CDC45 - cell division cycle 45 Gene

中文名称：细胞分裂周期 45

种属: Homo sapiens

同用名: CDC45L; MGORS7; CDC45L2; PORC-PI-1

基因 ID: 8318 | 基因类型: protein coding

关于 CDC45

Cytogenetic location: 22q11.21 Genomic coordinates (GRCh38): 22:19,479,466-19,520,612 (from NCBI)

This gene has 14 transcripts (splice variants), 205 orthologues and is associated with 3 phenotypes. Biased expression in testis (RPKM 11.5), bone marrow (RPKM 6.8) and 11 other tissues.

功能概要

由该基因编码的蛋白质通过与酿酒酵母 Cdc45 的高度相似性得到鉴定，Cdc45 是启动 DNA 复制所需的必需蛋白质。 Cdc45 是高度保守的多蛋白复合物的成员，包括 Cdc6/Cdc18、微型染色体维持蛋白 (MCM) 和 DNA 聚合酶，这对于真核生物中 DNA 复制的早期步骤很重要。这种蛋白质已被证明与 MCM7 和 DNA 聚合酶 α 相互作用。对非洲爪蟾中相似基因的研究表明，这种蛋白质在将 DNA 聚合酶 α 加载到染色质上的过程中起着关键作用。交替剪接导致多个转录本变体。[RefSeq 提供，2013 年 7 月]

The protein encoded by this gene was identified by its strong similarity with Saccharomyces cerevisiae Cdc45, an essential protein required to the initiation of DNA replication. Cdc45 is a member of the highly conserved multiprotein complex including Cdc6/Cdc18, the minichromosome maintenance proteins (MCMs) and DNA Polymerase, which is important for early steps of DNA replication in eukaryotes. This protein has been shown to interact with MCM7 and DNA Polymerase alpha. Studies of the similar gene in Xenopus suggested that this protein play a pivotal role in the loading of DNA Polymerase alpha onto chromatin. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

CDC45 基因产物(4)

mRNA	Protein	Name
NM_001178010.2	NP_001171481.1	cell division control protein 45 homolog isoform 1
NM_001178011.2	NP_001171482.1	cell division control protein 45 homolog isoform 3
NM_001369291.1	NP_001356220.1	cell division control protein 45 homolog isoform 4 precursor
NM_003504.5	NP_003495.1	cell division control protein 45 homolog isoform 2

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	10518787	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in DNA unwinding involved in DNA replication	IDA IDA: 通过直接分析推断	22474384	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of CMG complex	IPI IPI: 通过物理相互作用推断	22474384	GOA
located in ciliary basal body	IDA IDA: 通过直接分析推断	29257953	GOA
located in nucleus	IDA IDA: 通过直接分析推断	21383955	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CDC45 蛋白结构

CDC45

0
100
200
300
400
500
566 a.a.

蛋白主名

其他名称

cell division control protein 45 homolog

CDC45 cell division cycle 45 homolog

CDC45 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	CDC45	O75419	RAB4B	Homo sapiens	P61018	Validated Y2H	32296183
种属内	CDC45	O75419	RAB4B	Homo sapiens	P61018	Y2H Array	32296183
种属内	CDC45	O75419	RAB4B	Homo sapiens	P61018	Y2H Prey Pooling	32296183
种属内	CDC45	O75419	CLSPN	Homo sapiens	Q9HAW4	Pull Down	23910567
种属内	CDC45	O75419	CLSPN	Homo sapiens	Q9HAW4	Anti Bait CoIP	23910567
种属内	CDC45	O75419	CLSPN	Homo sapiens	Q9HAW4	Anti Tag CoIP	33961781
种属内	CDC45	O75419	TOPBP1	Homo sapiens	Q92547	Pull Down	17887956
种属内	CDC45	O75419	TOPBP1	Homo sapiens	Q92547	Anti Bait CoIP	17887956
种属内	CDC45	O75419	CDKN1A	Homo sapiens	P38936	PLA	25241761
种属内	CDC45	O75419	ZRANB1	Homo sapiens	Q9UGI0	Validated Y2H	32296183
种属内	CDC45	O75419	ZRANB1	Homo sapiens	Q9UGI0	Y2H Array	32296183
种属内	CDC45	O75419	ZRANB1	Homo sapiens	Q9UGI0	Y2H Prey Pooling	32296183
种属内	CDC45	O75419	RPA2	Homo sapiens	P15927	Pull Down	23910567
种属内	CDC45	O75419	RPA2	Homo sapiens	P15927	Anti Bait CoIP	23910567
种属内	CDC45	O75419	DDIT4L	Homo sapiens	Q96D03	Validated Y2H	32296183
种属内	CDC45	O75419	DDIT4L	Homo sapiens	Q96D03	Y2H Array	32296183
种属内	CDC45	O75419	DDIT4L	Homo sapiens	Q96D03	Y2H Prey Pooling	32296183
种属内	CDC45	O75419	GINS4	Homo sapiens	Q9BRT9	Anti Tag CoIP	33961781
种属内	CDC45	O75419	GINS4	Homo sapiens	Q9BRT9	BiFC	19805216
种属内	CDC45	O75419	CEP55	Homo sapiens	Q53EZ4	Y2H Array	32296183
种属内	CDC45	O75419	CEP55	Homo sapiens	Q53EZ4	Y2H Prey Pooling	32296183
种属内	CDC45	O75419	CEP55	Homo sapiens	Q53EZ4	Y2H Array	31515488
种属内	CDC45	O75419	CEP55	Homo sapiens	Q53EZ4	Validated Y2H	32296183
种属内	CDC45	O75419	CEP55	Homo sapiens	Q53EZ4	Y2H Array	25416956

种属间: 跨种属相互作用 种属内: 同种属相互作用

CDC45 抗体

目录号	产品名	应用	反应物种
HY-P83413	CDC45 Antibody (YA3158)	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat

关联疾病

疾病名称

别名

Meier-Gorlin Syndrome 7

MGORS7

Meier-Gorlin Syndrome, Type 7

Meier-Gorlin Syndrome 1

Meier-Gorlin Syndrome	Ear, Patella, Short Stature Syndrome
Microtia, Absent Patellae, Micrognathia Syndrome	MGORS1
Eps	Ear-Patella-Short Stature Syndrome
Ear Patella Short Stature Syndrome	Microtia Absent Patellae Micrognathia Syndrome
Meier-Gorlin Syndrome, Type 1

Genitourinary Tract Anomalies

Digeorge Syndrome

Chromosome 22q11.2 Deletion Syndrome	DGS
Hypoplasia Of Thymus And Parathyroids	Third And Fourth Pharyngeal Pouch Syndrome
22q11.2 Deletion Syndrome	Digeorge Sequence
Digeorge'S Syndrome	Pharyngeal Pouch Syndrome
Di-George Syndrome	Shprintzen Syndrome

Rapadilino Syndrome

Absent Thumbs, Dislocated Joints, Long Face With Narrow Palpebral Fissures, Long Slender Nose, Arched Palate	Radial And Patellar Aplasia
Radial And Patellar Hypoplasia	RAPADILINOS

Baller-Gerold Syndrome

BGS	Craniosynostosis With Radial Defects
Craniosynostosis-Radial Aplasia Syndrome	Craniosynostosis Radial Aplasia Syndrome

Ichthyosis, Congenital, Autosomal Recessive 9

Autosomal Recessive Congenital Ichthyosis 9	ARCI9
Ichthyosis, Congenital, Autosomal Recessive, Type 9

Isolated Growth Hormone Deficiency, Type Ia

Ighd Ia	Primordial Dwarfism
Isolated Growth Hormone Deficiency Type Ia	Sexual Ateleiotic Dwarfism
Pituitary Dwarfism I	IGHD1A
Illig-Type Growth Hormone Deficiency	Growth Hormone Deficiency, Isolated, Type Ia
Congenital Ighd Type Ia	Congenital Isolated Gh Deficiency Type Ia
Congenital Isolated Growth Hormone Deficiency Type Ia	Pituitary Dwarfism 1
Growth Hormone Deficiency, Isolated, Autosomal Recessive	Autosomal Recessive Isolated Growth Hormone Deficiency
Isolated Growth Hormone Deficiency Type 1a	Congenital Ighd
Congenital Isolated Gh Deficiency	Congenital Isolated Growth Hormone Deficiency
Growth Hormone Deficiency, Isolated Autosomal Recessive	Illig Type Growth Hormone Deficiency
Non-Acquired Isolated Growth Hormone Deficiency	Growth Hormone Deficiency, Isolated, 1a
Growth Hormone Deficiency Isolated Autosomal Recessive	Dwarfism, Primordial
Dwarfism

Seckel Syndrome

Microcephalic Primordial Dwarfism	Bird-Headed Dwarfism
Harper'S Syndrome	Virchow-Seckel Dwarfism
Nanocephalic Dwarfism	Sckl
Seckel-Type Dwarfism

Chromosome 2q35 Duplication Syndrome

Syndactyly	Syndactyly Type 1
Sdty1	Zygodactyly
Syndactyly, Type I	Sd1
Syndactyly, Type 1, With Or Without Craniosynostosis	Symphalangism
Non-Syndromic Syndactyly	Symphalangy
Webbing Of Digits	Syndactyly, Type 1

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

Velocardiofacial Syndrome

Shprintzen Syndrome	VCFS
Chromosome 22q11.2 Deletion Syndrome	Vcf Syndrome
Shprintzen Vcf Syndrome	Vcf-Velocardiofacial Syndrome
Velo-Cardio-Facial Syndrome	Digeorge Syndrome
22q11 Deletion Syndrome	Conotruncal Anomaly Face Syndrome

Craniosynostosis

Premature Closure Of Cranial Sutures	Craniostenosis
Craniosynostosis Syndrome	Cso
Craniosynostoses	Congenital Ossification Of Cranial Sutures
Congenital Ossification Of Sutures Of Skull	Craniostosis
Imperfect Fusion Of Skull	Congenital Imperfect Closure Skull
Imperfect Closure Skull	Premature Closure Cranium Sutures
Deficiency Of Craniofacial Axis

Chromosome 22q11.2 Deletion Syndrome, Distal

22q11.2 Deletion Syndrome	Autosomal Dominant Opitz G/Bbb Syndrome
Catch22	Cayler Cardiofacial Syndrome
Conotruncal Anomaly Face Syndrome	Digeorge Syndrome
Sedlackova Syndrome	Shprintzen Syndrome
Velocardiofacial Syndrome	22q11.2 Distal Deletion Syndrome
Distal 22q11.2 Microdeletion Syndrome	22q11.2ds
Vcfs	Velo-Cardio-Facial Syndrome
Distal Chromosome 22q11.2 Deletion Syndrome	Chromosome 22q11.2 Deletion Syndrome Distal
Chromosome 22q11.2 Deletion Syndrome	Deletion 22q11.2 Syndrome
22q11ds	Catch 22
Digeorge Sequence	Microdeletion 22q11.2
Monosomy 22q11	Takao Syndrome
Distal Del(22)(Q11.2)	Distal Monosomy 22q11.2
Catch 22 Syndrome	Chromosome Deletion Syndrome 22q11.2, Distal

Fanconi Anemia, Complementation Group A

Fanconi Anemia	Fanconi Pancytopenia
Fanconi Anemia Complementation Group A	FANCA
Fa	Fanconi Panmyelopathy
Fanconi'S Anemia	Fanconi Anaemia
Fanconi'S Anaemia	Fanconi Hypoplastic Anemia
Estren-Dameshek Variant Of Fanconi Anemia	Estren-Dameshek Variant Of Fanconi Pancytopenia
Fanconi Anemia Estren-Dameshek Variant	Fanconis Anemia

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS02306	CDC45 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	CDC45	VGNC	VGNC:39007
Mus musculus	CDC45	MGD	MGI:1338073
Rattus norvegicus	CDC45	RGD	RGD:1590928
Bos taurus	CDC45	VGNC	VGNC:27079
Felis catus	CDC45	VGNC	VGNC:60662
Macaca mulatta	CDC45	VGNC	VGNC:70800

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