POLRMT - RNA polymerase mitochondrial Gene

中文名称：RNA 聚合酶线粒体

种属: Homo sapiens

同用名: APOLMT; MTRNAP; MTRPOL; COXPD55; h-mtRPOL

基因 ID: 5442 | 基因类型: protein coding

关于 POLRMT

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:617,221-633,537 (from NCBI)

This gene has 8 transcripts (splice variants), 198 orthologues and is associated with 1 phenotype. Broad expression in testis (RPKM 15.0), kidney (RPKM 8.1) and 25 other tissues.

功能概要

该基因编码线粒体 DNA 指导的 RNA 聚合酶。该基因产物负责线粒体基因表达以及提供 RNA 引物以启动线粒体基因组的复制。虽然这种多肽与三种核 DNA 指导的 RNA 聚合酶具有相同的功能，但它与噬菌体的 RNA 聚合酶和低等真核生物的线粒体聚合酶的关系更为密切。[RefSeq 提供，2008 年 7 月]

This gene encodes a mitochondrial DNA-directed RNA polymerase. The gene product is responsible for mitochondrial gene expression as well as for providing RNA primers for initiation of replication of the mitochondrial genome. Although this polypeptide has the same function as the three nuclear DNA-directed RNA polymerases, it is more closely related to RNA polymerases of phage and mitochondrial polymerases of lower eukaryotes. [provided by RefSeq, Jul 2008]

POLRMT 基因产物(21)

mRNA	Protein	Name
NM_001407805.1	NP_001394734.1	DNA-directed RNA polymerase, mitochondrial isoform 1 precursor
NM_001407806.1	NP_001394735.1	DNA-directed RNA polymerase, mitochondrial isoform 2 precursor
NM_001407807.1	NP_001394736.1	DNA-directed RNA polymerase, mitochondrial isoform 3 precursor
NM_001407808.1	NP_001394737.1	DNA-directed RNA polymerase, mitochondrial isoform 4 precursor
NM_001407809.1	NP_001394738.1	DNA-directed RNA polymerase, mitochondrial isoform 6 precursor
NM_001407810.1	NP_001394739.1	DNA-directed RNA polymerase, mitochondrial isoform 7 precursor
NM_001407811.1	NP_001394740.1	DNA-directed RNA polymerase, mitochondrial isoform 8 precursor
NM_001407812.1	NP_001394741.1	DNA-directed RNA polymerase, mitochondrial isoform 9 precursor
NM_001407813.1	NP_001394742.1	DNA-directed RNA polymerase, mitochondrial isoform 10 precursor
NM_001407814.1	NP_001394743.1	DNA-directed RNA polymerase, mitochondrial isoform 11 precursor
NM_001407815.1	NP_001394744.1	DNA-directed RNA polymerase, mitochondrial isoform 12 precursor
NM_001407816.1	NP_001394745.1	DNA-directed RNA polymerase, mitochondrial isoform 13 precursor
NM_001407829.1	NP_001394758.1	DNA-directed RNA polymerase, mitochondrial isoform 14 precursor
NM_001407830.1	NP_001394759.1	DNA-directed RNA polymerase, mitochondrial isoform 15 precursor
NM_001407831.1	NP_001394760.1	DNA-directed RNA polymerase, mitochondrial isoform 16
NM_001407832.1	NP_001394761.1	DNA-directed RNA polymerase, mitochondrial isoform 17 precursor
NM_001407833.1	NP_001394762.1	DNA-directed RNA polymerase, mitochondrial isoform 18
NM_001407834.1	NP_001394763.1	DNA-directed RNA polymerase, mitochondrial isoform 19
NM_001407835.1	NP_001394764.1	DNA-directed RNA polymerase, mitochondrial isoform 20
NM_001407836.1	NP_001394765.1	DNA-directed RNA polymerase, mitochondrial isoform 21
NM_005035.4	NP_005026.3	DNA-directed RNA polymerase, mitochondrial isoform 5 precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables 3'-5'-RNA exonuclease activity	IDA IDA: 通过直接分析推断	35449456	GOA
enables DNA primase activity	IDA IDA: 通过直接分析推断	18685103	GOA
enables DNA-directed 5'-3' RNA polymerase activity	IDA IDA: 通过直接分析推断	21278163	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	17337445	GOA
enables sequence-specific DNA binding	IDA IDA: 通过直接分析推断	29445193	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in mitochondrial transcription	IDA IDA: 通过直接分析推断	21278163	GOA
involved in transcription initiation at mitochondrial promoter	IDA IDA: 通过直接分析推断	29149603	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in mitochondrial matrix	IDA IDA: 通过直接分析推断	29445193	GOA
located in mitochondrial nucleoid	IDA IDA: 通过直接分析推断	18063578	GOA
located in mitochondrion	IDA IDA: 通过直接分析推断	17337445	GOA
part of protein-containing complex	IDA IDA: 通过直接分析推断	23283301	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

POLRMT 蛋白结构

RPOL_N

RNA_pol

0
200
400
600
800
1000
1230 a.a.

蛋白主名

其他名称

DNA-directed RNA polymerase, mitochondrial

polymerase (RNA) mitochondrial (DNA directed)

POLRMT 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	POLRMT	O00411	MRPL12	Homo sapiens	P52815	Anti Tag CoIP	22003127
种属内	POLRMT	O00411	TEFM	Homo sapiens	Q96QE5	Pull Down	21278163

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Combined Oxidative Phosphorylation Deficiency 55

COXPD55

Cardiomyopathy, Infantile Hypertrophic

Infantile Hypertrophic Cardiomyopathy

CMHI

Mitochondrial Dna Depletion Syndrome 4a

Alpers Syndrome	Alpers-Huttenlocher Syndrome
Alpers Progressive Infantile Poliodystrophy	Alpers Diffuse Degeneration Of Cerebral Gray Matter With Hepatic Cirrhosis
Alpers Disease	Progressive Sclerosing Poliodystrophy
Pndc	Diffuse Cerebral Sclerosis Of Schilder
MTDPS4A	Neuronal Degeneration Of Childhood With Liver Disease, Progressive
Alper'S Syndrome	Alpers' Disease Or Gray-Matter Degeneration
Diffuse Cerebral Degeneration In Infancy	Infantile Poliodystrophy
Poliodystrophia Cerebri Progressiva	Progressive Cerebral Poliodystrophy
Alpers' Disease	Alpers Progressive Sclerosing Poliodystrophy
Progressive Neuronal Degeneration Of Childhood With Liver Disease	Ahs
Mitochondrial Dna Depletion Syndrome 4a Alpers Type	Neuronal Degeneration Of Childhood With Liver Disease Progressive

Mitochondrial Dna Depletion Syndrome

Mtdna Depletion Syndrome

Mitochondrial Myopathy

Mitochondrial Myopathies	Mitochondrial Cytopathy
Myopathies In Mitochondrial Disorders

Leber Hereditary Optic Neuropathy, Modifier Of

Leber Optic Atrophy	Leber Hereditary Optic Neuropathy
LHON	Leber'S Hereditary Optic Neuropathy
Leber Optic Atrophy, Susceptibility To	Leber'S Optic Atrophy
LOAM	Loas
Leber'S Disease	Leber'S Optic Neuropathy
Optic Atrophy, Hereditary, Leber	Lhon, Modifier Of
Optic Atrophy, Leber Type	Hereditary Optic Neuroretinopathy
Leber Hereditary Optic Atrophy	Loa
Optic Atrophy Leber Type	Leber Hereditary Optic Neuropathy, Modifier
Leber Hereditary Optic Neuropathy Susceptibility	Modifier Of Leber Hereditary Optic Neuropathy
Lebers Hereditary Optic Neuropathy	Leber Congenital Amaurosis

Leigh Syndrome

Leigh Disease	Infantile Subacute Necrotizing Encephalopathy
Leigh Syndrome Due To Mitochondrial Complex Iv Deficiency	LS
Sne	Leigh'S Disease
Leigh Syndrome Due To Mitochondrial Complex I Deficiency	Necrotizing Encephalopathy, Infantile Subacute, Of Leigh
Subacute Necrotizing Encephalomyelopathy	Necrotizing Encephalopathy Infantile Subacute Of Leigh
Leigh Syndrome Due To Mitochondrial Complex Iii Deficiency	Infantile Necrotizing Encephalomyelopathy
Juvenile Subacute Necrotizing Encephalomyelopathy	Leigh'S Necrotizing Encephalopathy
Subacute Necrotizing Encephalopathy	Juvenile Subacute Necrotizing Encephalopathy
Leigh Syndrome Due To Mitochondrial Complex Ii Deficiency	Leigh Syndrome Due To Mitochondrial Complex V Deficiency
Encephalopathy, Subacute Necrotizing, Infantile	Encephalopathy, Subacute Necrotizing, Juvenile
Maternally Inherited Leigh Syndrome	Subacute Necrotising Encephalomyelopathy
Subacute Necrotising Encephalopathy

Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, And Stroke-Like Episodes

Melas Syndrome	MELAS
Mitochondrial Encephalomyopathy Lactic Acidosis And Stroke-Like Episodes	Mitochondrial Myopathy, Lactic Acidosis, Stroke-Like Episode
Mitochondrial Encephalomyopathy, Lactic Acidosis, And Stroke-Like Episodes	Myopathy, Mitochondrial-Encephalopathy-Lactic Acidosis-Stroke
Mitochondrial Encephalomyopathy, Lactic Acidosis And Stroke-Like Episodes	Mitochondrial Encephalopathy, Lactic Acidosis, And Stroke-Like Episodes
Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis And Stroke-Like Episodes	Mitochondrial Encephalomyopathy With Lactic Acidosis And Stroke-Like Episodes Syndrome
Myopathy, Mitochondrial, Encephalopathy, Lactic Acidosis, And Stroke-Like Episodes

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-134539	IMT1	Inhibitor	98.13%	否
HY-137067	IMT1B	Inhibitor	99.36%	否
HY-163892	POLRMT-IN-1	Inhibitor	/	否
HY-RS10863	POLRMT Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	POLRMT	VGNC	VGNC:108252
Rattus norvegicus	POLRMT	RGD	RGD:1304599
Mus musculus	POLRMT	MGD	MGI:1915843
Felis catus	POLRMT	VGNC	VGNC:68956
Bos taurus	POLRMT	VGNC	VGNC:33154

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

POLRMT - RNA polymerase mitochondrial Gene

关于 POLRMT

功能概要

POLRMT 基因产物(21)

POLRMT 蛋白结构

POLRMT 蛋白互作信息

关联疾病

直系同源

热门区域

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POLRMT - RNA polymerase mitochondrial Gene

关于 POLRMT

功能概要

POLRMT 基因产物(21)

POLRMT 蛋白结构

POLRMT 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z