COG7 - component of oligomeric golgi complex 7 Gene

中文名称：低聚高尔基复合体 7 的成分

种属: Homo sapiens

同用名: CDG2E

基因 ID: 91949 | 基因类型: protein coding

关于 COG7

Cytogenetic location: 16p12.2 Genomic coordinates (GRCh38): 16:23,388,493-23,453,189 (from NCBI)

This gene has 6 transcripts (splice variants), 209 orthologues and is associated with 3 phenotypes. Ubiquitous expression in thyroid (RPKM 7.2), prostate (RPKM 6.0) and 25 other tissues.

功能概要

由该基因编码的蛋白质存在于高尔基体中，构成保守的低聚高尔基体 (COG) 复合体的 8 个亚基之一，这是正常高尔基体形态和定位所必需的。该基因的突变与 IIe 型糖基化先天性疾病有关。[RefSeq 提供，2010 年 5 月]

The protein encoded by this gene resides in the golgi, and constitutes one of the 8 subunits of the conserved oligomeric Golgi (COG) complex, which is required for normal golgi morphology and localization. Mutations in this gene are associated with the congenital disorder of glycosylation type IIe.[provided by RefSeq, May 2010]

COG7 基因产物(1)

mRNA	Protein	Name
NM_153603.4	NP_705831.1	conserved oligomeric Golgi complex subunit 7

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	15047703	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in Golgi organization	IMP IMP: 通过突变表型推断	27066481	GOA
involved in glycosylation	IMP IMP: 通过突变表型推断	27066481	GOA
involved in intracellular protein transport	IMP IMP: 通过突变表型推断	15107842	GOA
involved in protein glycosylation	IMP IMP: 通过突变表型推断	15107842	GOA
involved in protein localization to Golgi apparatus	IMP IMP: 通过突变表型推断	16510524	GOA
involved in protein localization to organelle	IMP IMP: 通过突变表型推断	16420527	GOA
involved in protein stabilization	IMP IMP: 通过突变表型推断	16420527	GOA
involved in retrograde transport, vesicle recycling within Golgi	IMP IMP: 通过突变表型推断	27066481	GOA
involved in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	IMP IMP: 通过突变表型推断	16420527	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in Golgi apparatus	IDA IDA: 通过直接分析推断	11980916	GOA
part of Golgi transport complex	IDA IDA: 通过直接分析推断	15047703	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

COG7 蛋白结构

COG7

0
200
400
600
770 a.a.

蛋白主名

其他名称

conserved oligomeric Golgi complex subunit 7

COG complex subunit 7

COG7 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	COG7	P83436	KIFC3	Homo sapiens	Q9BVG8-5	Y2H Array	32296183
Intra	COG7	P83436	KIFC3	Homo sapiens	Q9BVG8-5	Y2H Prey Pooling	26871637
Intra	COG7	P83436	KIFC3	Homo sapiens	Q9BVG8-5	Y2H Prey Pooling	32296183
Intra	COG7	P83436	KIFC3	Homo sapiens	Q9BVG8-5	Validated Y2H	26871637
Intra	COG7	P83436	KIFC3	Homo sapiens	Q9BVG8-5	Validated Y2H	32296183
Intra	COG7	P83436	KIFC3	Homo sapiens	Q9BVG8-5	Y2H Array	26871637
Intra	COG7	P83436	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	26871637
Intra	COG7	P83436	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	26871637
Intra	COG7	P83436	MEOX2	Homo sapiens	Q6FHY5	Validated Y2H	26871637
Intra	COG7	P83436	COG4	Homo sapiens	Q9H9E3	CoIP	15047703
Intra	COG7	P83436	COG4	Homo sapiens	Q9H9E3	Anti Bait CoIP	19536132
Intra	COG7	P83436	COG4	Homo sapiens	Q9H9E3	Anti Tag CoIP	33961781
Intra	COG7	P83436	COG5	Homo sapiens	Q9UP83	CoIP	15047703
Intra	COG7	P83436	COG5	Homo sapiens	Q9UP83	Anti Tag CoIP	33961781
Intra	COG7	P83436	TAX1BP1	Homo sapiens	Q86VP1	Y2H Array	32296183
Intra	COG7	P83436	TAX1BP1	Homo sapiens	Q86VP1	Validated Y2H	26871637
Intra	COG7	P83436	TAX1BP1	Homo sapiens	Q86VP1	Y2H Array	26871637
Intra	COG7	P83436	TAX1BP1	Homo sapiens	Q86VP1	Validated Y2H	25416956
Intra	COG7	P83436	TAX1BP1	Homo sapiens	Q86VP1	Validated Y2H	32296183
Intra	COG7	P83436	TAX1BP1	Homo sapiens	Q86VP1	Y2H Prey Pooling	26871637
Intra	COG7	P83436	TAX1BP1	Homo sapiens	Q86VP1	Y2H Prey Pooling	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Immunodeficiency 47

Congenital Disorder Of Glycosylation Type Ii	CDG2E
Congenital Disorder Of Glycosylation Type Iie	IMD47
Cdg2s	Cdg Iis
Cdgiis	Immunodeficiency And Hepatopathy With Or Without Neurologic Features
Congenital Disorder Of Glycosylation, Type Ii	CDG1I
Congenital Disorder Of Glycosylation, Type Iie	Cdg Iie
Congenital Disorder Of Glycosylation Type 2e	Congenital Disorder Of Glycosylation, Type Iis
Cdg Ii	Cdgii
Cdgiie	Carbohydrate Deficient Glycoprotein Syndrome Type Iie
Cdg Syndrome Type Iie	Congenital Disorder Of Glycosylation Ii
Congenital Disorder Of Glycosylation 1i	Cdg-Iie
Alg2-Cdg	Cdg-Ii
Glycosylation, Congenital Disorder Of, Type Ii	Cdgiide
Congenital Disorder Of Glycosylation Type Iis	Cog7-Cdg
Cdg Syndrome Type Ii	Carbohydrate Deficient Glycoprotein Syndrome Type Ii
Congenital Disorder Of Glycosylation Type 1i	Mannosyltransferase 2 Deficiency
Congenital Disorder Of Glycosylation 2e	Congenital Disorder Of Glycosylation 2s
Congenital Disorders Of Glycosylation Type Ii	Glycosylation, Congenital Disorder Of, Type Iie
Immunodeficiency, Type 47	Congenital Disorder Of Glycosylation Type 2a

Congenital Disorder Of Glycosylation, Type Iih

CDG2H	Congenital Disorder Of Glycosylation Type Iih
Cdg Iih	Cdgiih
Carbohydrate Deficient Glycoprotein Syndrome Type Iih	Congenital Disorder Of Glycosylation Type 2h
Cog8-Cdg	Cdg-Iih
Cdgiidh	Cdg Syndrome Type Iih
Congenital Disorder Of Glycosylation 2h	Glycosylation, Congenital Disorder Of, Type Iih

Congenital Disorder Of Glycosylation, Type Iij

CDG2J	Congenital Disorder Of Glycosylation Type Iij
Cdg Iij	Cdgiij
Carbohydrate Deficient Glycoprotein Syndrome Type Iij	Cdg Syndrome Type Iij
Congenital Disorder Of Glycosylation Type 2j	Cog4-Cdg
Cdg-Iij	Cdgiidj
Congenital Disorder Of Glycosylation 2j	Glycosylation, Congenital Disorder Of, Type Iij

Congenital Disorder Of Glycosylation, Type Iii

CDG2I	Congenital Disorder Of Glycosylation Type Iii
Cdgiii	Carbohydrate Deficient Glycoprotein Syndrome Type Iii
Congenital Disorder Of Glycosylation Type 2i	Cog5-Cdg
Cdgiidi	Congenital Disorder Of Glycosylation 2i
Glycosylation, Congenital Disorder Of, Type Iii	Congenital Disorder Of Glycosylation, Type I-Iix

Congenital Disorder Of Glycosylation, Type Iil

CDG2L	Congenital Disorder Of Glycosylation Type Iil
Cdg Iil	Cog6-Cgd
Cdgiil	Cdg Syndrome Type Iil
Congenital Disorder Of Glycosylation Type 2l	Cdg-Iil
Cdgiidl	Congenital Disorder Of Glycosylation 2l
Glycosylation, Congenital Disorder Of, Type Iil

White-Sutton Syndrome

WHSUS	Mrd37
Intellectual Disability-Microcephaly-Strabismus-Behavioral Abnormalities Syndrome	Mental Retardation, Autosomal Dominant 37
Autosomal Dominant Mental Retardation 37	Pogz-Related Intellectual Disability Syndrome

Saul-Wilson Syndrome

Microcephalic Osteodysplastic Dysplasia	Microcephalic Osteodysplastic Dysplasia, Saul-Wilson Type
SWILS	Microcephalic Osteodysplastic Dysplasia Saul Wilson Type

Geroderma Osteodysplasticum

Gerodermia Osteodysplastica	Geroderma Osteodysplastica
GO	Walt Disney Dwarfism
Type Of Gerodermia Osteodysplastica

Congenital Disorder Of Glycosylation, Type In

Congenital Disorder Of Glycosylation	CDG1N
Congenital Disorders Of Glycosylation	Cdg In
Cdgin	Congenital Disorder Of Glycosylation 1n
Carbohydrate-Deficient Glycoprotein Syndrome	Cdg
Rft1-Cdg	Cdg-In
Congenital Disorder Of Glycosylation Type In	Carbohydrate Deficient Glycoprotein Syndrome
Cdg Syndrome	Congenital Disorder Of Glycosylation In
Carbohydrate-Deficient Glycoprotein Syndromes	Cdg Syndrome Type In
Carbohydrate Deficient Glycoprotein Syndrome Type In	Congenital Disorder Of Glycosylation Type 1n
Man5glcnac2-Pp-Dol Flippase Deficiency	Glycosylation, Congenital Disorder Of
Glycosylation, Congenital Disorder Of, Type In

Granulomatous Disease, Chronic, X-Linked

CGDX	Chronic Granulomatous Disease, X-Linked
X-Linked Chronic Granulomatous Disease	Cgd
Cytochrome B-Negative Granulomatous Disease, Chronic, X-Linked	Cdgx
X-Linked Chronic Cytochrome B-Negative Granulomatous Disease	Chronic Granulomatous Disease Cytochrome B-Negative X-Linked
Chronic Granulomatous Disease Cytochrome B-Positive X-Linked	Granulomatous Disease, Chronic, X-Linked, Variant

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS02956	COG7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	COG7	MGD	MGI:2685013
Felis catus	COG7	VGNC	VGNC:61050
Rattus norvegicus	COG7	RGD	RGD:1566058
Macaca mulatta	COG7	VGNC	VGNC:71208
Bos taurus	COG7	VGNC	VGNC:27551
Canis familiaris	COG7	VGNC	VGNC:39453

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

COG7 - component of oligomeric golgi complex 7 Gene

关于 COG7

功能概要

COG7 基因产物(1)

COG7 蛋白结构

COG7 蛋白互作信息

关联疾病

直系同源

热门区域

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COG7 - component of oligomeric golgi complex 7 Gene

关于 COG7

功能概要

COG7 基因产物(1)

COG7 蛋白结构

COG7 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z