2. Gene
  3. TRIM28 - tripartite motif containing 28 Gene

TRIM28 - tripartite motif containing 28 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：含三方基序 28

种属: Homo sapiens

同用名: KAP1; TF1B; RNF96; TIF1B; PPP1R157; TIF1beta

基因 ID: 10155 | 基因类型: protein coding

关于 TRIM28

Cytogenetic location: 19q13.43 Genomic coordinates (GRCh38): 19:58,544,064-58,550,715 (from NCBI)

This gene has 15 transcripts (splice variants), 143 orthologues, 80 paralogues and is associated with 1 phenotype. Ubiquitous expression in ovary (RPKM 89.1), testis (RPKM 80.5) and 25 other tissues.

功能概要

由该基因编码的蛋白质通过与许多转录因子中发现的 Kruppel 相关框抑制域相互作用来介导转录控制。该蛋白质定位于细胞核，被认为与特定的染色质区域相关。该蛋白质是三联基序家族的成员。这个三联基序包括三个锌结合域、一个 RING、一个 B-box 类型 1 和一个 B-box 类型 2，以及一个卷曲螺旋区域。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene mediates transcriptional control by interaction with the Kruppel-associated box repression domain found in many transcription factors. The protein localizes to the nucleus and is thought to associate with specific chromatin regions. The protein is a member of the tripartite motif family. This tripartite motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. [provided by RefSeq, Jul 2008]

TRIM28 基因产物(1)

mRNA Protein Name
NM_005762.3 NP_005753.1 transcription intermediary factor 1-beta
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA binding IDA
IDA: 通过直接分析推断
9016654 GOA
enables Krueppel-associated box domain binding IDA
IDA: 通过直接分析推断
17512541 GOA
enables SUMO transferase activity EXP
EXP: 通过实验结果推断
17298944 GOA
enables chromatin binding IDA
IDA: 通过直接分析推断
27029610 GOA
enables chromo shadow domain binding IPI
IPI: 通过物理相互作用推断
15882967 GOA
enables promoter-specific chromatin binding IDA
IDA: 通过直接分析推断
24623306 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
9016654 GOA
enables transcription corepressor activity IDA
IDA: 通过直接分析推断
8769649 GOA
enables ubiquitin protein ligase activity IMP
IMP: 通过突变表型推断
36354136 GOA
enables ubiquitin protein ligase binding IDA
IDA: 通过直接分析推断
18082607 GOA
enables ubiquitin-protein transferase activity IDA
IDA: 通过直接分析推断
18082607 GOA
enables zinc ion binding IDA
IDA: 通过直接分析推断
10653693 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in DNA repair IDA
IDA: 通过直接分析推断
17178852 GOA
involved in innate immune response IDA
IDA: 通过直接分析推断
18248090 GOA
involved in negative regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
9016654 GOA
involved in positive regulation of DNA methylation-dependent heterochromatin formation IMP
IMP: 通过突变表型推断
24623306 GOA
involved in positive regulation of DNA repair IDA
IDA: 通过直接分析推断
17178852 GOA
involved in positive regulation of protein import into nucleus IDA
IDA: 通过直接分析推断
23665872 GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process IMP
IMP: 通过突变表型推断
36354136 GOA
involved in protein sumoylation IDA
IDA: 通过直接分析推断
18082607 GOA
involved in suppression of viral release by host IDA
IDA: 通过直接分析推断
18248090 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
8769649 GOA
part of protein-containing complex IDA
IDA: 通过直接分析推断
17512541 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TRIM28 蛋白结构

zf-RING_5

zf-RING_5: zinc-RING finger domain (64 - 122)

zf-B_box

zf-B_box: B-box zinc finger (150 - 194)

zf-B_box

zf-B_box: B-box zinc finger (207 - 243)

PHD

PHD: PHD-finger (627 - 670)

  • 0
  • 200
  • 400
  • 600
  • 835 a.a.
蛋白主名 其他名称

transcription intermediary factor 1-beta

E3 SUMO-protein ligase TRIM28

TRIM28 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra TRIM28 Q13263 MAGEA6 Homo sapiens P43360
Pull Down
20864041
Intra TRIM28 Q13263 ZNF10 Homo sapiens P21506
Anti Tag CoIP
35271311
Intra TRIM28 Q13263 ZFP90 Homo sapiens Q8TF47-3
Anti Tag CoIP
23543754
Intra TRIM28 Q13263 ZNF84 Homo sapiens P51523
Anti Tag CoIP
33961781
Intra TRIM28 Q13263 NCOR1 Homo sapiens O75376
Chromatography
11013263
Intra TRIM28 Q13263 NCOR1 Homo sapiens O75376
IF
11013263
Intra TRIM28 Q13263 ZNF350 Homo sapiens Q9GZX5
Anti Tag CoIP
22975076
Intra TRIM28 Q13263 ZNF649 Homo sapiens Q9BS31
Anti Tag CoIP
33961781
Intra TRIM28 Q13263 ZNF649 Homo sapiens Q9BS31
Anti Tag CoIP
35271311
Intra TRIM28 Q13263 CHD3 Homo sapiens Q12873
Y2H Pooling
16169070
Intra TRIM28 Q13263 CHD3 Homo sapiens Q12873
Anti Tag CoIP
21642969
Intra TRIM28 Q13263 MAGEA2 Homo sapiens P43356
Pull Down
20864041
Intra TRIM28 Q13263 MAGEA2 Homo sapiens P43356
TAP
20864041
Intra TRIM28 Q13263 MAGEA2 Homo sapiens P43356
Ubiquitinase Assay
20864041
Intra TRIM28 Q13263 MAGEA2 Homo sapiens P43356
Anti Tag CoIP
20864041
Intra TRIM28 Q13263 MAGEA3 Homo sapiens P43357
Pull Down
20864041
Intra TRIM28 Q13263 MAGEC2 Homo sapiens Q9UBF1
Anti Bait CoIP
20864041
Intra TRIM28 Q13263 MAGEC2 Homo sapiens Q9UBF1
GMS
20864041
Intra TRIM28 Q13263 MAGEC2 Homo sapiens Q9UBF1
Anti Bait CoIP
21277283
Intra TRIM28 Q13263 MAGEC2 Homo sapiens Q9UBF1
IF
20864041
Intra TRIM28 Q13263 MAGEC2 Homo sapiens Q9UBF1
Pull Down
20864041
Intra TRIM28 Q13263 MAGEC2 Homo sapiens Q9UBF1
Ubiquitinase Assay
20864041
Intra TRIM28 Q13263 MAGEC2 Homo sapiens Q9UBF1
Anti Tag CoIP
20864041
Intra TRIM28 Q13263 ZNF136 Homo sapiens P52737
Anti Tag CoIP
33961781
Intra TRIM28 Q13263 ZNF136 Homo sapiens P52737
Anti Tag CoIP
31403225
Cross TRIM28 Q13263 Cbx1 Mus musculus P83917
Pull Down
10330177
Intra TRIM28 Q13263 CBX3 Homo sapiens Q13185
Pull Down
10330177
Intra TRIM28 Q13263 CBX3 Homo sapiens Q13185
Anti Tag CoIP
33961781
Intra TRIM28 Q13263 CBX3 Homo sapiens Q13185
Anti Tag CoIP
35271311
Intra TRIM28 Q13263 CBX5 Homo sapiens P45973
Pull Down
10330177
Intra TRIM28 Q13263 CBX5 Homo sapiens P45973
Anti Tag CoIP
33961781
Intra TRIM28 Q13263 CBX5 Homo sapiens P45973
Y2H
20562864
Intra TRIM28 Q13263 CBX5 Homo sapiens P45973
Anti Tag CoIP
35271311
Intra TRIM28 Q13263 ZNF765 Homo sapiens Q7L2R6
Anti Tag CoIP
33961781
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Wilms Tumor 1

Nephroblastoma

Wilms Tumor

WT1

Wilms' Tumor

Bilateral Wilms Tumor

Wilms Tumor, Type 1

Wilms Tumor, Somatic

Adult Nephroblastoma

Wt1 Disorder

Renal Embryonic Tumor

Adult Kidney Wilms Tumor

Childhood Kidney Wilms Tumor

Nonanaplastic Kidney Wilms Tumor
Wilms Tumor 5

Wilms Tumor

WT5

Wilms Tumor Susceptibility-5

Wilms Tumor And Radial Bilateral Aplasia

Nephroblastoma

Wilms' Tumor

Wilms Tumor, Susceptibility To

Wtsl

Bilateral Radial Aplasia With Wilms Tumor

Embryonal Adenosarcoma

Embryonal Nephroma

Kidney Wilms Tumor

Kidney, Adenomyosarcoma, Embryonal

Kidney, Carcinosarcoma, Embryonal

Kidney, Embryoma

Kidney, Embryonal Mixed Tumor

Nephroma

Renal Adenosarcoma

Renal Cancer, Wilms

Renal Wilms Tumor

Tumor, Wilms

Hereditary Susceptibility To Wilms Tumor 5
Hyperoxaluria, Primary, Type I

Primary Hyperoxaluria Type 1

HP1

Glycolic Aciduria

Alanine-Glyoxylate Aminotransferase Deficiency

Hepatic Agt Deficiency

Oxalosis I

Primary Hyperoxaluria, Type I

Serine:Pyruvate Aminotransferase Deficiency

Hyperoxaluria, Primary, Type 1

Peroxisomal Alanine-Glyoxylate Aminotransferase Deficiency

Peroxisomal Alanine Glyoxylate Aminotransferase Deficiency

Serine Pyruvate Aminotransferase Deficiency

Peroxisomal Alanine:Glyoxylate Aminotransferase Deficiency

Oxalosis 1

Hyperoxaluria Primary 1

Hyperoxaluria Primary Type I

Ph1

Primary Hyperoxaluria Type I

Oxalosis Type 1

2-Oxoglutarate Glyoxylate Carboligase Deficiency
Primary Hyperoxaluria

Hyperoxaluria

Hyperoxaluria, Primary

Oxalosis

Primary Oxalosis

Congenital Oxaluria

D-Glycerate Dehydrogenase Deficiency

Glyceric Aciduria

Glycolic Aciduria

Hepatic Agt Deficiency

Oxaluria, Primary

Peroxisomal Alanine:Glyoxylate Aminotransferase Deficiency

Primary Oxaluria

Hyperoxaluria Primary

Primary Hyperoxaluria Type 2

Primary Hyperoxaluria, Type I
Hereditary Wilms' Tumor

Hereditary Wilms Tumor

Hereditary Wilms Tumour

Hereditary Wilms' Tumour

Wt1
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon
Burkitt Lymphoma

Burkitt'S Lymphoma

BL

Burkitt Lymphoma, Somatic

Burkitt Lymphoma/Leukaemia

Burkitt'S Tumor

Burkitt'S Tumor Or Lymphoma

Malignant Lymphoma, Burkitt'S Type

Small Non-Cleaved Cell Lymphoma, Burkitt'S Type

Small Non-Cleaved Cell Lymphoma

Burkitt Tumor

Burkitts Lymphoma

Lymphoma, Small Noncleaved-Cell

Burkitt Tumour

Diffuse Small Noncleaved Malignant Burkitt Lymphoma

Malignant Burkitt Lymphoma

“Burkitt-Like” Lymphoma

Undifferentiated Burkitt Lymphoma

Small Noncleaved Cell Burkitt Lymphoma
Transient Neonatal Diabetes Mellitus

Diabetes Mellitus, Transient Neonatal

Tndm

Chromosome 6-Associated Transient Diabetes Mellitus

Dmtn

Diabetes Mellitus, 6q24-Related Transient Neonatal

Tndm1

Neonatal Diabetes Mellitus, Transient

Tndm -[Transient Neonatal Diabetes Mellitus]
Autism Spectrum Disorder

Asd

Autism Spectrum Disorders

Autistic Continuum

Pervasive Developmental Disorder

Pervasive Development Disorder

Autistic Behavior

Autistic Disorder

Autistic

Autistic Disorder Of Childhood Onset

Infantile Autism

Childhood Autism

Kanner Syndrome

Pervasive Developmental Delay Nos

Pervasive Developmental Disorder, Not Otherwise Specified
Autism

Autistic Disorder

Autism Susceptibility 1

Childhood Autism

Autistic Disorder Of Childhood Onset

Infantile Autism

Kanner'S Syndrome

Autistic
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS15033 TRIM28 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus TRIM28 RGD RGD:620289
Macaca mulatta TRIM28 VGNC VGNC:79033
Bos taurus TRIM28 VGNC VGNC:36324
Felis catus TRIM28 VGNC VGNC:82332
Mus musculus TRIM28 MGD MGI:109274
Canis familiaris TRIM28 VGNC VGNC:47811
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