APOBEC1 - apolipoprotein B mRNA editing enzyme catalytic subunit 1 Gene

中文名称：载脂蛋白 B mRNA 编辑酶催化亚基 1

种属: Homo sapiens

同用名: BEDP; HEPR; CDAR1; APOBEC-1

基因 ID: 339 | 基因类型: protein coding

关于 APOBEC1

Cytogenetic location: 12p13.31 Genomic coordinates (GRCh38): 12:7,649,400-7,670,599 (from NCBI)

This gene has 2 transcripts (splice variants), 143 orthologues and 9 paralogues. Biased expression in duodenum (RPKM 22.2), small intestine (RPKM 18.5) and 1 other tissue.

功能概要

该基因编码胞苷脱氨酶家族的一个成员。编码的蛋白质与 APOBEC1 互补因子 (ACF) 和 APOBEC1 刺激蛋白 (ASP) 形成多蛋白编辑全酶。这种全酶参与载脂蛋白 B 和神经纤维瘤病 1 mRNA 中 C 到 U 核苷酸碱基的编辑。已发现该基因编码不同异构体的多个转录变体。[RefSeq 提供，2015 年 2 月]

This gene encodes a member of the cytidine deaminase Enzyme family. The encoded protein forms a multiple-protein editing holoenzyme with APOBEC1 complementation factor (ACF) and APOBEC1 stimulating protein (ASP). This holoenzyme is involved in the editing of C-to-U nucleotide bases in apolipoprotein B and neurofibromatosis-1 mRNAs. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2015]

APOBEC1 基因产物(3)

mRNA	Protein	Name
NM_001304566.1	NP_001291495.1	C->U-editing enzyme APOBEC-1 isoform a
NM_001644.5	NP_001635.2	C->U-editing enzyme APOBEC-1 isoform a
NM_005889.4	NP_005880.2	C->U-editing enzyme APOBEC-1 isoform b

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	10669759	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in cytidine to uridine editing	IDA IDA: 通过直接分析推断	24916387	GOA
involved in mRNA modification	IDA IDA: 通过直接分析推断	11134005	GOA
involved in negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	IDA IDA: 通过直接分析推断	12881431	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of apolipoprotein B mRNA editing enzyme complex	IDA IDA: 通过直接分析推断	24916387	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	22580899	GOA
located in nucleus	IDA IDA: 通过直接分析推断	12881431	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

APOBEC1 蛋白结构

APOBEC_N

0
100
200
236 a.a.

蛋白主名

其他名称

C->U-editing enzyme APOBEC-1

apolipoprotein B mRNA editing enzyme complex-1

APOBEC1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	APOBEC1	P41238	KRTAP19-5	Homo sapiens	Q3LI72	Y2H Prey Pooling	32296183
Intra	APOBEC1	P41238	KRTAP19-5	Homo sapiens	Q3LI72	Validated Y2H	32296183
Intra	APOBEC1	P41238	KRTAP19-5	Homo sapiens	Q3LI72	Y2H Array	32296183
Intra	APOBEC1	P41238	UFSP2	Homo sapiens	Q9NUQ7	Validated Y2H	32296183
Intra	APOBEC1	P41238	KRTAP6-2	Homo sapiens	Q3LI66	Y2H Prey Pooling	32296183
Intra	APOBEC1	P41238	KRTAP6-2	Homo sapiens	Q3LI66	Y2H Array	32296183
Intra	APOBEC1	P41238	KRTAP6-2	Homo sapiens	Q3LI66	Validated Y2H	32296183
Intra	APOBEC1	P41238	KRTAP6-1	Homo sapiens	Q3LI64	Validated Y2H	32296183
Intra	APOBEC1	P41238	KRTAP6-1	Homo sapiens	Q3LI64	Y2H Array	32296183
Intra	APOBEC1	P41238	KRTAP6-1	Homo sapiens	Q3LI64	Y2H Prey Pooling	32296183
Intra	APOBEC1	P41238	NOTO	Homo sapiens	A8MTQ0	Y2H Prey Pooling	32296183
Intra	APOBEC1	P41238	NOTO	Homo sapiens	A8MTQ0	Y2H Array	32296183
Intra	APOBEC1	P41238	CDK6	Homo sapiens	Q00534	Validated Y2H	32296183
Intra	APOBEC1	P41238	HNRNPF	Homo sapiens	P52597	Validated Y2H	32296183
Intra	APOBEC1	P41238	HNRNPK	Homo sapiens	P61978-2	Y2H Prey Pooling	32296183
Intra	APOBEC1	P41238	HNRNPK	Homo sapiens	P61978-2	Validated Y2H	32296183
Intra	APOBEC1	P41238	HNRNPK	Homo sapiens	P61978-2	Y2H Array	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Neurofibromatosis

Neurofibromatoses	Acoustic Neurofibromatosis
Central Neurofibromatosis	Peripheral Neurofibromatosis
Recklinghausen'S Neurofibromatosis	Von Reklinghausen Disease
Neurofibromatosis Type 1

Immunodeficiency With Hyper-Igm, Type 2

HIGM2	Hyper-Igm Syndrome Type 2
Hyper-Igm Syndrome 2	Immunodeficiency With Hyper-Igm Type 2
Activation-Induced Cytidine Deaminase Deficiency	Aid Deficiency
Immunodeficiency With Hyper Igm Type 2	Hyper Igm Syndrome 2
Immunodeficiency With Hyper-Igm 2	Hyper-Igm Immunodeficiency Type 2
Immunodeficiency, With Hyper Igm, Type 2	Hyper-Igm Immunodeficiency Syndrome, Type 2

Immunodeficiency With Hyper-Igm, Type 1

Immunodeficiency, X-Linked, With Hyper-Igm	Hyper Igm Syndrome
HIGM1	Xhim
Hyper-Igm Syndrome	Higm
Hyper-Igm Syndrome 1	Immunodeficiency 3
Imd3	Immunodeficiency With Hyper-Igm
Immunodeficiency With Hyper Igm Type 1	Ihis
X-Linked Hyper Igm Syndrome	Hyper-Igm Immunodeficiency, X-Linked
Hyper Igm Immunodeficiency, X-Linked	Hyper Igm Syndrome 1
X-Linked Immunodeficiency With Hyper-Igm 1	Immunodeficiency, With Hyper Igm
Immunodeficiency, With Hyper Igm, Type 1	Hyper-Igm Immunodeficiency Syndrome, Type 1
Hyperimmunoglobulin M Syndrome

Neurofibromatosis, Type I

Von Recklinghausen Disease	Neurofibromatosis 1
Neurofibromatosis, Type 1	NF1
Neurofibromatosis, Peripheral Type	Neurofibromatosis Type I
Neurofibromatosis Type 1 Due To Nf1 Mutation Or Intragenic Deletion	Familial Spinal Neurofibromatosis
Fsnf	Peripheral Neurofibromatosis
Von Recklinghausen'S Neurofibromatosis	Von Recklinghausen Disease Due To Nf1 Mutation Or Intragenic Deletion
Neurofibromatosis Peripheral Type	Von Recklinghausen Syndrome
Neurofibromatosis Type 1	Von Recklinghausen Neuropathy
Nf1 - [Neurofibromatosis Type 1]	Recklinghausen Disease

Immune Deficiency Disease

Immunodeficiency	Primary Immunodeficiency
Primary Immunodeficiency Disease	Immunologic Deficiency Syndromes
Hypoimmunity	Immune Deficiency Disorder
Immunodeficiency Syndrome	Immune Disorder
Primary Immune Deficiency Disorder	Immune System Diseases
Human Immunodeficiency Virus Infection	Hiv - [Human Immunodeficiency Virus Infection]
Hiv Positive Nos	Hiv Disease
Acquired Immune Deficiency Syndrome-Related Complex	Aids-Like Syndrome
Aids-Related Complex Nos	Arc - [Aids-Related Complex]
Immunodeficiency Due To Human Immunodeficiency Virus Infection	Unspecified Human Immunodeficiency Virus Disease
Hiv Disease Nos	Human Immunodeficiency Virus Positive Nos
Hiv Nos	Deficiency Of Complement Initial Pathway
Deficiency Of Complement Terminal Pathway	Cfdd - [Complement Factor D Deficiency]
Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency	Nonfamilial Hypogammaglobulinaemia
Common Variable Immune Deficiency	Nonfamilial Agammaglobulinaemia
Common Variable Agammaglobulinaemia	Agammaglobulinaemia Nos
Agammaglobulinaemia Antibody Deficiency Syndrome	Hypogammaglobulinaemia Antibody Deficiency Syndrome
Acquired Agammaglobulinaemia Nos	Hypogammaglobulinaemia Nos
Hyper Igm

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS00834	APOBEC1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	APOBEC1	MGD	MGI:103298
Bos taurus	APOBEC1	VGNC	VGNC:26027
Rattus norvegicus	APOBEC1	RGD	RGD:2133
Canis familiaris	APOBEC1	VGNC	VGNC:37995

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沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

APOBEC1 - apolipoprotein B mRNA editing enzyme catalytic subunit 1 Gene

关于 APOBEC1

功能概要

APOBEC1 基因产物(3)

APOBEC1 蛋白结构

APOBEC1 蛋白互作信息

关联疾病

直系同源

热门区域

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APOBEC1 - apolipoprotein B mRNA editing enzyme catalytic subunit 1 Gene

关于 APOBEC1

功能概要

APOBEC1 基因产物(3)

APOBEC1 蛋白结构

APOBEC1 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z