2. Gene
  3. MGA - MAX dimerization protein MGA Gene

MGA - MAX dimerization protein MGA Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：MAX 二聚化蛋白 MGA

种属: Homo sapiens

同用名: MAD5; MXD5

基因 ID: 23269 | 基因类型: protein coding

关于 MGA

Cytogenetic location: 15q15.1 Genomic coordinates (GRCh38): 15:41,621,224-41,769,940 (from NCBI)

This gene has 16 transcripts (splice variants), 293 orthologues and 16 paralogues. Ubiquitous expression in ovary (RPKM 5.9), testis (RPKM 5.5) and 25 other tissues.

功能概要

预测可实现 DNA 结合转录激活因子活性、RNA 聚合酶 II 特异性和 RNA 聚合酶 II 顺式调节区序列特异性 DNA 结合活性。预计参与细胞命运规范和 RNA 聚合酶 II 对转录的正调控。预计在白血病抑制因子的细胞反应上游或细胞反应中起作用。 MLL1 复合体的一部分。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in cell fate specification and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within cellular response to Leukemia Inhibitory Factor. Part of MLL1 complex. [provided by Alliance of Genome Resources, Apr 2022]

MGA 基因产物(9)

mRNA Protein Name
NM_001080541.3 NP_001074010.2 MAX gene-associated protein isoform 2
NM_001164273.2 NP_001157745.1 MAX gene-associated protein isoform 1
NM_001400225.1 NP_001387154.1 MAX gene-associated protein isoform 3
NM_001400242.1 NP_001387171.1 MAX gene-associated protein isoform 4
NM_001400243.1 NP_001387172.1 MAX gene-associated protein isoform 5
NM_001400244.1 NP_001387173.1 MAX gene-associated protein isoform 5
NM_001400245.1 NP_001387174.1 MAX gene-associated protein isoform 5
NM_001400246.1 NP_001387175.1 MAX gene-associated protein isoform 5
NM_001400247.1 NP_001387176.1 MAX gene-associated protein isoform 5
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
20936779 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of MLL1 complex IDA
IDA: 通过直接分析推断
15960975 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MGA 蛋白结构

T-box

T-box: T-box (77 - 261)

HLH

HLH: Helix-loop-helix DNA-binding domain (2425 - 2474)

  • 0
  • 500
  • 1000
  • 1500
  • 2000
  • 2500
  • 3065 a.a.
蛋白主名 其他名称

MAX gene-associated protein

MAX dimerization protein 5

MGA 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra MGA Q8IWI9 MAX Homo sapiens P61244
Y2H Pooling
20936779
Intra MGA Q8IWI9 CBX3 Homo sapiens Q13185
Y2H Pooling
20936779
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Spindle Cell Sarcoma

Sarcoma

Sarcoma Spindle Cell

Sarcoma, Spindle Cell

Sarcoma - Category
Blue Toe Syndrome
Plasma Cell Neoplasm

Plasma Cell Dyscrasia

Paraproteinemias

Plasma Cell Tumour

Plasmacytic Tumor

Multiple Myeloma

Plasmacytoma

Plasma Cell Tumours

Plasma Cells Dyscrasia
Psoriasis 5

PSORS5

Psoriasis Susceptibility 5

Psoriasis 5, Susceptibility To
Myeloma, Multiple

Multiple Myeloma

Plasma Cell Myeloma

Kahler Disease

Myelomatosis

Medullary Plasmacytoma

Multiple Myeloma, Resistance To

Myeloma

Plasma Cell Dyscrasia

Kahler'S Disease

Multiple Myeloma, Susceptibility To

Myeloma - Multiple

Kahler-Bozzolo Disease

Plasma Cell Myelomas

MM

Plasma Cell Neoplasm

Primary Systemic Amyloidosis

Primary Amyloidosis

Immunoglobulin Deposition Disease

Plasmacytic Myeloma

Multiple Myelomata

Multiple Myeloma Nos

Multiple Myeloma Without Mention Of Remission

Monostotic Plasma Cell Myeloma

Mm - [Multiple Myeloma]
Psoriasis 3

PSORS3

Psoriasis Susceptibility 3

Psoriasis 3, Susceptibility To
Cholesterol Embolism

Atheroembolism

Trash Foot

Cholesterol Crystal Embolism

Purple Toe Syndrome

Warfarin Blue Toe Syndrome

Embolism, Cholesterol

Cholesterol Embolus Syndrome
Cataract 37

CTRCT37

Cca5

Cataract, Congenital, Cerulean Type, 5

Cataract 37, Autosomal Dominant

Congenital Cataract Cerulean Type 5
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Approval
抗体抑制剂 (1)
目录号 产品名 作用方式
纯度 是否罕见病
HY-P99222 Teplizumab ≥99.0% 否
Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-111614 Melengestrol acetate Activator 99.76% 否
HY-RS08395 MGA Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus MGA VGNC VGNC:31445
Canis familiaris MGA VGNC VGNC:43210
Felis catus MGA VGNC VGNC:63486
Rattus norvegicus MGA RGD RGD:1561597
Mus musculus MGA MGD MGI:1352483
Macaca mulatta MGA VGNC VGNC:84390
Others MGA NCBI
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z