1. PROTAC Cell Cycle/DNA Damage
  2. Ligands for Target Protein for PROTAC CDK
  3. Abemaciclib metabolite M18

Abemaciclib metabolite M18  (Synonyms: LSN3106729)

目录号: HY-126534
产品使用指南

Abemaciclib metabolite M18 (LSN3106729),Abemaciclib (HY-16297A) 的代谢物,是一种具有抗肿瘤活性的 CDK 抑制剂。Abemaciclib metabolite M18 和 CRBN 配体可用于设计 PROTAC CDK4/6 降解剂。

在相同的摩尔浓度下,化合物盐形式与游离形式有相同的生物活性,但盐形式 Abemaciclib metabolite M18 hydrochloride 通常具有更好的水溶性和稳定性。

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Abemaciclib metabolite M18 Chemical Structure

Abemaciclib metabolite M18 Chemical Structure

CAS No. : 2704316-81-2

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Abemaciclib metabolite M18 的其他形式现货产品:

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Other Forms of Abemaciclib metabolite M18:

MCE 顾客使用本产品发表的 1 篇科研文献

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Abemaciclib metabolite M18 (LSN3106729), the metabolite of Abemaciclib (HY-16297A), is a CDK inhibitor with antitumor activity. Abemaciclib metabolite M18 and a CRBN ligand have been used to design PROTAC CDK4/6 degrader[1][2].

IC50 & Target[1]

CDK4

 

CDK6

 

体外研究
(In Vitro)

Abemaciclib metabolite M18 hydrochloride exhibits T1/2 of 43.1 hr in plasma in healthy subjects[3].
CDK4/6 inhibitors’ chief mechanism of action is inhibition of retinoblastoma (RB) protein phosphorylation and thus the induction of cell cycle arrest, CDK4/6 inhibitors alter cancer cell biology in other ways[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

CDK4/6 inhibitors results T-cell persistence and immunologic memory increasing in mice receiving tumor-specific CD8+ T cells[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

494.54

Formula

C25H28F2N8O

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Abemaciclib metabolite M18
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