2. Gene
  3. RPA2 - replication protein A2 Gene

RPA2 - replication protein A2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：复制蛋白 A2

种属: Homo sapiens

同用名: REPA2; RPA32; RP-A p32; RP-A p34

基因 ID: 6118 | 基因类型: protein coding

关于 RPA2

Cytogenetic location: 1p35.3 Genomic coordinates (GRCh38): 1:27,891,524-27,914,797 (from NCBI)

This gene has 5 transcripts (splice variants), 244 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 29.0), lymph node (RPKM 26.6) and 25 other tissues.

功能概要

该基因编码异源三聚体复制蛋白 A (RPA) 复合物的一个亚基，与单链 DNA (ssDNA) 结合，形成核蛋白复合物，在 DNA 代谢中起重要作用，参与 DNA 复制、修复、重组、端粒维持，并通过激活共济失调毛细血管扩张和 Rad3 相关蛋白 (ATR) 激酶来协调细胞对 DNA 损伤的反应。 RPA 复合物保护单链 DNA 免受核酸酶的侵害，防止形成会干扰修复的二级结构，并协调不同基因组维持因子的募集和离开。异源三聚体复合物具有两种不同的 ssDNA 结合模式，即低亲和力和高亲和力模式，具体取决于复合物的寡核苷酸/寡糖结合 (OB) 域，并且结合的 DNA 长度不同。该亚基包含一个参与高亲和力 DNA 结合的 OB 结构域，并且在其羧基末端还包含一个有翼螺旋结构域，它与许多基因组维持蛋白相互作用。 RPA 复合物的翻译后修饰也在协调不同的损伤反应途径中发挥作用。[RefSeq 提供，2017 年 9 月]

This gene encodes a subunit of the heterotrimeric Replication Protein A (RPA) complex, which binds to single-stranded DNA (ssDNA), forming a nucleoprotein complex that plays an important role in DNA metabolism, being involved in DNA replication, repair, recombination, telomere maintenance, and co-ordinating the cellular response to DNA damage through activation of the ataxia telangiectasia and Rad3-related protein (ATR) kinase. The RPA complex protects single-stranded DNA from nucleases, prevents formation of secondary structures that would interfere with repair, and co-ordinates the recruitment and departure of different genome maintenance factors. The heterotrimeric complex has two different modes of ssDNA binding, a low-affinity and high-affinity mode, determined by which oligonucleotide/oligosaccharide-binding (OB) domains of the complex are utilized, and differing in the length of DNA bound. This subunit contains a single OB domain that participates in high-affinity DNA binding and also contains a winged helix domain at its carboxy terminus, which interacts with many genome maintenance protein. Post-translational modifications of the RPA complex also plays a role in co-ordinating different damage response pathways. [provided by RefSeq, Sep 2017]

RPA2 基因产物(5)

mRNA Protein Name
NM_001286076.2 NP_001273005.1 replication protein A 32 kDa subunit isoform 2
NM_001297558.1 NP_001284487.1 replication protein A 32 kDa subunit isoform 3
NM_001355128.2 NP_001342057.1 replication protein A 32 kDa subunit isoform 2
NM_001355129.2 NP_001342058.1 replication protein A 32 kDa subunit isoform 4
NM_002946.5 NP_002937.1 replication protein A 32 kDa subunit isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables G-rich strand telomeric DNA binding IDA
IDA: 通过直接分析推断
24747047 GOA
enables damaged DNA binding IDA
IDA: 通过直接分析推断
7700386 GOA
enables enzyme binding IPI
IPI: 通过物理相互作用推断
19793862 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
2159011 GOA
enables protein phosphatase binding IPI
IPI: 通过物理相互作用推断
20154705 GOA
enables single-stranded DNA binding IDA
IDA: 通过直接分析推断
19010961 GOA
enables ubiquitin protein ligase binding IPI
IPI: 通过物理相互作用推断
21504906 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in DNA replication IDA
IDA: 通过直接分析推断
2406247 GOA
involved in DNA replication IMP
IMP: 通过突变表型推断
9430682 GOA
involved in base-excision repair IDA
IDA: 通过直接分析推断
9765279 GOA
involved in double-strand break repair via homologous recombination IMP
IMP: 通过突变表型推断
17765923 GOA
involved in mismatch repair IMP
IMP: 通过突变表型推断
9430682 GOA
involved in mitotic G1 DNA damage checkpoint signaling IMP
IMP: 通过突变表型推断
21731742 GOA
involved in nucleotide-excision repair IMP
IMP: 通过突变表型推断
9430682 GOA
involved in protein localization to chromosome IDA
IDA: 通过直接分析推断
27723717 GOA
involved in regulation of DNA damage checkpoint IMP
IMP: 通过突变表型推断
21504906 GOA
involved in regulation of double-strand break repair via homologous recombination IMP
IMP: 通过突变表型推断
20154705 GOA
involved in telomere maintenance IMP
IMP: 通过突变表型推断
17959650 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of DNA replication factor A complex IDA
IDA: 通过直接分析推断
2406247 GOA
part of DNA replication factor A complex IPI
IPI: 通过物理相互作用推断
11927569 GOA
colocalizes with PML body IDA
IDA: 通过直接分析推断
17959650 GOA
located in PML body IDA
IDA: 通过直接分析推断
12814551 GOA
located in chromatin IDA
IDA: 通过直接分析推断
10336450 GOA
colocalizes with chromosome, telomeric region IDA
IDA: 通过直接分析推断
17959650 GOA
located in nucleus IDA
IDA: 通过直接分析推断
10982866 GOA
colocalizes with site of double-strand break IDA
IDA: 通过直接分析推断
21504906 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RPA2 蛋白结构

tRNA_anti-codon

tRNA_anti-codon: OB-fold nucleic acid binding domain (74 - 148)

RPA_C

RPA_C: Replication protein A C terminal (166 - 262)

  • 0
  • 100
  • 200
  • 270 a.a.
蛋白主名 其他名称

replication protein A 32 kDa subunit

RF-A protein 2

RPA2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra RPA2 P15927 UNG Homo sapiens P13051
Y2H
10982866
Intra RPA2 P15927 UNG Homo sapiens P13051
ITC
24910198
Intra RPA2 P15927 RFWD3 Homo sapiens Q6PCD5
TAP
24126761
Intra RPA2 P15927 TIPIN Homo sapiens Q9BVW5
TAP
24126761
Intra RPA2 P15927 TIPIN Homo sapiens Q9BVW5
ITC
24910198
Intra RPA2 P15927 XPA Homo sapiens P23025
Y2H
10982866
Intra RPA2 P15927 XPA Homo sapiens P23025
Validated Y2H
32296183
Intra RPA2 P15927 GAPDH Homo sapiens P04406
Y2H Pooling
16169070
Intra RPA2 P15927 CDC45 Homo sapiens O75419
Pull Down
23910567
Intra RPA2 P15927 CCNC Homo sapiens P24863
Validated Y2H
32296183
Intra RPA2 P15927 SMARCAL1 Homo sapiens Q9NZC9
X-Ray Diffraction
24910198
Intra RPA2 P15927 SMARCAL1 Homo sapiens Q9NZC9
GMS
24910198
Intra RPA2 P15927 SMARCAL1 Homo sapiens Q9NZC9
TAP
24126761
Intra RPA2 P15927 SMARCAL1 Homo sapiens Q9NZC9
ITC
24910198
Intra RPA2 P15927 RPA1 Homo sapiens P27694
Y2H
15965237
Intra RPA2 P15927 RPA1 Homo sapiens P27694
TAP
24126761
Intra RPA2 P15927 RPA1 Homo sapiens P27694
Anti Tag CoIP
33961781
Intra RPA2 P15927 RPA1 Homo sapiens P27694
Anti Tag CoIP
34591612
Intra RPA2 P15927 RPA1 Homo sapiens P27694
Validated Y2H
32296183
Intra RPA2 P15927 RPA1 Homo sapiens P27694
Anti Bait CoIP
24126761
Intra RPA2 P15927 RPA3 Homo sapiens P35244
Anti Tag CoIP
34591612
Intra RPA2 P15927 RPA3 Homo sapiens P35244
Y2H
19338310
Intra RPA2 P15927 RPA3 Homo sapiens P35244
TAP
24981860
Intra RPA2 P15927 RPA3 Homo sapiens P35244
TAP
24126761
Intra RPA2 P15927 RPA3 Homo sapiens P35244
Anti Tag CoIP
33961781
Intra RPA2 P15927 RPA3 Homo sapiens P35244
Y2H
10982866
Intra RPA2 P15927 EIF4EBP3 Homo sapiens O60516
Anti Tag CoIP
22684010
Intra RPA2 P15927 SERTAD3 Homo sapiens Q9UJW9
Y2H
10982866
Intra RPA2 P15927 SERTAD3 Homo sapiens Q9UJW9
Pull Down
10982866
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Ataxia-Telangiectasia

Ataxia Telangiectasia

Louis-Bar Syndrome

AT

At1

Ataxia-Telangiectasia Syndrome

Ataxia - Telangiectasia Variant

Boder-Sedgwick Syndrome

Louis Bar Syndrome

Cerebello-Oculocutaneous Telangiectasia

Immunodeficiency With Ataxia Telangiectasia

A-T

Ataxia Telangiectasia Syndrome

Atm

Telangiectasia, Cerebello-Oculocutaneous

Ataxia-Telangiectasia Variant
Xeroderma Pigmentosum, Variant Type

Xeroderma Pigmentosum

XPV

Xeroderma Pigmentosum Variant Type

Xeroderma Pigmentosum With Normal Dna Repair Rates

Photosensitivity With Defective Dna Synthesis

Xp

De Sanctis-Cacchione Syndrome

Desanctis-Cacchione Syndrome

Xeroderma Pigmentosa

Xerodermic Idiocy

Xeroderma Pigmentosum Variant

Xp - [Xeroderma Pigmentosum]

Atrophoderma Pigmentosum
Bloom Syndrome

BLM

Bs

Bls

Bloom-Torre-Machacek Syndrome

Microcephaly, Growth Restriction, And Increased Sister Chromatid Exchange 1

Mgrisce1

Congenital Telangiectatic Erythema

Congenital Telangiectatic Erythema Syndrome

Growth Deficiency, Sun-Sensitive, Telangiectatic, Hypo And Hyperpigmented Skin, Predisposition To Malignancy And Chromosomal Instability

Bloom'S Syndrome

Bsyn
Xeroderma Pigmentosum, Complementation Group A

Xeroderma Pigmentosum Group A

Xp1

Xeroderma Pigmentosum, Group A

XPA

Xeroderma Pigmentosum I

Xeroderma Pigmentosum Complementation Group A

Xp Group A

Xp, Group A

Xeroderma Pigmentosum 1

Xeroderma Pigmentosum, Type 1

XP-A
Xeroderma Pigmentosum, Complementation Group C

Xeroderma Pigmentosum, Group C

XPC

Xpcc

Xeroderma Pigmentosum Iii

Xp3

Xeroderma Pigmentosum Group C

Xp Group C

Xp, Group C

Xeroderma Pigmentosum, Type 3

Xeroderma Pigmentosum Complementation Group C

XP-C
Seckel Syndrome

Microcephalic Primordial Dwarfism

Bird-Headed Dwarfism

Harper'S Syndrome

Virchow-Seckel Dwarfism

Nanocephalic Dwarfism

Sckl

Seckel-Type Dwarfism
Fanconi Anemia, Complementation Group A

Fanconi Anemia

Fanconi Pancytopenia

Fanconi Anemia Complementation Group A

FANCA

Fa

Fanconi Panmyelopathy

Fanconi'S Anemia

Fanconi Anaemia

Fanconi'S Anaemia

Fanconi Hypoplastic Anemia

Estren-Dameshek Variant Of Fanconi Anemia

Estren-Dameshek Variant Of Fanconi Pancytopenia

Fanconi Anemia Estren-Dameshek Variant

Fanconis Anemia
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12143 RPA2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus RPA2 MGD MGI:1339939
Bos taurus RPA2 VGNC VGNC:34095
Felis catus RPA2 VGNC VGNC:80345
Macaca mulatta RPA2 VGNC VGNC:100064
Rattus norvegicus RPA2 RGD RGD:619714
Canis familiaris RPA2 VGNC VGNC:45703
Others RPA2 NCBI
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