2. Gene
  3. RAD18 - RAD18 E3 ubiquitin protein ligase Gene

RAD18 - RAD18 E3 ubiquitin protein ligase Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：RAD18 E3 泛素蛋白连接酶

种属: Homo sapiens

同用名: RNF73

基因 ID: 56852 | 基因类型: protein coding

关于 RAD18

Cytogenetic location: 3p25.3 Genomic coordinates (GRCh38): 3:8,877,075-8,963,472 (from NCBI)

This gene has 10 transcripts (splice variants) and 199 orthologues. Ubiquitous expression in duodenum (RPKM 3.3), lymph node (RPKM 2.7) and 25 other tissues.

功能概要

该基因编码的蛋白质与酿酒酵母 DNA 损伤修复蛋白 Rad18 高度相似。酵母 Rad18 通过与 Rad6 的相互作用发挥作用，Rad6 是一种泛素结合酶，是受损 DNA 复制后修复所需的。与其酵母对应物类似，该蛋白质能够通过保守的无名指基序与酵母 Rad6 蛋白的人类同系物相互作用。该基序的突变导致受紫外线损伤的 DNA 复制缺陷和对多种诱变剂的超敏反应。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is highly similar to S. cerevisiae DNA damage repair protein Rad18. Yeast Rad18 functions through its interaction with Rad6, which is an ubiquitin-conjugating Enzyme required for post-replication repair of damaged DNA. Similar to its yeast counterpart, this protein is able to interact with the human homolog of yeast Rad6 protein through a conserved ring-finger motif. Mutation of this motif results in defective replication of UV-damaged DNA and hypersensitivity to multiple mutagens. [provided by RefSeq, Jul 2008]

RAD18 基因产物(1)

mRNA Protein Name
NM_020165.4 NP_064550.3 E3 ubiquitin-protein ligase RAD18
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables Y-form DNA binding IDA
IDA: 通过直接分析推断
18363965 GOA
enables identical protein binding IDA
IDA: 通过直接分析推断
25023518 GOA
enables polyubiquitin modification-dependent protein binding IDA
IDA: 通过直接分析推断
22742833 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
18316726 GOA
enables protein-containing complex binding IPI
IPI: 通过物理相互作用推断
25931565 GOA
enables ubiquitin protein ligase binding IPI
IPI: 通过物理相互作用推断
10908344 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within DNA damage response IDA
IDA: 通过直接分析推断
25023518 GOA
involved in DNA damage response IDA
IDA: 通过直接分析推断
22036607 GOA
involved in positive regulation of chromosome segregation IMP
IMP: 通过突变表型推断
25931565 GOA
acts upstream of or within protein autoubiquitination IDA
IDA: 通过直接分析推断
25023518 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in centrosome IDA
IDA: 通过直接分析推断
15632077 GOA
located in nuclear inclusion body IDA
IDA: 通过直接分析推断
22036607 GOA
located in nucleus IDA
IDA: 通过直接分析推断
15632077 GOA
located in replication fork IDA
IDA: 通过直接分析推断
18363965 GOA
located in site of double-strand break IDA
IDA: 通过直接分析推断
25931565 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RAD18 蛋白结构

zf-C3HC4

zf-C3HC4: Zinc finger, C3HC4 type (RING finger) (25 - 63)

SAP

SAP: SAP domain (248 - 281)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 495 a.a.
蛋白主名 其他名称

E3 ubiquitin-protein ligase RAD18

RAD18 homolog

RAD18 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra RAD18 Q9NS91 HLTF Homo sapiens Q14527
Anti Tag CoIP
18719106
Intra RAD18 Q9NS91 UBE2A Homo sapiens P49459
TAP
24981860
Intra RAD18 Q9NS91 UBE2A Homo sapiens P49459
Anti Tag CoIP
26496610
Intra RAD18 Q9NS91 ARRDC3 Homo sapiens Q96B67
Y2H Prey Pooling
32296183
Intra RAD18 Q9NS91 ARRDC3 Homo sapiens Q96B67
Y2H Array
32296183
Intra RAD18 Q9NS91 ORC2 Homo sapiens Q13416
Y2H Array
32296183
Intra RAD18 Q9NS91 ORC2 Homo sapiens Q13416
Y2H Prey Pooling
32296183
Intra RAD18 Q9NS91 TAX1BP1 Homo sapiens Q86VP1
Validated Y2H
25416956
Intra RAD18 Q9NS91 TAX1BP1 Homo sapiens Q86VP1
Y2H Array
25416956
Intra RAD18 Q9NS91 TAX1BP1 Homo sapiens Q86VP1
Y2H Array
32296183
Intra RAD18 Q9NS91 TAX1BP1 Homo sapiens Q86VP1
Y2H Prey Pooling
32296183
Intra RAD18 Q9NS91 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
32296183
Intra RAD18 Q9NS91 GOLGA2 Homo sapiens Q08379
Y2H Array
32296183
Intra RAD18 Q9NS91 UBE2B Homo sapiens P63146
Y2H Array
19549727
Intra RAD18 Q9NS91 UBE2B Homo sapiens P63146
Y2H
19549727
Intra RAD18 Q9NS91 DAZAP2 Homo sapiens Q15038
Y2H Prey Pooling
32296183
Intra RAD18 Q9NS91 DAZAP2 Homo sapiens Q15038
Y2H Array
32296183
Intra RAD18 Q9NS91 MAGEA4 Homo sapiens P43358
Y2H Prey Pooling
32296183
Intra RAD18 Q9NS91 MAGEA4 Homo sapiens P43358
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Xeroderma Pigmentosum, Variant Type

Xeroderma Pigmentosum

XPV

Xeroderma Pigmentosum Variant Type

Xeroderma Pigmentosum With Normal Dna Repair Rates

Photosensitivity With Defective Dna Synthesis

Xp

De Sanctis-Cacchione Syndrome

Desanctis-Cacchione Syndrome

Xeroderma Pigmentosa

Xerodermic Idiocy

Xeroderma Pigmentosum Variant

Xp - [Xeroderma Pigmentosum]

Atrophoderma Pigmentosum
Cornelia De Lange Syndrome

De Lange Syndrome

Brachmann De Lange Syndrome

Brachmann-De Lange Syndrome

Cdls

Bdls

Typus Degenerativus Amstelodamensis
Aplastic Anemia

Aplastic Anemia, Susceptibility To

Anemia Aplastic

Idiopathic Aplastic Anemia

Secondary Aplastic Anemia

Idiopathic Bone Marrow Failure

Aplastic Anemia Idiopathic

AA

Anemia, Aplastic

Aplastic Anemia, Idiopathic

Erythroid Aplasia

Aa - [Aplastic Anaemia]

Haematopoietic Aplasia

Aleukia Haemorrhagica

Anaemia Due To Decreased Red Cell Production

Aplasia Bone Marrow

Aplastic Bone Marrow

Hypoplastic Anaemia Nos

Myeloid Bone Marrow Aplasia

Pancytopenia

Panhaematopenia

Hypoproliferative Anaemia

Medullary Hypoplasia

Red Blood Cells Hypoplastic Anaemia

Panmyelophthisis

Panhemocytopenia

Refractive Hypoproliferative Anaemia

Toxic Anaemia

Toxic Aplastic Anaemia

Aplastic Anaemia Due To Toxic Cause

Idiopathic Aplastic Anaemia Nos
Fanconi Anemia, Complementation Group A

Fanconi Anemia

Fanconi Pancytopenia

Fanconi Anemia Complementation Group A

FANCA

Fa

Fanconi Panmyelopathy

Fanconi'S Anemia

Fanconi Anaemia

Fanconi'S Anaemia

Fanconi Hypoplastic Anemia

Estren-Dameshek Variant Of Fanconi Anemia

Estren-Dameshek Variant Of Fanconi Pancytopenia

Fanconi Anemia Estren-Dameshek Variant

Fanconis Anemia
Seckel Syndrome

Microcephalic Primordial Dwarfism

Bird-Headed Dwarfism

Harper'S Syndrome

Virchow-Seckel Dwarfism

Nanocephalic Dwarfism

Sckl

Seckel-Type Dwarfism
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS11598 RAD18 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris RAD18 VGNC VGNC:45312
Mus musculus RAD18 MGD MGI:1890476
Rattus norvegicus RAD18 RGD RGD:1306993
Macaca mulatta RAD18 VGNC VGNC:76508
Felis catus RAD18 VGNC VGNC:64477
Bos taurus RAD18 VGNC VGNC:33679
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