 Homo sapiens P45973
Anti Tag CoIP
20562864
Intra INCENP Q9NQS7 CBX5 Homo sapiens P45973
Y2H
9864353
Intra INCENP Q9NQS7 CBX5 Homo sapiens P45973
Anti Tag CoIP
21346195
Intra INCENP Q9NQS7 CBX5 Homo sapiens P45973
IF
21346195
Intra INCENP Q9NQS7 CBX5 Homo sapiens P45973
Anti Bait CoIP
21346195
Intra INCENP Q9NQS7 CBX5 Homo sapiens P45973
Pull Down
9864353
Intra INCENP Q9NQS7 CBX5 Homo sapiens P45973
Y2H
20562864
Intra INCENP Q9NQS7 CDCA8 Homo sapiens Q53HL2
Anti Tag CoIP
17956729
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Nephronophthisis

Medullary Cystic Disease

Medullary Cystic Kidney

Nph

Nphp

Kidney Disease, Cystic, Medullary

Juvenile Nephronophthisis

Nephronophthisis

Nephronophthisis, Familial Juvenile

Cholestasis, Intrahepatic, Of Pregnancy, 1

ICP1

Intrahepatic Cholestasis Of Pregnancy 1

Cholestasis, Pregnancy-Related, 1

Pregnancy Related Cholestasis 1

Cholestasis Of Pregnancy, Intrahepatic 1

Obstetric Cholestasis

Pregnancy-Related Cholestasis

Recurrent Intrahepatic Cholestasis Of Pregnancy

Cholestasis, Intrahepatic, Of Pregnancy, Type 1

Cholestasis Of Pregnancy

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Canis familiaris INCENP VGNC VGNC:42016
Mus musculus INCENP MGD MGI:1313288
Bos taurus INCENP VGNC VGNC:106783
Rattus norvegicus INCENP RGD RGD:1305292
Macaca mulatta INCENP VGNC VGNC:73741
Felis catus INCENP VGNC VGNC:67801
Others INCENP NCBI