2. Gene
  3. AURKC - aurora kinase C Gene

AURKC - aurora kinase C Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：极光激酶 C

种属: Homo sapiens

同用名: AIE2; AIK3; ARK3; AurC; SPGF5; STK13; HEL-S-90; aurora-C

基因 ID: 6795 | 基因类型: protein coding

关于 AURKC

Cytogenetic location: 19q13.43 Genomic coordinates (GRCh38): 19:57,231,023-57,235,548 (from NCBI)

This gene has 7 transcripts (splice variants), 99 orthologues, 2 paralogues and is associated with 2 phenotypes. Biased expression in testis (RPKM 14.8), brain (RPKM 1.0) and 1 other tissue.

功能概要

该基因编码丝氨酸/苏氨酸蛋白激酶的 Aurora 亚家族成员。编码的蛋白质是一种染色体过客蛋白，与 Aurora-B 和内部着丝粒蛋白形成复合物，并可能在组织有丝分裂过程中与中心体/纺锤体功能相关的微管中发挥作用。该基因在几种癌细胞系中过度表达，表明参与致癌信号转导。可变剪接导致多个转录本变体。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the Aurora subfamily of serine/threonine protein kinases. The encoded protein is a chromosomal passenger protein that forms complexes with Aurora-B and inner centromere proteins and may play a role in organizing microtubules in relation to centrosome/spindle function during mitosis. This gene is overexpressed in several Cancer cell lines, suggesting an involvement in oncogenic signal transduction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]

AURKC 基因产物(4)

mRNA Protein Name
NM_001015878.2 NP_001015878.1 aurora kinase C isoform 1
NM_001015879.2 NP_001015879.1 aurora kinase C isoform 2
NM_003160.3 NP_003151.2 aurora kinase C isoform 3
XM_047439253.1 XP_047295209.1 aurora kinase C isoform X1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
21988832 GOA
enables protein kinase activity IDA
IDA: 通过直接分析推断
15670791 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in protein phosphorylation IDA
IDA: 通过直接分析推断
15670791 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in condensed chromosome IDA
IDA: 通过直接分析推断
15670791 GOA
located in midbody IDA
IDA: 通过直接分析推断
15670791 GOA
located in spindle midzone IDA
IDA: 通过直接分析推断
15670791 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

AURKC 蛋白结构

Pkinase

Pkinase: Protein kinase domain (43 - 293)

  • 0
  • 100
  • 200
  • 309 a.a.
蛋白主名 其他名称

aurora kinase C

ARK-3

aurora 3

aurora-related kinase 3

aurora/IPL1-related kinase 3

aurora/IPL1/EG2 protein 2

epididymis secretory protein Li 90

serine/threonine kinase 13 (aurora/IPL1-like)

serine/threonine-protein kinase 13

serine/threonine-protein kinase aurora-C

AURKC 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra AURKC Q9UQB9 CADPS Homo sapiens A2RRN7
Y2H Array
32296183
Intra AURKC Q9UQB9 CADPS Homo sapiens A2RRN7
Y2H Prey Pooling
32296183
Intra AURKC Q9UQB9 INCENP Homo sapiens Q9NQS7
Pull Down
32707033
Intra AURKC Q9UQB9 INCENP Homo sapiens Q9NQS7
Anti Tag CoIP
27332895
Intra AURKC Q9UQB9 INCENP Homo sapiens Q9NQS7
Anti Tag CoIP
33961781
Intra AURKC Q9UQB9 INCENP Homo sapiens Q9NQS7
IF
27332895
Intra AURKC Q9UQB9 INCENP Homo sapiens Q9NQS7
Anti Bait CoIP
27332895
Intra AURKC Q9UQB9 INCENP Homo sapiens Q9NQS7
Pull Down
27332895
Intra AURKC Q9UQB9 INCENP Homo sapiens Q9NQS7
Protein Kinase Assay
27332895
Intra AURKC Q9UQB9 BIRC7 Homo sapiens Q96CA5
Y2H Prey Pooling
32296183
Intra AURKC Q9UQB9 BIRC7 Homo sapiens Q96CA5
Y2H Array
32296183
Intra AURKC Q9UQB9 BIRC5 Homo sapiens O15392
Pull Down
27332895
Intra AURKC Q9UQB9 BIRC5 Homo sapiens O15392
Anti Bait CoIP
27332895
Intra AURKC Q9UQB9 BIRC5 Homo sapiens O15392
IF
27332895
Intra AURKC Q9UQB9 BIRC5 Homo sapiens O15392
Anti Tag CoIP
27332895
Intra AURKC Q9UQB9 OTX2 Homo sapiens P32243-2
Y2H Prey Pooling
32296183
Intra AURKC Q9UQB9 OTX2 Homo sapiens P32243-2
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Male Infertility With Spermatogenesis Disorder
Spermatogenic Failure

Azoospermia

Spgf

Spermatogenic Failure, Susceptibility To

Absent Sperm

Aspermatogenesis

Infertility Due To Azoospermia

Hypospermatogenesis

Azoospermatism
Nystagmus 3, Congenital, Autosomal Dominant

NYS3

Congenital Nystagmus 3

Autosomal Dominant Congenital Nystagmus 3
Vas Deferens, Congenital Bilateral Aplasia Of

Congenital Bilateral Absence Of Vas Deferens

CBAVD

Cavd

Congenital Bilateral Aplasia Of Vas Deferens

Congenital Bilateral Absence Of The Vas Deferens

Congenital Bilateral Agenesis Of Vas Deferens

Absence Of Vas Deferens

Absent Vasa

Congenital Absence Of Vas Deferens

Congenital Aplasia Of Vas Deferens

Absent Vas Deferens

Vas Deferens, Congenital Bilateral Absence
Infertility
Spermatogenic Failure 9

Male Infertility Due To Globozoospermia

SPGF9

Male Infertility Due To Round-Headed Spermatozoa

Globozoospermia, Complete

Globozoospermia, Total

Globozoospermia

Globozoospermia Syndrome

Round-Headed Sperm Syndrome

Globozoospermia Complete

Globozoospermia Total
Prostate Carcinoma In Situ

Carcinoma In Situ Of Prostate

Grade Iii Pin

Pin Iii
Spermatogenic Failure 5

Male Infertility With Large-Headed, Multiflagellar, Polyploid Spermatozoa

Infertility Associated With Multi-Tailed Spermatozoa And Excessive Dna

SPGF5

Macrocephalic Sperm Head Syndrome

Male Infertility Due To Macrozoospermia

Infertility Associated With Multitailed Spermatozoa And Excessive Dna

Macrozoospermia

Male Infertility Due To Large-Headed Multiflagellar Polyploid Spermatozoa

Infertility Associated With Multi-Tailed Spermatozoa And Excessive Deoxyribonucleic Acid

Large-Headed Multiflagellar Polyploid Spermatozoa

Male Infertility With Large-Headed Multiflagellar Polyploid Spermatozoa
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (7)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-120279A CFI-400437 Inhibitor / 否
HY-123610 BRD-7880 Inhibitor / 否
HY-160691 GW814408X / 否
HY-RS01273 AURKC Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS01274 Aurkc Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS01275 AURKC Rat Pre-designed siRNA Set A Pre-designed Sets / 否
HY-119948 AKCI Modulator / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta AURKC VGNC VGNC:70051
Mus musculus AURKC MGD MGI:1321119
Felis catus AURKC VGNC VGNC:60045
Rattus norvegicus AURKC RGD RGD:1309573
Canis familiaris AURKC VGNC VGNC:38313
Others AURKC NCBI
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