TAX1BP1 - Tax1 binding protein 1 Gene

中文名称：Tax1 结合蛋白 1

种属: Homo sapiens

同用名: T6BP; TXBP151; CALCOCO3

关于 TAX1BP1

功能概要

该基因编码 HTLV-1 tax1 结合蛋白。编码的蛋白质与 TNFAIP3 相互作用，并通过介导 TNFAIP3 抗细胞凋亡活性来抑制 TNF 诱导的细胞凋亡。 Caspase-3 样家族蛋白对这种蛋白的降解与 TNF 诱导的细胞凋亡有关。这种蛋白质也可能在抑制炎症信号通路方面发挥作用。已发现该基因编码不同亚型的可变剪接转录本变体。[RefSeq 提供，2011 年 5 月]

This gene encodes a HTLV-1 tax1 binding protein. The encoded protein interacts with TNFAIP3, and inhibits TNF-induced Apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degradation of this protein by caspase-3-like family proteins is associated with Apoptosis induced by TNF. This protein may also have a role in the inhibition of inflammatory signaling pathways. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2011]