SSX1 - SSX family member 1 Gene

中文名称：SSX 家族成员 1

种属: Homo sapiens

同用名: SSRC; CT5.1

基因 ID: 6756 | 基因类型: protein coding

关于 SSX1

Cytogenetic location: Xp11.23 Genomic coordinates (GRCh38): X:48,255,392-48,267,444 (from NCBI)

This gene has 1 transcript (splice variant), 105 orthologues, 7 paralogues and is associated with 70 phenotypes. Restricted expression toward testis (RPKM 3.9).

功能概要

该基因的产物属于高度同源的滑膜肉瘤 X (SSX) 断点蛋白家族。这些蛋白质可能起到转录抑制因子的作用。它们还能够在癌症患者中引发自发的体液和细胞免疫反应，并且是基于癌症疫苗的免疫疗法的潜在有用靶点。该基因以及 SSX2 和 SSX4 家族成员参与了所有滑膜肉瘤中典型的 t (X;18) (p11.2;q11.2) 易位。这种易位导致 18 号染色体上的滑膜肉瘤易位基因与 X 染色体上的一个 SSX 基因融合。编码的杂合蛋白可能负责转化活性。该基因的可变剪接导致多个转录变体。已在 X 染色体上鉴定出一个相关的假基因。[RefSeq 提供，2013 年 7 月]

The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneous humoral and cellular immune responses in Cancer patients, and are potentially useful targets in Cancer vaccine-based immunotherapy. This gene, and also the SSX2 and SSX4 family members, have been involved in t(X;18)(p11.2;q11.2) translocations that are characteristically found in all synovial sarcomas. This translocation results in the fusion of the synovial sarcoma translocation gene on chromosome 18 to one of the SSX genes on chromosome X. The encoded hybrid proteins are likely responsible for transforming activity. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome X. [provided by RefSeq, Jul 2013]

SSX1 基因产物(2)

mRNA	Protein	Name
NM_001278691.2	NP_001265620.1	protein SSX1
NM_005635.4	NP_005626.1	protein SSX1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	25416956	GOA
enables transcription corepressor activity	IMP IMP: 通过突变表型推断	10072425	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	10072425	GOA
involved in spermatogenesis	IMP IMP: 通过突变表型推断	36796361	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in nucleus	IDA IDA: 通过直接分析推断	10072425	GOA
located in sperm flagellum	IMP IMP: 通过突变表型推断	36796361	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SSX1 蛋白结构

SSXRD

0
100
188 a.a.

蛋白主名

其他名称

protein SSX1

cancer/testis antigen 5.1

SSX1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	SSX1	Q16384	MTURN	Homo sapiens	Q8N3F0	Validated Y2H	32296183
种属内	SSX1	Q16384	CDCA7L	Homo sapiens	Q96GN5	Validated Y2H	32296183
种属内	SSX1	Q16384	MAGEC2	Homo sapiens	Q9UBF1	Validated Y2H	25416956

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Sarcoma, Synovial

Synovial Sarcoma	Synovialosarcoma
Synovial Cell Sarcoma	Sarcoma Synovial

Sarcoma

Connective And Soft Tissue Neoplasm	Tumor Of Soft Tissue And Skeleton
Sarcomas	Sarcoma - Category

Biphasic Synovial Sarcoma

Synovial Sarcoma, Biphasic

Biphasic Sarcoma Of Synovium

Spindle Cell Synovial Sarcoma

Synovial Sarcoma With Spindle Cell Components	Synovial Sarcoma, Monophasic Fibrous
Synovial Sarcoma, Spindle Cell

Epithelioid Cell Synovial Sarcoma

Synovial Sarcoma, Epithelioid Cell

Epithelioid Synovial Sarcoma

Monophasic Synovial Sarcoma

Monophasic Sarcoma Of Synovium

Tibial Adamantinoma

Tibial Adamantinoma Morphology

Adamantinoma Of Long Bones

Long Bone Adamantinoma

Synovium Cancer

Malignant Tumor Of Synovium

Synovial Neoplasm

Lung Sarcoma

Pulmonary Sarcoma

Spermatic Cord Cancer

Malignant Tumor Of Spermatic Cord	Malignant Tumor Of The Spermatic Cord
Spermatic Cord Ca	Malignant Neoplasm Of Spermatic Cord

Extraskeletal Mesenchymal Chondrosarcoma

Mesenchymal Extraosseous Chondrosarcoma

Synovium Neoplasm

Synovial Neoplasm

Tumor Of Synovium

Adult Cystic Nephroma

Multilocular Cystic Nephroma, Mixed Epithelial Stromal Tumour And Renal Epithelial Stromal Tumour

Ewing Sarcoma

Neuroepithelioma	Ewing'S Tumor
Primitive Neuroectodermal Tumor	Ewings Sarcoma
Ewing'S Sarcoma	Peripheral Neuroepithelioma
ES	Ewings Sarcoma-Primitive Neuroectodermal Tumor
Localized Peripheral Primitive Neuroectodermal Tumor	Peripheral Primitive Neuroectodermal Tumor
Ewing Tumor	Sarcoma, Ewing'S
Ewing Family Of Tumors	Extraosseous Ewing Tumor
Askin Tumor	Ewing'S Family Localized Tumor
Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor	Localized Ewing Sarcoma
Localized Ewing'S Sarcoma	Localized Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor
Localized Ewing'S Tumor	Pnet Of Thoracopulmonary Region
Tumor Of The Ewing Family	Skeletal Ewing Sarcoma
Osseous Ewing Sarcoma	Ppnet
Peripheral Pnet	Extraskeletal Ewing Sarcoma
Eoe	Extraosseous Ewing Sarcoma
Extraskeletal Ewing Tumor	Esft
Ewing Sarcoma Family Of Tumors	Pne
Pnet	Pnet Of The Chest Wall
Sarcoma, Ewing	Neuroectodermal Tumors, Primitive, Peripheral
Neuroectodermal Tumor, Primitive	Disorder Of Eye
Askin'S Tumor	Extraosseous Ewings Sarcoma-Primitive Neuroepithelial Tumor
Neuroepithelioma, Peripheral

Cellular Schwannoma

Cellular Neurinoma

Spindle Cell Sarcoma

Sarcoma	Sarcoma Spindle Cell
Sarcoma, Spindle Cell	Sarcoma - Category

Heart Sarcoma

Cardiac Sarcoma

Sarcoma Of Heart

Bone Angioendothelial Sarcoma

Osseous Hemangiosarcoma

Bone Angiosarcoma

Mediastinal Mesenchymal Tumor

Mediastinal Mesenchymal Tumour	Soft Tissue Tumor Of Mediastinum
Soft Tissue Tumour Of Mediastinum

Cellular Myxoid Liposarcoma

Round Cell Liposarcoma

Extraosseous Osteosarcoma

Extraskeletal Osteosarcoma

Extraskeletal Osteogenic Sarcoma

Hemangiopericytoma, Malignant

Hemangiopericytoma	Haemangiopericytic Meningioma
Malignant Hemangiopericytoma	Solitary Fibrous Tumor

Myxoid Liposarcoma

Myxoid/Round Cell Liposarcoma	Liposarcoma, Myxoid
Mrcls	Myxoliposarcoma
MXLIPO	Liposarcoma Myxoid
Liposarcoma

Juxtacortical Chondroma

Periosteal Chondroma

Pleomorphic Liposarcoma

Pls	Liposarcoma Pleomorphic
Liposarcoma, Pleomorphic

Kidney Sarcoma

Renal Sarcoma

Sarcoma Of Kidney

Extraosseous Chondrosarcoma

Extraskeletal Myxoid Chondrosarcoma

Dedifferentiated Liposarcoma

Ddls	Liposarcoma Dedifferentiated
Liposarcoma, Dedifferentiated

Thymus Sarcomatoid Carcinoma

Thymic Carcinosarcoma

Thymic Sarcomatoid Carcinoma

Myxofibrosarcoma

Fibromyxosarcoma	Fibromyxoid Sarcoma
Myxoid Malignant Fibrous Histiocytoma	Dermatofibrosarcoma Protuberans, Myxoid

Sarcomatoid Mesothelioma

Malignant Fibrous Mesothelioma

Spindled Mesothelioma

Alveolar Soft Part Sarcoma

ASPS	Alveolar Soft-Part Sarcoma
Sarcoma, Alveolar Soft Part	Alveolar Soft Tissue Sarcoma
Sarcoma Alveolar Soft Part	Adult Alveolar Soft-Part Sarcoma
Childhood Alveolar Soft-Part Sarcoma

Kidney Fibrosarcoma

Fibrosarcoma Of The Kidney

Dermatofibrosarcoma Protuberans

DFSP	Dermatofibrosarcoma
Giant Cell Fibroblastoma	Metastatic Dermatofibrosarcoma Protuberans
Familial Dermatofibrosarcoma Protuberans	Darier-Ferrand Tumor
Darier-Hoffmann Tumor

Chondrosarcoma, Extraskeletal Myxoid

Extraskeletal Myxoid Chondrosarcoma	Emc
Myxoid Extraosseous Chondrosarcoma

Rhabdomyosarcoma

Well-Differentiated Liposarcoma

Atypical Lipomatous Tumor	Atypical Lipoma
Alt	Wdls
Liposarcoma, Well Differentiated	Pleomorphic Lipoma

Desmoplastic Small Round Cell Tumor

Dsrct	Desmoplastic Small Round-Cell Tumor
Desmoplastic Small Round-Cell Neoplasm

Muscle Cancer

Myosarcoma	Malignant Neoplasm Of Muscle
Malignant Tumor Of Muscle	Malignant Tumor Of The Muscle
Muscle Neoplasms	Myomatous Neoplasm

Skeletal Muscle Cancer

Malignant Tumor Of Skeletal Muscle

Skeletal Muscle Neoplasm

Rhabdomyosarcoma 2

Alveolar Rhabdomyosarcoma	Rhabdomyosarcoma, Alveolar
Rhabdomyosarcoma Alveolar	RMS2
Rmsa	Rhabdomyosarcoma 2, Alveolar
Alveolar Childhood Rhabdomyosarcoma	Arms
Rhabdomyosarcoma, Type 2

Kidney Clear Cell Sarcoma

Clear Cell Sarcoma Of Kidney	Childhood Kidney Clear Cell Sarcoma
Renal Clear Cell Sarcoma	Ccsk
Clear Cell Sarcoma Of The Kidney

Inflammatory Myofibroblastic Tumor

Inflammatory Fibrosarcoma

Bone Osteosarcoma

Osteosarcoma Of Bone

Primary Osteosarcoma Of Bone

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2025 MedChemExpress. All Rights Reserved.

SSX1 - SSX family member 1 Gene

关于 SSX1

功能概要

SSX1 基因产物(2)

SSX1 蛋白结构

SSX1 蛋白互作信息

关联疾病

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

SSX1 - SSX family member 1 Gene

关于 SSX1

功能概要

SSX1 基因产物(2)

SSX1 蛋白结构

SSX1 蛋白互作信息

关联疾病

相关产品

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z