PRR14 - proline rich 14 Gene

中文名称：富脯氨酸 14

种属: Homo sapiens

关于 PRR14

功能概要

由该基因编码的蛋白质通过结合异染色质蛋白 1 (HP1) 和核层将异染色质系在核层支架上。系链在有丝分裂期间断裂，并在有丝分裂后迅速重组，编码的蛋白质首先结合 HP1，然后附着在核层上。这种蛋白质也被证明可以促进 MyoD 活性和骨骼肌生成。已发现该基因编码相同蛋白质的两个转录变体。[RefSeq 提供，2016 年 2 月]

The protein encoded by this gene tethers heterochromatin to the nuclear laminar scaffold by binding heterochromatin protein 1 (HP1) and the nuclear lamina. The tether is broken during mitosis and reforms quickly after mitosis, with the encoded protein first binding HP1 and then attaching to the nuclear lamina. This protein also has been shown to promote MyoD activity and skeletal myogenesis. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Feb 2016]