CDK2/4/6-IN-1 

CDK2/4/6-IN-1(example 29) is a CDK2/4/6 inhibitor with IC₅₀ values of 2.5, 23.7 and 44.3 nM for CDK2, CDK4 and CDK6, respectively. CDK2/4/6-IN-1 can be used in cancer research^[1]. CDK2/4/6-IN-1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

CDK2/4/6-IN-1(example 29) (0-600 nM, 24 h) inhibits the proliferation of OVCAR3 and MCF7 cells with the IC₅₀ values of 14.6 and 117.8 nM, respectively^[1].
CDK2/4/6-IN-1(example 29) (0-600 nM, 24 h) inhibits phosphorylation of Rb protein in OVCAR3 and MCF7 cells with the IC₅₀ values of 18 and 581 nM, respectively^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CDK2/4/6-IN-1(example 29) (25 mg/kg or 50 mg/kg, once a day, orally) has a significant inhibitory effect on tumor growth^[1].
The pharmacokinetic parameters of example 29 in BALB/c mice (10 mg/kg, p.o.)

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

438.50

C₂₂H₂₂N₄O₄S

2803837-13-8

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. ZHANG YAN, et al. Cdk2/4/6 inhibitor, preparation method therefor, and application thereof. WO2022152259 A1.