MAGEC2 - MAGE family member C2 Gene

中文名称：MAGE 家族成员 C2

种属: Homo sapiens

同用名: CT10; HCA587; MAGEE1

基因 ID: 51438 | 基因类型: protein coding

关于 MAGEC2

Cytogenetic location: Xq27.2 Genomic coordinates (GRCh38): X:142,202,342-142,205,290 (from NCBI)

This gene has 1 transcript (splice variant), 463 orthologues and 37 paralogues. Restricted expression toward testis (RPKM 15.6).

功能概要

该基因是 MAGEC 基因家族的成员。它在除睾丸外的正常组织中不表达，并在各种组织学类型的肿瘤中表达。该基因和其他 MAGEC 基因聚集在染色体 Xq26-q27 上。[RefSeq 提供，2009 年 10 月]

This gene is a member of the MAGEC gene family. It is not expressed in normal tissues, except for testis, and is expressed in tumors of various histological types. This gene and the other MAGEC genes are clustered on chromosome Xq26-q27. [provided by RefSeq, Oct 2009]

MAGEC2 基因产物(1)

mRNA	Protein	Name
NM_016249.4	NP_057333.1	melanoma-associated antigen C2

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	20864041	GOA
enables ubiquitin protein ligase binding	IDA IDA: 通过直接分析推断	20864041	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in positive regulation of ubiquitin-protein transferase activity	IMP IMP: 通过突变表型推断	20864041	GOA
involved in protein catabolic process	IMP IMP: 通过突变表型推断	20864041	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MAGEC2 蛋白结构

MAGE_N

MAGE

0
100
200
300
373 a.a.

蛋白主名

其他名称

melanoma-associated antigen C2

MAGE-C2 antigen

MAGEC2 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	MAGEC2	Q9UBF1	P4HA3	Homo sapiens	Q7Z4N8	Validated Y2H	25416956
Intra	MAGEC2	Q9UBF1	P4HA3	Homo sapiens	Q7Z4N8	Y2H Array	31515488
Intra	MAGEC2	Q9UBF1	SSX1	Homo sapiens	Q16384	Y2H Prey Pooling	25416956
Intra	MAGEC2	Q9UBF1	SSX1	Homo sapiens	Q16384	Y2H Array	25416956
Intra	MAGEC2	Q9UBF1	PBX3	Homo sapiens	Q5JS98	Y2H Prey Pooling	25416956
Intra	MAGEC2	Q9UBF1	PBX3	Homo sapiens	Q5JS98	Validated Y2H	25416956
Intra	MAGEC2	Q9UBF1	PBX3	Homo sapiens	Q5JS98	Y2H Array	25416956
Intra	MAGEC2	Q9UBF1	YARS1	Homo sapiens	P54577	Validated Y2H	32814053
Intra	MAGEC2	Q9UBF1	YARS1	Homo sapiens	P54577	Y2H Array	32814053
Intra	MAGEC2	Q9UBF1	YARS1	Homo sapiens	P54577	Y2H Pooling	32814053
Intra	MAGEC2	Q9UBF1	GLE1	Homo sapiens	Q53GS7	Validated Y2H	32814053
Intra	MAGEC2	Q9UBF1	GLE1	Homo sapiens	Q53GS7	Y2H Array	32814053
Intra	MAGEC2	Q9UBF1	GLE1	Homo sapiens	Q53GS7	Y2H Pooling	32814053
Intra	MAGEC2	Q9UBF1	UBE2H	Homo sapiens	P62256	Pull Down	20864041
Intra	MAGEC2	Q9UBF1	SSX2	Homo sapiens	Q16385	Y2H Array	25416956
Intra	MAGEC2	Q9UBF1	SSX2	Homo sapiens	Q16385	Y2H Prey Pooling	25416956
Intra	MAGEC2	Q9UBF1	SSX2	Homo sapiens	Q16385	Validated Y2H	25416956
Intra	MAGEC2	Q9UBF1	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	MAGEC2	Q9UBF1	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	MAGEC2	Q9UBF1	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	MAGEC2	Q9UBF1	TRIM28	Homo sapiens	Q13263	Pull Down	20864041
Intra	MAGEC2	Q9UBF1	TRIM28	Homo sapiens	Q13263	Y2H	21277283
Intra	MAGEC2	Q9UBF1	TRIM28	Homo sapiens	Q13263	TAP	20864041

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Melanoma

Malignant Melanoma	Cutaneous Melanoma
Naevocarcinoma	Malignant Melanomas

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

Malignant Anus Melanoma

Anal Melanoma

Malignant Melanoma Of Anus

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS07974	MAGEC2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	MAGEC2	RGD	RGD:1563272
Mus musculus	MAGEC2	MGD	MGI:1921687

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