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  2. SSX2 - SSX family member 2 Gene

SSX2 - SSX family member 2 Gene

中文名称:SSX 家族成员 2

种属: Homo sapiens

同用名: SSX; HD21; CT5.2; CT5.2A; HOM-MEL-40

基因 ID: 6757 | 基因类型: protein coding

关于 SSX2

Cytogenetic location: Xp11.22 Genomic coordinates (GRCh38): X:52,696,896-52,707,227 (from NCBI)

This gene has 3 transcripts (splice variants), 101 orthologues, 7 paralogues and is associated with 28 phenotypes. Restricted expression toward testis (RPKM 18.4).

功能概要

该基因的产物属于高度同源的滑膜肉瘤 X (SSX) 断点蛋白家族。这些蛋白质可能起到转录抑制因子的作用。它们还能够在癌症患者中引发自发的体液和细胞免疫反应,并且是基于癌症疫苗的免疫疗法的潜在有用靶点。该基因以及 SSX1 和 SSX4 家族成员都参与了所有滑膜肉瘤中常见的 t (X;18) (p11.2;q11.2) 易位。这种易位导致 18 号染色体上的滑膜肉瘤易位基因与 X 染色体上的一个 SSX 基因融合。编码的杂合蛋白可能负责转化活性。该基因的可变剪接导致多个转录变体。该基因也有一个相同的副本,GeneID:727837,位于 X 染色体相反方向的下游约 45 kb。[RefSeq 提供,2013 年 7 月]

The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneous humoral and cellular immune responses in Cancer patients, and are potentially useful targets in Cancer vaccine-based immunotherapy. This gene, and also the SSX1 and SSX4 family members, have been involved in t(X;18)(p11.2;q11.2) translocations that are characteristically found in all synovial sarcomas. This translocation results in the fusion of the synovial sarcoma translocation gene on chromosome 18 to one of the SSX genes on chromosome X. The encoded hybrid proteins are likely responsible for transforming activity. Alternative splicing of this gene results in multiple transcript variants. This gene also has an identical duplicate, GeneID: 727837, located about 45 kb downstream in the opposite orientation on chromosome X. [provided by RefSeq, Jul 2013]

SSX2 基因产物(3)

mRNA Protein Name
NM_001278697.2 NP_001265626.1 protein SSX2 isoform c
NM_003147.6 NP_003138.3 protein SSX2 isoform a
NM_175698.4 NP_783629.1 protein SSX2 isoform b

SSX2 蛋白结构

KRAB

KRAB: KRAB box (25 - 48)

SSXRD

SSXRD: SSXRD motif (155 - 188)

  • 0
  • 100
  • 188 a.a.
蛋白主名 其他名称

protein SSX2

cancer/testis antigen 5.2

SSX2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
SSX2 Q16385 KRT40 Homo sapiens Q6A162 25416956
种属内
SSX2 Q16385 KRT40 Homo sapiens Q6A162 25416956
种属内
SSX2 Q16385 ZMIZ2 Homo sapiens Q8NF64-2 25416956
种属内
SSX2 Q16385 SSX2IP Homo sapiens Q9Y2D8 12007189
种属内
SSX2 Q16385 SSX2IP Homo sapiens Q9Y2D8
IF
12007189
种属内
SSX2 Q16385 SSX2IP Homo sapiens Q9Y2D8
Y2H
12007189
种属内
SSX2 Q16385 SPRED1 Homo sapiens Q7Z699 32814053
种属内
SSX2 Q16385 SPRED1 Homo sapiens Q7Z699 32814053
种属内
SSX2 Q16385 SPRED1 Homo sapiens Q7Z699 32814053
种属内
SSX2 Q16385 TAX1BP1 Homo sapiens Q86VP1 25416956
种属内
SSX2 Q16385 SYCE1 Homo sapiens Q8N0S2 25416956
种属内
SSX2 Q16385 ZBED1 Homo sapiens O96006 25416956
种属内
SSX2 Q16385 ZBED1 Homo sapiens O96006 25416956
种属内
SSX2 Q16385 RAB3IP Homo sapiens Q96QF0 25416956
种属内
SSX2 Q16385 RAB3IP Homo sapiens Q96QF0 25416956
种属内
SSX2 Q16385 RAB3IP Homo sapiens Q96QF0 25416956
种属内
SSX2 Q16385 RAB3IP Homo sapiens Q96QF0-2
IF
12007189
种属内
SSX2 Q16385 AKAP9 Homo sapiens Q99996-2 25416956
种属内
SSX2 Q16385 AKAP9 Homo sapiens Q99996-2 28514442
种属内
SSX2 Q16385 AKAP9 Homo sapiens Q99996-2 25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Sarcoma, Synovial

Synovial Sarcoma

Synovialosarcoma

Synovial Cell Sarcoma

Sarcoma Synovial

Sarcoma

Connective And Soft Tissue Neoplasm

Tumor Of Soft Tissue And Skeleton

Sarcomas

Sarcoma - Category

Monophasic Synovial Sarcoma

Monophasic Sarcoma Of Synovium

Synovium Cancer

Malignant Tumor Of Synovium

Synovial Neoplasm

Lung Sarcoma

Pulmonary Sarcoma

Biphasic Synovial Sarcoma

Synovial Sarcoma, Biphasic

Biphasic Sarcoma Of Synovium

Seminoma

Seminoma, Pure

Malignant Glandular Tumor Of Peripheral Nerve Sheath

Glandular Mpnst

Glandular Malignant Peripheral Nerve Sheath Tumor

Spindle Cell Synovial Sarcoma

Synovial Sarcoma With Spindle Cell Components

Synovial Sarcoma, Monophasic Fibrous

Synovial Sarcoma, Spindle Cell

Epithelioid Cell Synovial Sarcoma

Synovial Sarcoma, Epithelioid Cell

Epithelioid Synovial Sarcoma

Sarcomatoid Renal Cell Carcinoma

Renal Cell Carcinoma, Spindle Cell

Testicular Cancer

Testis Cancer

Testicular Carcinoma

Testicular Neoplasms

Malignant Neoplasm Of Testis

Childhood Neoplasm Of The Testis

Neoplasm Of Testis

Pediatric Testicular Neoplasm

Testicular Tumor

Testis Neoplasm

Testicular Tumors

Testicular Neoplasm

Testicular Malignant Germ Cell Tumor

Childhood Testicular Neoplasm

Carcinoma Of The Testis

Cancer Of Testis

Malignant Neoplasm Of Testis, Nos

Malignant Neoplasm Of Testis, Unspecified

Malignant Tumour Of Testis

Testicle Cancer

Primary Malignant Neoplasm Of Testis

Liver Fibroma

Fibroma Of The Liver

Liver Solitary Fibrous Tumor

Kidney Hemangiopericytoma

Hemangiopericytoma Of Kidney

Renal Hemangiopericytoma

Cellular Neurofibroma
Spindle Cell Thymoma

Medullary Thymoma

Thymoma, Medullary

Thymoma, Type A

Kidney Sarcoma

Renal Sarcoma

Sarcoma Of Kidney

Extraskeletal Mesenchymal Chondrosarcoma

Mesenchymal Extraosseous Chondrosarcoma

Heart Sarcoma

Cardiac Sarcoma

Sarcoma Of Heart

Spindle Cell Sarcoma

Sarcoma

Sarcoma Spindle Cell

Sarcoma, Spindle Cell

Sarcoma - Category

Epithelioid Malignant Peripheral Nerve Sheath Tumor

Epithelioid Mpnst

Malignant Epithelioid Neoplasm Of The Peripheral Nerve Sheath

Malignant Mesenchymoma

Malignant Mesenchymal Tumor

Mesenchymoma, Malignant

Sarcoma

Rat Malignant Renal Mesenchymal Tumor

Myxofibrosarcoma

Fibromyxosarcoma

Fibromyxoid Sarcoma

Myxoid Malignant Fibrous Histiocytoma

Dermatofibrosarcoma Protuberans, Myxoid

Sarcomatoid Mesothelioma

Malignant Fibrous Mesothelioma

Spindled Mesothelioma

Spermatic Cord Cancer

Malignant Tumor Of Spermatic Cord

Malignant Tumor Of The Spermatic Cord

Spermatic Cord Ca

Malignant Neoplasm Of Spermatic Cord

Extraosseous Chondrosarcoma

Extraskeletal Myxoid Chondrosarcoma

Well-Differentiated Liposarcoma

Atypical Lipomatous Tumor

Atypical Lipoma

Alt

Wdls

Liposarcoma, Well Differentiated

Pleomorphic Lipoma

Desmoplastic Small Round Cell Tumor

Dsrct

Desmoplastic Small Round-Cell Tumor

Desmoplastic Small Round-Cell Neoplasm

Hemangiopericytoma, Malignant

Hemangiopericytoma

Haemangiopericytic Meningioma

Malignant Hemangiopericytoma

Solitary Fibrous Tumor

Chondrosarcoma, Extraskeletal Myxoid

Extraskeletal Myxoid Chondrosarcoma

Emc

Myxoid Extraosseous Chondrosarcoma

Meninges Sarcoma

Meningeal Sarcoma

Sarcoma Of Meninges

Meningothelial Sarcoma

Leptomeningeal Sarcoma

Dedifferentiated Liposarcoma

Ddls

Liposarcoma Dedifferentiated

Liposarcoma, Dedifferentiated

Spermatocytoma

Spermatocytic Seminoma

Pleomorphic Liposarcoma

Pls

Liposarcoma Pleomorphic

Liposarcoma, Pleomorphic

Myxoid Liposarcoma

Myxoid/Round Cell Liposarcoma

Liposarcoma, Myxoid

Mrcls

Myxoliposarcoma

MXLIPO

Liposarcoma Myxoid

Liposarcoma

Muscle Cancer

Myosarcoma

Malignant Neoplasm Of Muscle

Malignant Tumor Of Muscle

Malignant Tumor Of The Muscle

Muscle Neoplasms

Myomatous Neoplasm

Ovarian Angiosarcoma

Hemangiosarcoma Of Ovary

Clear Cell Sarcoma

Sarcoma, Clear Cell

Adult Soft Part Clear Cell Sarcoma

Clear Cell Sarcoma Of Soft Parts

Malignant Melanoma Of Soft Parts

Malignant Melanoma Of Soft Tissues

Melanoma, Malignant, Of Soft Parts

Sarcoma Clear Cell

Myxoid Chondrosarcoma
Synovium Neoplasm

Synovial Neoplasm

Tumor Of Synovium

Cellular Myxoid Liposarcoma

Round Cell Liposarcoma

Perivascular Tumor

Malignant Perivascular Cancer

Skeletal Muscle Cancer

Malignant Tumor Of Skeletal Muscle

Skeletal Muscle Neoplasm

Alveolar Soft Part Sarcoma

ASPS

Alveolar Soft-Part Sarcoma

Sarcoma, Alveolar Soft Part

Alveolar Soft Tissue Sarcoma

Sarcoma Alveolar Soft Part

Adult Alveolar Soft-Part Sarcoma

Childhood Alveolar Soft-Part Sarcoma

Epithelioid Sarcoma

Epithelioid Cell Sarcoma

Sarcoma Epithelioid

Sarcoma, Epithelioid

Mesenchymal Cell Neoplasm

Benign Miscellaneous Mesenchymal Tumor

Mesenchymal Tumor

Mesenchymal Tumors

Rhabdomyosarcoma
Pyriform Sinus Cancer

Malignant Neoplasm Of Pyriform Fossa

Malignant Neoplasm Of The Pyriform Fossa

Malignant Tumor Of Pyriform Fossa

Dermatofibrosarcoma Protuberans

DFSP

Dermatofibrosarcoma

Giant Cell Fibroblastoma

Metastatic Dermatofibrosarcoma Protuberans

Familial Dermatofibrosarcoma Protuberans

Darier-Ferrand Tumor

Darier-Hoffmann Tumor

Kidney Cortex Disease
Rhabdoid Cancer

Rhabdoid Tumor

Malignant Rhabdoid Tumor

Malignant Rhabdoid Tumour

Rhabdoid Sarcoma

Rhabdoid Tumor Predisposition Syndrome 1

Rhabdoid Tumor Predisposition Syndrome 2

Atypical Teratoid Rhabdoid Tumor

Brain Tumor, Posterior Fossa, Of Infancy, Familial

Atypical Teratoid/Rhabdoid Tumor

Rhabdomyosarcoma 2

Alveolar Rhabdomyosarcoma

Rhabdomyosarcoma, Alveolar

Rhabdomyosarcoma Alveolar

RMS2

Rmsa

Rhabdomyosarcoma 2, Alveolar

Alveolar Childhood Rhabdomyosarcoma

Arms

Rhabdomyosarcoma, Type 2

Melanoma

Malignant Melanoma

Cutaneous Melanoma

Naevocarcinoma

Malignant Melanomas

Congenital Mesoblastic Nephroma

Mesoblastic Nephroma

Nephroma, Mesoblastic

Thymus Sarcomatoid Carcinoma

Thymic Carcinosarcoma

Thymic Sarcomatoid Carcinoma

Kidney Fibrosarcoma

Fibrosarcoma Of The Kidney

Inflammatory Myofibroblastic Tumor

Inflammatory Fibrosarcoma

Embryonal Rhabdomyosarcoma

Rhabdomyosarcoma, Embryonal

Rhabdomyosarcoma Embryonal

Botryoid Rhabdomyosarcoma

Erms

Spindle Cell Rhabdomyosarcomas

Neurilemmomatosis

Schwannomatosis

Neurofibromatosis Type 3

Nf3

Neurilemmomatosis Congenital Cutaneous

Neurinomatosis

Congenital Cutaneous Neurilemmomatosis

Multiple Neurilemmomas

Multiple Schwannomas

Neurilemmomatosis, Congenital Cutaneous

Schwannomatosis 1

Neurofibromatosis 3

Mixed Central And Peripheral Neurofibromatosis

Nf3 - [Neurofibromatosis Type 3]

Endometrial Stromal Sarcoma

Ess

Endometrial Stromal Sarcoma, High Grade

Undifferentiated Endometrial Sarcoma

Stromal Sarcoma Of The Corpus Uteri

Sarcoma Endometrial Stromal

Sarcoma, Endometrial Stromal

Undifferentiated Stromal Sarcoma

Ewing Sarcoma

Neuroepithelioma

Ewing'S Tumor

Primitive Neuroectodermal Tumor

Ewings Sarcoma

Ewing'S Sarcoma

Peripheral Neuroepithelioma

ES

Ewings Sarcoma-Primitive Neuroectodermal Tumor

Localized Peripheral Primitive Neuroectodermal Tumor

Peripheral Primitive Neuroectodermal Tumor

Ewing Tumor

Sarcoma, Ewing'S

Ewing Family Of Tumors

Extraosseous Ewing Tumor

Askin Tumor

Ewing'S Family Localized Tumor

Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor

Localized Ewing Sarcoma

Localized Ewing'S Sarcoma

Localized Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor

Localized Ewing'S Tumor

Pnet Of Thoracopulmonary Region

Tumor Of The Ewing Family

Skeletal Ewing Sarcoma

Osseous Ewing Sarcoma

Ppnet

Peripheral Pnet

Extraskeletal Ewing Sarcoma

Eoe

Extraosseous Ewing Sarcoma

Extraskeletal Ewing Tumor

Esft

Ewing Sarcoma Family Of Tumors

Pne

Pnet

Pnet Of The Chest Wall

Sarcoma, Ewing

Neuroectodermal Tumors, Primitive, Peripheral

Neuroectodermal Tumor, Primitive

Disorder Of Eye

Askin'S Tumor

Extraosseous Ewings Sarcoma-Primitive Neuroepithelial Tumor

Neuroepithelioma, Peripheral

Gastrointestinal Stromal Tumor

GIST

Gastrointestinal Stromal Tumors

Gastrointestinal Stromal Sarcoma

Gastrointestinal Stromal Tumor, Familial

Gant

Gastrointestinal Stromal Tumour

Stromal Tumor Of Gastrointestinal Tract

Stromal Tumour Of Gastrointestinal Tract

Gastrointestinal Stromal Neoplasm

Paraganglioma And Gastric Stromal Sarcoma

Plexosarcoma

Bone Osteosarcoma

Osteosarcoma Of Bone

Primary Osteosarcoma Of Bone

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma