MCM10 - minichromosome maintenance 10 replication initiation factor Gene

中文名称：微染色体维持 10 复制起始因子

种属: Homo sapiens

同用名: CNA43; DNA43; IMD80; PRO2249

基因 ID: 55388 | 基因类型: protein coding

关于 MCM10

Cytogenetic location: 10p13 Genomic coordinates (GRCh38): 10:13,161,558-13,211,110 (from NCBI)

This gene has 7 transcripts (splice variants), 203 orthologues and is associated with 1 phenotype. Broad expression in bone marrow (RPKM 2.8), lymph node (RPKM 2.2) and 15 other tissues.

功能概要

由该基因编码的蛋白质是高度保守的微型染色体维持蛋白 (MCM) 之一，参与真核基因组复制的启动。由 MCM 蛋白形成的六聚体蛋白复合物是复制前复合物 (pre-RC) 的关键组成部分，它可能参与复制叉的形成和其他 DNA 复制相关蛋白的募集。该蛋白可以与 MCM2 和 MCM6 以及起源识别蛋白 ORC2 相互作用。它以细胞周期依赖性方式通过蛋白水解和磷酸化进行调节。对非洲爪蟾中一种类似蛋白质的研究表明，这种蛋白质在 DNA 复制开始时的染色质结合发生在预 RC 组装之后和原点解旋之前。已经鉴定出编码不同亚型的可变剪接转录物变体。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre-RC) and it may be involved in the formation of replication forks and in the recruitment of Other DNA replication related proteins. This protein can interact with MCM2 and MCM6, as well as with the origin recognition protein ORC2. It is regulated by proteolysis and phosphorylation in a cell cycle-dependent manner. Studies of a similar protein in Xenopus suggest that the chromatin binding of this protein at the onset of DNA replication is after pre-RC assembly and before origin unwinding. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]

MCM10 基因产物(2)

mRNA	Protein	Name
NM_018518.5	NP_060988.3	protein MCM10 homolog isoform 2
NM_182751.3	NP_877428.1	protein MCM10 homolog isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables identical protein binding	IPI IPI: 通过物理相互作用推断	17823614	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	11095689	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in DNA damage response	IMP IMP: 通过突变表型推断	24726359	GOA
involved in DNA replication initiation	IMP IMP: 通过突变表型推断	32865517	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in nucleus	IDA IDA: 通过直接分析推断	11095689	GOA
located in nucleus	IMP IMP: 通过突变表型推断	32865517	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MCM10 蛋白结构

zf-primase

Mcm10

0
200
400
600
800
875 a.a.

蛋白主名

其他名称

protein MCM10 homolog

MCM10 minichromosome maintenance deficient 10

MCM10 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	MCM10	Q7L590	MCM6	Homo sapiens	Q14566	Anti Tag CoIP	35271311
种属内	MCM10	Q7L590	MCM6	Homo sapiens	Q14566	Protein Array	15232106
种属内	MCM10	Q7L590	CDC6	Homo sapiens	Q99741	Protein Array	15232106
种属内	MCM10	Q7L590	CDC45	Homo sapiens	O75419	Protein Array	15232106
种属内	MCM10	Q7L590	CEP72	Homo sapiens	Q9P209	Y2H Array	31515488
种属内	MCM10	Q7L590	CDC7	Homo sapiens	O00311	Protein Array	15232106
种属内	MCM10	Q7L590	CDK6	Homo sapiens	Q00534	Protein Array	15232106
种属内	MCM10	Q7L590	ORC2	Homo sapiens	Q13416	Y2H	11095689
种属内	MCM10	Q7L590	CEP72	Homo sapiens	Q9P209	Y2H Pooling	16189514
种属内	MCM10	Q7L590	CCND3	Homo sapiens	P30281	Protein Array	15232106
种属内	MCM10	Q7L590	MCM10	Homo sapiens	Q7L590	GMS	17823614
种属内	MCM10	Q7L590	CDC5L	Homo sapiens	Q99459	Protein Array	15232106
种属内	MCM10	Q7L590	MCM10	Homo sapiens	Q7L590	EM	17823614
种属内	MCM10	Q7L590	CCND1	Homo sapiens	P24385	Protein Array	15232106
种属内	MCM10	Q7L590	ORC2	Homo sapiens	Q13416	Anti Bait CoIP	11095689

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Immunodeficiency 80 With Or Without Congenital Cardiomyopathy

IMD80	Mcm10 Deficiency
Immunodeficiency 80 With Or Without Cardiomyopathy

Nk Cell Deficiency

Restrictive Cardiomyopathy

Familial Restrictive Cardiomyopathy	Cardiomyopathy, Restrictive
Cardiomyopathy, Constrictive	Primary Restrictive Cardiomyopathy
Rcm	Cardiomyopathy Restrictive

Endometrial Mixed Adenocarcinoma

Baller-Gerold Syndrome

BGS	Craniosynostosis With Radial Defects
Craniosynostosis-Radial Aplasia Syndrome	Craniosynostosis Radial Aplasia Syndrome

Rapadilino Syndrome

Absent Thumbs, Dislocated Joints, Long Face With Narrow Palpebral Fissures, Long Slender Nose, Arched Palate	Radial And Patellar Aplasia
Radial And Patellar Hypoplasia	RAPADILINOS

Ovary Serous Adenocarcinoma

Malignant Ovarian Serous Tumor

Serous Carcinoma Of Ovary

Filippi Syndrome

Scott Craniodigital Syndrome With Mental Retardation	Type 1 Syndactyly-Microcephaly-Intellectual Disability Syndrome
FLPIS	Scott Bryant Graham Syndrome
Craniodigital-Intellectual Disability Syndrome	Scott Craniodigital Syndrome
Scott-Bryant-Graham Syndrome	Syndactyly, Type I, With Microcephaly And Mental Retardation
Syndactyly Type I With Microcephaly And Intellectual Disability	Unusual Facial Appearance, Microcephaly, Growth And Intellectual Disability And Syndactyly
Craniodigital Syndrome With Intellectual Disability	Craniodigital Syndrome-Intellectual Disability Syndrome
Craniodigital Syndrome-Intellectual Disability, Scott Type	Intellectual Disability-Craniodigital Syndrome

Fanconi Anemia, Complementation Group A

Fanconi Anemia	Fanconi Pancytopenia
Fanconi Anemia Complementation Group A	FANCA
Fa	Fanconi Panmyelopathy
Fanconi'S Anemia	Fanconi Anaemia
Fanconi'S Anaemia	Fanconi Hypoplastic Anemia
Estren-Dameshek Variant Of Fanconi Anemia	Estren-Dameshek Variant Of Fanconi Pancytopenia
Fanconi Anemia Estren-Dameshek Variant	Fanconis Anemia

Meier-Gorlin Syndrome 1

Meier-Gorlin Syndrome	Ear, Patella, Short Stature Syndrome
Microtia, Absent Patellae, Micrognathia Syndrome	MGORS1
Eps	Ear-Patella-Short Stature Syndrome
Ear Patella Short Stature Syndrome	Microtia Absent Patellae Micrognathia Syndrome
Meier-Gorlin Syndrome, Type 1

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS08233	MCM10 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	MCM10	VGNC	VGNC:31307
Macaca mulatta	MCM10	VGNC	VGNC:74528
Mus musculus	MCM10	MGD	MGI:1917274
Felis catus	MCM10	VGNC	VGNC:63414
Rattus norvegicus	MCM10	RGD	RGD:1311330
Canis familiaris	MCM10	VGNC	VGNC:43080

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

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沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

MCM10 - minichromosome maintenance 10 replication initiation factor Gene

关于 MCM10

功能概要

MCM10 基因产物(2)

MCM10 蛋白结构

MCM10 蛋白互作信息

关联疾病

直系同源

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MCM10 - minichromosome maintenance 10 replication initiation factor Gene

关于 MCM10

功能概要

MCM10 基因产物(2)

MCM10 蛋白结构

MCM10 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

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C

F

G

H

J

L

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Q

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