ORC2 - origin recognition complex subunit 2 Gene

中文名称：起源识别复合亚基 2

种属: Homo sapiens

同用名: ORC2L

关于 ORC2

功能概要

起源识别复合物 (ORC) 是一种高度保守的六亚基蛋白复合物，对于真核细胞中 DNA 复制的启动至关重要。对酵母的研究表明，ORC 与复制起点特异性结合，并作为组装其他起始因子 (如 Cdc6 和 Mcm 蛋白) 的平台。该基因编码的蛋白质是 ORC 复合体的一个亚基。该蛋白质与 ORC3、-4 和 -5 形成核心复合体。它还与 CDC45 和 MCM10 相互作用，这些蛋白质已知对启动 DNA 复制很重要。这种蛋白质已被证明与人体细胞中 Epstein-Barr 病毒的复制起点特异性相关，并且被认为是从病毒复制起点复制 DNA 所必需的。已发现选择性剪接的转录物变体，其中之一是无义介导的 mRNA 衰变候选物。[RefSeq 提供，2010 年 10 月]

The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. This protein forms a core complex with ORC3, -4, and -5. It also interacts with CDC45 and MCM10, which are proteins known to be important for the initiation of DNA replication. This protein has been demonstrated to specifically associate with the origin of replication of Epstein-Barr virus in human cells, and is thought to be required for DNA replication from viral origin of replication. Alternatively spliced transcript variants have been found, one of which is a nonsense-mediated mRNA decay candidate. [provided by RefSeq, Oct 2010]