PPP1R16A - protein phosphatase 1 regulatory subunit 16A Gene

中文名称：蛋白磷酸酶 1 调节亚基 16A

种属: Homo sapiens

同用名: MYPT3

关于 PPP1R16A

功能概要

肌球蛋白轻链激酶和磷酸酶 (MLCP) 复合物控制调节性肌球蛋白轻链的磷酸化状态，这对肌肉和细胞内运动至关重要。 MLCP 通常包含催化蛋白磷酸酶 1 (PP1c) 亚基、肌球蛋白磷酸酶靶向 (MYPT) 亚基和另一个较小的亚基。该基因编码的蛋白质代表一个 MYPT 亚基，它负责将 PP1c 导向其预期目标。然而，虽然其他 MYPT 成员的磷酸化导致 PP1c 失活，但蛋白激酶 A 对编码蛋白的磷酸化导致 PP1c 激活。[RefSeq 提供，2020 年 1 月]

Myosin light chain kinase and Phosphatase (MLCP) complexes control the phosphorylation states of regulatory Myosin light chains, which is crucial for muscle and intracellular movement. MLCPs typically contain a catalytic protein Phosphatase 1 (PP1c) subunit, a myosin Phosphatase targeting (MYPT) subunit, and another smaller subunit. The protein encoded by this gene represents an MYPT subunit, which is responsible for directing PP1c to its intended targets. However, while the phosphorylation of Other MYPT members results in PP1c inactivation, phosphorylation of the encoded protein by protein kinase A results in PP1c activation. [provided by RefSeq, Jan 2020]