1. Gene
  2. CDK6 - cyclin dependent kinase 6 Gene

CDK6 - cyclin dependent kinase 6 Gene

中文名称:细胞周期蛋白依赖性激酶 6

种属: Homo sapiens

同用名: MCPH12; PLSTIRE

基因 ID: 1021 | 基因类型: protein coding

关于 CDK6

Cytogenetic location: 7q21.2 Genomic coordinates (GRCh38): 7:92,604,921-92,836,573 (from NCBI)

This gene has 5 transcripts (splice variants), 199 orthologues, 26 paralogues and is associated with 66 phenotypes. Ubiquitous expression in placenta (RPKM 9.3), bone marrow (RPKM 7.6) and 25 other tissues.

功能概要

该基因编码的蛋白质是丝氨酸/苏氨酸蛋白激酶 CMGC 家族的成员。这种激酶是蛋白激酶复合物的催化亚基,对细胞周期 G1 期进程和 G1/S 转换很重要。这种激酶的活性首先出现在 G1 中期,受调节亚基控制,包括 D 型细胞周期蛋白和 CDK 抑制剂 INK4 家族成员。这种激酶以及 CDK4 已被证明可以磷酸化,从而调节肿瘤抑制蛋白 Rb 的活性。已在多种人类癌症中观察到该基因的表达改变。该基因的突变导致细胞增殖减少,细胞运动性和极性受损,并且已在原发性小头畸形患者中发现。[RefSeq 提供,2017 年 8 月]

The protein encoded by this gene is a member of the CMGC family of serine/threonine protein kinases. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. Altered expression of this gene has been observed in multiple human cancers. A mutation in this gene resulting in reduced cell proliferation, and impaired cell motility and polarity, and has been identified in patients with primary microcephaly. [provided by RefSeq, Aug 2017]

CDK6 基因产物(3)

mRNA Protein Name
NM_001145306.2 NP_001138778.1 cyclin-dependent kinase 6
NM_001259.8 NP_001250.1 cyclin-dependent kinase 6
XM_047419716.1 XP_047275672.1 cyclin-dependent kinase 6 isoform X1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ATP binding IDA
IDA: 通过直接分析推断
9751050 GOA
enables FBXO family protein binding IPI
IPI: 通过物理相互作用推断
18495667 GOA
enables cyclin binding IPI
IPI: 通过物理相互作用推断
8114739 GOA
enables cyclin-dependent protein serine/threonine kinase activity IDA
IDA: 通过直接分析推断
8114739 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
8001816 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in G1/S transition of mitotic cell cycle IDA
IDA: 通过直接分析推断
8114739 GOA
involved in cell dedifferentiation IMP
IMP: 通过突变表型推断
12861051 GOA
involved in gliogenesis IMP
IMP: 通过突变表型推断
12861051 GOA
involved in negative regulation of cell cycle IDA
IDA: 通过直接分析推断
14985467 GOA
involved in negative regulation of cellular senescence IDA
IDA: 通过直接分析推断
17420273 GOA
involved in negative regulation of epithelial cell proliferation IMP
IMP: 通过突变表型推断
14985467 GOA
involved in negative regulation of monocyte differentiation IDA
IDA: 通过直接分析推断
26542173 GOA
involved in negative regulation of myeloid cell differentiation IDA
IDA: 通过直接分析推断
17431401 GOA
involved in negative regulation of osteoblast differentiation IDA
IDA: 通过直接分析推断
15254224 GOA
involved in positive regulation of cell-matrix adhesion IDA
IDA: 通过直接分析推断
10205165 GOA
involved in positive regulation of fibroblast proliferation IMP
IMP: 通过突变表型推断
17420273 GOA
involved in protein phosphorylation IDA
IDA: 通过直接分析推断
8114739 GOA
involved in regulation of erythrocyte differentiation IMP
IMP: 通过突变表型推断
12833137 GOA
involved in regulation of gene expression IDA
IDA: 通过直接分析推断
15254224 GOA
involved in regulation of gene expression IMP
IMP: 通过突变表型推断
17420273 GOA
involved in response to virus IEP
IEP: 通过表达模式推断
16548883 GOA
involved in type B pancreatic cell development IDA
IDA: 通过直接分析推断
20668294 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in centrosome IDA
IDA: 通过直接分析推断
23918663 GOA
part of cyclin D1-CDK6 complex IPI
IPI: 通过物理相互作用推断
15232106 GOA
part of cyclin D3-CDK6 complex IPI
IPI: 通过物理相互作用推断
8114739 GOA
part of cyclin-dependent protein kinase holoenzyme complex IDA
IDA: 通过直接分析推断
17420273 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
14985467 GOA
located in nucleus IDA
IDA: 通过直接分析推断
14985467 GOA
located in ruffle IDA
IDA: 通过直接分析推断
10205165 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

CDK6 蛋白结构

Pkinase

Pkinase: Protein kinase domain (13 - 300)

  • 0
  • 100
  • 200
  • 300
  • 326 a.a.
蛋白主名 其他名称

cyclin-dependent kinase 6

cell division protein kinase 6

serine/threonine-protein kinase PLSTIRE

CDK6 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra CDK6 Q00534 CCNI Homo sapiens Q14094
Validated Y2H
32296183
Intra CDK6 Q00534 APOBEC1 Homo sapiens P41238
Y2H Array
32296183
Intra CDK6 Q00534 APOBEC1 Homo sapiens P41238
Y2H Prey Pooling
32296183
Intra CDK6 Q00534 OTP Homo sapiens Q5XKR4
Validated Y2H
32296183
Intra CDK6 Q00534 OTP Homo sapiens Q5XKR4
Y2H Array
32296183
Intra CDK6 Q00534 OTP Homo sapiens Q5XKR4
Y2H Prey Pooling
32296183
Intra CDK6 Q00534 TRIM15 Homo sapiens Q9C019
Y2H Prey Pooling
32296183
Intra CDK6 Q00534 TRIM15 Homo sapiens Q9C019
Validated Y2H
32296183
Intra CDK6 Q00534 TRIM15 Homo sapiens Q9C019
Y2H Array
32296183
Intra CDK6 Q00534 CDC37 Homo sapiens Q16543
CoIP
9150368
Intra CDK6 Q00534 CDC37 Homo sapiens Q16543
Lumier
25036637
Intra CDK6 Q00534 CDC37 Homo sapiens Q16543
Y2H
9150368
Intra CDK6 Q00534 HSP90AB1 Homo sapiens P08238
Anti Tag CoIP
33961781
Intra CDK6 Q00534 CCND1 Homo sapiens P24385
Anti Bait CoIP
17517622
Intra CDK6 Q00534 CCND1 Homo sapiens P24385
Anti Bait CoIP
24855949
Intra CDK6 Q00534 CCND1 Homo sapiens P24385
Anti Tag CoIP
33961781
Intra CDK6 Q00534 CCND1 Homo sapiens P24385
Protein Array
15232106
Intra CDK6 Q00534 CCND3 Homo sapiens P30281
Validated Y2H
27107012
Intra CDK6 Q00534 CCND3 Homo sapiens P30281
Y2H Array
31515488
Intra CDK6 Q00534 CCND3 Homo sapiens P30281
Y2H Prey Pooling
25416956
Intra CDK6 Q00534 CCND3 Homo sapiens P30281
BFG-2H
27107012
Intra CDK6 Q00534 CCND3 Homo sapiens P30281
Validated Y2H
25416956
Intra CDK6 Q00534 CCND3 Homo sapiens P30281
TAP
23602568
Intra CDK6 Q00534 CCND3 Homo sapiens P30281
Y2H Array
25416956
Intra CDK6 Q00534 CCND3 Homo sapiens P30281
MAPPIT
25416956
Intra CDK6 Q00534 CCND3 Homo sapiens P30281
Protein Array
15232106
Intra CDK6 Q00534 CCND3 Homo sapiens P30281
SLC
27107012
Intra CDK6 Q00534 CCND3 Homo sapiens P30281
Anti Bait CoIP
17517622
Intra CDK6 Q00534 CCND3 Homo sapiens P30281
Y2H
21516116
Intra CDK6 Q00534 CDKN2A Homo sapiens P42771
Anti Bait CoIP
17909018
Intra CDK6 Q00534 CDKN2A Homo sapiens P42771
Anti Bait CoIP
24855949
Intra CDK6 Q00534 CDKN2A Homo sapiens P42771
TAP
23602568
Intra CDK6 Q00534 CDKN2A Homo sapiens P42771
Anti Tag CoIP
33961781
Intra CDK6 Q00534 CDKN2A Homo sapiens P42771
Anti Tag CoIP
28514442
Intra CDK6 Q00534 CDKN2A Homo sapiens P42771
Pull Down
32707033
Intra CDK6 Q00534 CDKN2A Homo sapiens P42771
Protein Array
15232106
Intra CDK6 Q00534 CDKN2A Homo sapiens P42771
Pull Down
24855949
Intra CDK6 Q00534 CDKN1A Homo sapiens P38936
Anti Tag CoIP
33961781
Intra CDK6 Q00534 CDKN1A Homo sapiens P38936
Anti Tag CoIP
28514442
Intra CDK6 Q00534 CDKN2B Homo sapiens P42772
Anti Tag CoIP
33961781
Intra CDK6 Q00534 CDKN2B Homo sapiens P42772
TAP
23602568
Intra CDK6 Q00534 CDKN2B Homo sapiens P42772
Y2H Array
32296183
Intra CDK6 Q00534 CDKN2B Homo sapiens P42772
Anti Tag CoIP
28514442
Intra CDK6 Q00534 CDKN2B Homo sapiens P42772
Pull Down
32707033
Intra CDK6 Q00534 CDKN2B Homo sapiens P42772
Y2H Prey Pooling
32296183
Intra CDK6 Q00534 CDKN2C Homo sapiens P42773
Validated Y2H
27107012
Intra CDK6 Q00534 CDKN2C Homo sapiens P42773
Y2H Array
31515488
Intra CDK6 Q00534 CDKN2C Homo sapiens P42773
Y2H Array
25502805
Intra CDK6 Q00534 CDKN2C Homo sapiens P42773
Anti Tag CoIP
33961781
Intra CDK6 Q00534 CDKN2C Homo sapiens P42773
Validated Y2H
25416956
Intra CDK6 Q00534 CDKN2C Homo sapiens P42773
TAP
23602568
Intra CDK6 Q00534 CDKN2C Homo sapiens P42773
Y2H Array
25416956
Intra CDK6 Q00534 CDKN2C Homo sapiens P42773
Y2H Array
32296183
Intra CDK6 Q00534 CDKN2C Homo sapiens P42773
Pull Down
32707033
Intra CDK6 Q00534 CDKN2C Homo sapiens P42773
Y2H Prey Pooling
25416956
Intra CDK6 Q00534 CDKN2C Homo sapiens P42773
Pull Down
8840966
Intra CDK6 Q00534 CDKN2C Homo sapiens P42773
Y2H Prey Pooling
32296183
Intra CDK6 Q00534 CDKN2C Homo sapiens P42773
Anti Bait CoIP
18394558
Intra CDK6 Q00534 CCNH Homo sapiens P51946
Y2H Array
32296183
Intra CDK6 Q00534 CCNH Homo sapiens P51946
Y2H Prey Pooling
32296183
Intra CDK6 Q00534 CDKN2D Homo sapiens P55273
Y2H Prey Pooling
32296183
Intra CDK6 Q00534 CDKN2D Homo sapiens P55273
Validated Y2H
27107012
Intra CDK6 Q00534 CDKN2D Homo sapiens P55273
BFG-2H
27107012
Intra CDK6 Q00534 CDKN2D Homo sapiens P55273
Y2H Array
32296183
Intra CDK6 Q00534 CDKN2D Homo sapiens P55273
Anti Tag CoIP
33961781
Intra CDK6 Q00534 CDKN2D Homo sapiens P55273
TAP
23602568
Intra CDK6 Q00534 CDKN2D Homo sapiens P55273
Anti Tag CoIP
28514442
Intra CDK6 Q00534 CDKN2D Homo sapiens P55273
Y2H Array
31515488
Intra CDK6 Q00534 CDKN2D Homo sapiens P55273
Y2H Prey Pooling
25416956
Intra CDK6 Q00534 CDKN2D Homo sapiens P55273
SLC
27107012
Intra CDK6 Q00534 RUNX1 Homo sapiens Q01196
Anti Bait CoIP
17431401
Intra CDK6 Q00534 RUNX1 Homo sapiens Q01196
Anti Tag CoIP
17431401
Intra CDK6 Q00534 RUNX1 Homo sapiens Q01196
PLA
25241761
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Kaposi Sarcoma

Kaposi'S Sarcoma

Kaposi Sarcoma, Susceptibility To

Kaposi'S Sarcoma Of Lung

Kaposi'S Sarcoma Of Palate

Kaposi'S Sarcoma Of Soft Tissue

Multiple Idiopathic Pigmented Hemangiosarcoma

Multiple Idiopathic Pigmented Hemangiosarcoma, Susceptibility To

African Lymphadenopathic Kaposi'S Sarcoma

Anal Kaposi'S Sarcoma

Cardiac Kaposi'S Sarcoma

Central Nervous System Kaposi'S Sarcoma

Conjunctival Kaposi'S Sarcoma

Corneal Kaposi'S Sarcoma

Cutaneous Kaposi'S Sarcoma

Esophageal Kaposi'S Sarcoma

Gallbladder Kaposi'S Sarcoma

Gastric Kaposi'S Sarcoma

Intestinal Kaposi'S Sarcoma

Kaposi'S Sarcoma Of Anus

Kaposi'S Sarcoma Of Central Nervous System

Kaposi'S Sarcoma Of Conjunctiva

Kaposi'S Sarcoma Of Cornea

Kaposi'S Sarcoma Of Esophagus

Kaposi'S Sarcoma Of Gastrointestinal Sites

Kaposi'S Sarcoma Of Heart

Kaposi'S Sarcoma Of Lymph Nodes

Kaposi'S Sarcoma Of Penis

Kaposi'S Sarcoma Of Skin

Kaposi'S Sarcoma Of Soft Tissues

Kaposi'S Sarcoma Of The Cns

Kaposi'S Sarcoma Of The Gallbladder

Kaposi'S Sarcoma Of The Prostate

Kaposi'S Sarcoma, Lung

Kaposi'S Sarcoma, Skin

Kaposi'S Sarcoma-Associated Herpesvirus

Lymph Node Kaposi'S Sarcoma

Lymphadenopathic Kaposi'S Sarcoma

Palate Kaposi'S Sarcoma

Penis Kaposi'S Sarcoma

Prostate Kaposi'S Sarcoma

Pulmonary Kaposi'S Sarcoma

Soft Tissue Kaposi'S Sarcoma

Hhv8

Human Herpesvirus 8

Kshv

Kaposi Sarcoma Herpesvirus

Mediterranean Kaposi Sarcoma

Non Aids Related Kaposi Sarcoma

Sarcoma, Kaposi

Sarcoma, Kaposi, Susceptibility To

Non-Aids-Related Kaposi Sarcoma

Angiolymphoid Hyperplasia

Angiofollicular Ganglionic Hyperplasia

Multi-Centric Castleman'S Disease

Leukemia, Acute Myeloid

Acute Myeloid Leukemia

Leukemia, Acute Myelogenous

Acute Myelogenous Leukemia

AML

Leukemia, Acute Myeloid, Susceptibility To

Acute Myeloblastic Leukemia

Leukemia, Acute Myeloid, Reduced Survival In, Somatic

Acute Myeloid Leukaemia

Leukemia, Myelocytic, Acute

Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome

Secondary Aml

Acute Myelocytic Leukemia

Leukemia, Myeloid, Acute

Acute Myeloid Leukemia, Somatic

Leukemia, Acute Myeloid, Somatic

Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic

Acute Myeloblastic Leukaemia

Acute Myelogenous Leukaemia

Aml - Acute Myeloid Leukemia

Acute Myeloid Leukemia With Cebpa Somatic Mutations

Aml With Cebpa Somatic Mutations

Inherited Acute Myeloid Leukemia

Familial Aml

Inherited Aml

Pure Familial Aml

Pure Familial Acute Myeloid Leukemia

Secondary Acute Myeloid Leukemia

Therapy-Related Aml And Myelodysplastic Syndrome

Acute Myeloid Leukemia, Secondary

Acute Non-Lymphoblastic Leukemia

Acute Non-Lymphocytic Leukemia

Acute Biphenotypic Leukemia

Acute Undifferentiated Leukemia

Acute Myeloblastic Leukaemia With Multilineage Dysplasia

Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission

Acute Myeloid Leukaemia With Myelodysplasia-Related Features

Esophageal Cancer

Esophageal Carcinoma

Carcinoma Of Esophagus

Esophageal Squamous Cell Carcinoma, Somatic

Esophageal Carcinoma, Somatic

Esophagus Cancer

Gastric Cardia Adenocarcinoma

Esophageal Neoplasms

Esophageal Cancer, Somatic

Cancer Of Esophagus

Cancer Of Oesophagus

Carcinoma Of Oesophagus

Ca Lower Third Oesophagus

Ca Middle Third Oesophagus

Malignant Neoplasm Of Distal Third Of Esophagus

Malignant Neoplasm Of Lower Third Of Oesophagus

Malignant Neoplasm Of Middle Third Of Oesophagus

Malignant Neoplasm Of Proximal Third Of Esophagus

Malignant Neoplasm Of Upper Third Esophagus

Malignant Tumor Of Abdominal Esophagus

Malignant Tumor Of Distal Third Of Esophagus

Malignant Tumor Of Proximal Third Of Esophagus

Malignant Tumor Of The Middle Third Of The Esophagus

ESCR

Aerodigestive Tract Cancer

Escc

Esophageal Squamous Cell Carcinoma

Cancer, Esophageal

Malignant Neoplasm Of Esophagus

Squamous Cell Carcinoma Of Esophagus

Malignant Neoplasm Of Middle Third Of Esophagus

Microcephaly

Microencephaly

Microcephalus

Microcephalic

Nanocephaly

Congenital Microcephaly

Brain Hypoplasia

Brain Nondevelopment

Cephalic Hypoplasia

Undeveloped Cerebrum

Undeveloped Brain

Micrencephalon

Micrencephaly

Microcephaly 12, Primary, Autosomal Recessive

MCPH12

Primary Autosomal Recessive Microcephaly 12

Microcephaly, Type 12, Primary, Autosomal Recessive

Ocular Cancer

Eye Carcinoma

Eye Neoplasm

Eye Cancer

Eye Neoplasms

Malignant Eye Neoplasm

Neoplasm Of Eye

Neoplasm Of Eye Proper

Ocular Tumor

Carcinoma Of Eye

Ocular Carcinoma

Malignant Tumor Of Eye

Thrombocytopenia

Low Platelet Count

Low Platelets

Decreased Platelets

Platelet Dysfunction Nos

Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon

Hepatocellular Carcinoma

Liver Cancer

Primary Liver Cancer

HCC

Hepatoma

Malignant Neoplasm Of Liver

Liver Neoplasms

Cancer, Hepatocellular

Liver Cell Carcinoma

Lcc

Hepatoblastoma, Somatic

Hepatic Cancer

Primary Malignant Neoplasm Of Liver

Rare Tumor Of Liver And Intrahepatic Biliary Tract

Hepatocellular Carcinoma, Somatic

Hepatocellular Carcinoma, Childhood Type, Somatic

Hepatocellular Cancer, Somatic

Ca Liver - Primary

Hepatic Neoplasm

Malignant Hepato-Biliary Neoplasm

Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

Malignant Neoplasm Of Liver, Primary

Malignant Tumor Of Liver

Neoplasm Of Liver

Non-Resectable Primary Hepatic Malignant Neoplasm

Resectable Malignant Neoplasm Of Liver

Resectable Malignant Neoplasm Of The Liver

Primary Liver Carcinoma

Primary Malignant Liver Neoplasm

Primary Cancer Of Liver

Primary Tumor Of The Liver

Rare Tumor Of Liver And Ibt

Hepatocellular Cancer

Neoplasm Of The Liver

Hepatomas

Liver Neoplasm

Liver Carcinoma

Liver And Intrahepatic Biliary Tract Carcinoma

Malignant Hepatobiliary Neoplasm

Adult Primary Hepatocellular Carcinoma

Hepatoblastoma

Carcinoma Of Liver

Malignant Liver Tumour

Malignant Hepatic Tumour

Adenocarcinoma

Adenocarcinomas

Adenoacanthoma Of Unspecified Site

Adenocarcinoid Of Unspecified Site

Adenocarcinoid Tumour Of Unspecified Site

Adenocarcinoma And Carcinoid Combined Of Unspecified Site

Adenocarcinoma Nos

Glioblastoma

Glioblastoma Multiforme

Gbm

Adult Glioblastoma Multiforme

Grade Iv Adult Astrocytic Tumor

Primary Glioblastoma Multiforme

Spongioblastoma Multiforme

Adult Glioblastoma

Primary Glioblastoma

Rhabdomyosarcoma
Non-Syndromic X-Linked Intellectual Disability

X-Linked Non-Syndromic Intellectual Disability

Non-Specific X-Linked Mental Retardation

X-Linked Non-Specific Intellectual Disability

Squamous Cell Carcinoma, Head And Neck

Squamous Cell Carcinoma Of The Head And Neck

HNSCC

Head And Neck Squamous Cell Carcinoma

Head And Neck Cancer

Squamous Cell Carcinoma Of Lip

Squamous Cell Carcinoma, Head And Neck, Somatic

Carcinoma Of The Head And Neck

Squamous Cell Carcinomas Of Head And Neck

Scchn

Squamous Cell Carcinoma Of The Hypopharynx

Squamous Cell Carcinoma Of The Oropharynx

Squamous Cell Carcinoma Of Salivary Glands

Squamous Cell Carcinoma Of The Nasal Cavity And Paranasal Sinuses

Squamous Cell Carcinoma Of The Nasal Cavity And Sinuses

Squamous Cell Carcinoma Of The Oral Cavity

Squamous Cell Carcinoma Of The Lip

Carcinoma, Squamous Cell Of Head And Neck

Lip Squamous Cell Carcinoma

Cancer, Head/Neck

Carcinoma, Squamous Cell, Head And Neck

Salivary Gland Squamous Cell Carcinoma

Cancer Of Head And Neck

Squamous Cell Carcinoma Of Oropharynx Nos

Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer

Squamous Cell Carcinoma

Epidermoid Carcinoma

Squamous Cell Cancer

Carcinoma, Squamous Cell

Malignant Squamous Cell Tumor

Squamous Carcinoma

Squamous Cell Epithelioma

Squamous Cell Skin Cancer

Carcinoma Squamous Cell

Neoplasms, Squamous Cell

Squamous Cell Carcinoma - Category

Malignant Squamous Cell Neoplasm

Squamous Cell Carcinoma Of Skin

T-Cell Acute Lymphoblastic Leukemia

T-Cell Leukemia

Acute T Cell Leukemia

Precursor T Lymphoblastic Leukemia

Precursor T-Lymphoblastic Lymphoma/Leukemia

T Acute Lymphoblastic Leukemia

T-Cell Acute Lymphocytic Leukaemia

T-Cell Lymphoblastic Leukemia/Lymphoma

Leukemia T-Cell

Leukemia, T-Cell

Leukemia, Acute, Lymphoblastic, T-Cell

Leukemia, T-Cell Acute Lymphoblastic

Leukemia, Acute T-Cell

Precursor T-Cell Lymphoblastic Leukemia-Lymphoma

Precursor T-Cell Lymphoblastic Lymphoma

Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma

Leukemia, Acute Lymphoblastic

Acute Lymphoblastic Leukemia

ALL

Acute Lymphocytic Leukemia

Leukemia, Acute Lymphocytic, Susceptibility To, 1

Acute Lymphoblastic Leukaemia

Precursor Lymphoblastic Lymphoma/Leukemia

Precursor Lymphoid Neoplasm

Leukemia, Acute Lymphoblastic, Susceptibility To

B-Cell Acute Lymphoblastic Leukemia

Leukemia, Acute Lymphocytic 1

Acute Lymphocytic Leukaemia

Acute Lymphoblastic Leukemia/Lymphoma

All1

Childhood Acute Lymphoblastic Leukemia

Leukemia Acute Lymphoblastic 1

Leukemia Acute Lymphoblastic B-Hyperdiploid

Leukemia Acute Lymphocytic

Leukemia Acute Lymphocytic 1

Leukemia B-Cell Acute Lymphoblastic

Leukemia T-Cell Acute Lymphoblastic

Leukemia, Acute Lymphoblastic, 3

ALL3

Lymphoblastic Leukemia Acute

Leukemia, Acute, Lymphoblastic

Precursor Cell Lymphoblastic Leukemia Lymphoma

Leukemia, Lymphocytic, Acute, L1

Leukemia, Acute Lymphoblastic, Susceptibility To, 3

Ovarian Cancer

Ovarian Carcinoma

Ovarian Neoplasm

Malignant Tumour Of Ovary

Epithelial Ovarian Cancer

Neoplasm Of Ovary

Ovarian Neoplasms

Ovarian Cancers

Malignant Neoplasm Of Ovary

Primary Malignant Neoplasm Of Ovary

Ovarian Cancer, Somatic

Malignant Ovarian Tumor

Ovary Neoplasm

Primary Ovarian Cancer

Tumor Of The Ovary

Cancer Of The Ovary

Malignant Neoplasm Of The Ovary

Malignant Tumor Of The Ovary

Ovarian Malignant Tumor

OC

Ovarian Carcinomas

Cancer, Ovarian

Cancer Of Ovary

Ovary Cancer

Ca Ovary

Pancreatic Cancer

Pancreatic Carcinoma

Familial Pancreatic Carcinoma

Pancreatic Neoplasm

Carcinoma Of Pancreas

Pancreatic Carcinoma, Familial

Malignant Neoplasm Of Pancreas

Pancreatic Acinar Carcinoma

Pancreatic Tumor

Familial Pancreatic Cancer

Neoplasm Of The Pancreas

Pancreatic Carcinoma, Somatic

Pancreatic Cancer, Somatic

Ca Body Of Pancreas

Ca Head Of Pancreas

Ca Tail Of Pancreas

Malignant Neoplasm Of Body Of Pancreas

Malignant Neoplasm Of Head Of Pancreas

Malignant Neoplasm Of Tail Of Pancreas

Pancreas Neoplasm

Exocrine Cancer

Exocrine Pancreas Carcinoma

Hereditary Pancreatic Cancer

Hereditary Pancreatic Carcinoma

PNCA

Cancer Of The Pancreas

Pancreatic Cancer, Susceptibility To

Carcinoma Of Head Of Pancreas

Pancreatic Neoplasms

Pancreatic Tumors

Cancer, Pancreatic

Cancer Of Pancreas

Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Primary Microcephaly

True Microcephaly

Microcephaly, Primary

Rheumatoid Arthritis

RA

Arthritis, Rheumatoid

Rheumatoid Arthritis, Susceptibility To

Arthritis Or Polyarthritis, Rheumatic

Atrophic Arthritis

Rheumatism Arthritis

Rheumatoid Polyarthritis

Dedifferentiated Liposarcoma

Ddls

Liposarcoma Dedifferentiated

Liposarcoma, Dedifferentiated

Retinal Cancer

Malignant Neoplasm Of Retina

Retinal Neoplasms

Malignant Retinal Neoplasm

Malignant Tumor Of Retina

Neoplasm Of Retina

Retinal Tumor

Retinal Neoplasm

Cancer Of The Retina

Malignant Retinal Tumour

Malignant Tumour Of Retina

Primary Malignant Neoplasm Of Retina

Sarcoma

Connective And Soft Tissue Neoplasm

Tumor Of Soft Tissue And Skeleton

Sarcomas

Sarcoma - Category

Mantle Cell Lymphoma

Lymphoma, Mantle Cell

Lcm

Mcl

Mantle Zone Lymphoma

Lymphoma Mantle-Cell

Lymphoma, Mantle-Cell

Malignant Lymphoma, Lymphocytic, Intermediate Differentiation, Diffuse

Malignant Lymphoma - Lymphocytic, Intermediate Differentiation

Diffuse Small Cleaved-Cell Lymphoma

Diffuse Small Cleaved Cell Malignant Lymphoma

Small Cleaved Cell Non-Hodgkin Lymphoma

Diffuse Non-Hodgkin Small Cleaved Cell Lymphoma

Malignant Lymphomatous Polyposis

Malignant Small Cell, Noncleaved, Diffuse Lymphoma

Malignant Undifferentiated Cell, Non-Burkitt Lymphoma

Cleaved Cell Lymphoma

Small Cell Mantle Cell Lymphoma

Small Cleaved Cell Malignant Lymphoma

Lymphoma

Lymphoid Cancer

Lymphomas

Lymphoid Cancers

Lymphoid Neoplasm

Lymphoma Nos

Nhl - [Non-Hodgkin Lymphoma]

Non-Hodgkin Lymphoma

Non-Hodgkin Lymphoma, Nos

Non-Hodgkin Malignant Lymphoma Nos

Sensory System Disease
Breast Cancer

Breast Carcinoma

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Male Breast Cancer

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation

Lymphoma, Non-Hodgkin, Familial

Non-Hodgkin Lymphoma

Lymphoma, Non-Hodgkin

NHL

Lymphoma, Non-Hodgkin, Somatic

Lymphoma, Follicular, Somatic

Familial Non-Hodgkin Lymphoma

Lymphoma Non-Hodgkins

Follicular Lymphoma, Somatic

Lymphosarcoma

Non-Hodgkins Lymphoma

Endometrial Cancer

Endometrial Carcinoma

Endometrial Neoplasm

Malignant Neoplasm Of Endometrium

Endometrioid Carcinoma

Endometrial Neoplasms

Carcinoma, Endometrioid

Endometrial Cancer, Familial

Endometrial Carcinoma, Somatic

Endometrial Cancer, Susceptibility To

Endometrial Ca

Malignant Endometrial Neoplasm

Neoplasm Of Endometrium

Primary Malignant Neoplasm Of Endometrium

Tumor Of Endometrium

Carcinoma Of The Endometrium

Endometrioid Carcinoma Of Female Reproductive System

ENDMC

Carcinoma Endometrioid

Endometrial Cancers

Cancer, Endometrial

Uterine Corpus Cancer

Glioma
Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Protection Against

Lung Cancer, Susceptibility To

Adenocarcinoma Of Lung, Somatic

Nonsmall Cell Lung Cancer

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma

Retinoblastoma

RB

Trilateral Retinoblastoma

RB1

Retinoblastoma, Trilateral

Neuroblastoma Of Retina

Rb - Retinoblastoma

Eye Cancer, Retinoblastoma

Retinal Cancer

Retinal Tumor

Glioma, Retinal

Non-Hereditary Retinoblastoma

Childhood Cancer Retinoblastoma

Malignant Neoplasm Of Retina

Retinal Neoplasms

Eye Disease

Eye Diseases

Abnormality Of The Eye

Toxoplasma Oculopathy

Retinitis Pigmentosa

RP

Rod-Cone Dystrophy

Autosomal Recessive Retinitis Pigmentosa

Non-Syndromic Retinitis Pigmentosa

Pericentral Pigmentary Retinopathy

Pigmentary Retinopathy

Tapetoretinal Degeneration

Rcd

Retinitis Pigmentosa Autosomal Recessive

ARRP

Retinitis Pigmentosa, Autosomal Recessive

Retinitis Pigmentosa 1

Primary Autosomal Recessive Microcephaly

Autosomal Recessive Primary Microcephaly

Mcph

True Microcephaly

Microcephalia Vera

Microcephaly Vera

Microcephaly Primary Hereditary

Microcephaly, Primary, Autosomal Recessive

Primary Microcephaly

Retinal Disease

Retinal Diseases

Retinal Disorder

Retinal Disorders

Melanoma

Malignant Melanoma

Cutaneous Melanoma

Naevocarcinoma

Malignant Melanomas

Nervous System Disease

Abnormality Of The Nervous System

Nervous System Diseases

Nervous System Disorder

Robinow Syndrome, Autosomal Dominant 3

Autosomal Dominant Robinow Syndrome 3

DRS3

Robinow, Autosomal Dominant Syndrome, Type 3

Neuroblastoma

Nb

Neuroblastoma, Susceptibility To

Neuroblastomas

Central Neuroblastoma

Medulloblastoma

MDB

Cpnet

Localized Primitive Neuroectodermal Tumor

Classic Medulloblastoma

Desmoplastic/Nodular Medulloblastoma

Medulloblastoma With Extensive Nodularity

Desmoplastic Medulloblastoma

Medulloblastoma, Somatic

Medulloblastoma, Desmoplastic

Brain Medulloblastoma

Cns Pnet

Infratentorial Primitive Neuroectodermal Tumor

Mben

Medulloblastoma Desmoplastic

Neuroectodermal Tumors, Primitive

Medulloblastomas

Medulloblastoma, With Extensive Nodularity

Medulloblastoma Of Unspecified Site

Medullomyoblastoma Of Unspecified Site

Prostate Signet Ring Cell Adenocarcinoma

Prostate Signet Ring Cell Carcinoma

Signet Ring Cell Carcinoma Of Prostate

Acinar Prostate Adenocarcinoma, Signet Ring Variant

Melanoma, Cutaneous Malignant 1

Familial Melanoma

Melanoma, Cutaneous Malignant, Susceptibility To, 1

CMM1

Melanoma, Cutaneous Malignant

Cmm

Melanoma, Malignant

Familial Atypical Mole-Malignant Melanoma Syndrome

Fammm

Melanoma, Familial

Mlm

Dysplastic Nevus Syndrome, Hereditary

Dns

B-K Mole Syndrome

Melanoma, Cutaneous Malignant, 1

Malignant Melanoma, Cutaneous

Melanoma, Cutaneous, Malignant, Susceptibility To, Type 1

Dysplastic Nevus Syndrome

Cutaneous Melanoma

Familial Atypical Mole Melanoma Syndrome

Hereditary Melanoma

Liposarcoma

Lipomatous Cancer

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus CDK6 RGD RGD:621121
Felis catus CDK6 VGNC VGNC:102025
Macaca mulatta CDK6 VGNC VGNC:70983
Mus musculus CDK6 MGD MGI:1277162
Bos taurus CDK6 VGNC VGNC:27133
Canis familiaris CDK6 VGNC VGNC:54756
Others CDK6 NCBI