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  3. TIPIN - TIMELESS interacting protein Gene

TIPIN - TIMELESS interacting protein Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：TIMELESS 相互作用蛋白

种属: Homo sapiens

基因 ID: 54962 | 基因类型: protein coding

关于 TIPIN

Cytogenetic location: 15q22.31 Genomic coordinates (GRCh38): 15:66,336,191-66,386,717 (from NCBI)

This gene has 6 transcripts (splice variants) and 203 orthologues. Broad expression in testis (RPKM 3.8), lymph node (RPKM 1.8) and 24 other tissues.

功能概要

由该基因编码的蛋白质是复制体复合体的一部分，复制体复合体是一组支持 DNA 复制的蛋白质。它结合参与昼夜节律调节的 TIM，并有助于保护细胞免受 DNA 损伤和压力。已发现该基因的两个假基因和两个编码不同亚型的转录本变体。[RefSeq 提供，2014 年 7 月]

The protein encoded by this gene is part of the replisome complex, a group of proteins that support DNA replication. It binds TIM, which is involved in circadian rhythm regulation, and aids in protecting cells against DNA damage and stress. Two pseudogenes and two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

TIPIN 基因产物(9)

mRNA Protein Name
NM_001289986.2 NP_001276915.1 TIMELESS-interacting protein isoform 2
NM_001398281.1 NP_001385210.1 TIMELESS-interacting protein isoform 1
NM_001398282.1 NP_001385211.1 TIMELESS-interacting protein isoform 1
NM_001398283.1 NP_001385212.1 TIMELESS-interacting protein isoform 1
NM_001398284.1 NP_001385213.1 TIMELESS-interacting protein isoform 1
NM_001398285.1 NP_001385214.1 TIMELESS-interacting protein isoform 2
NM_001398286.1 NP_001385215.1 TIMELESS-interacting protein isoform 2
NM_001398287.1 NP_001385216.1 TIMELESS-interacting protein isoform 2
NM_017858.3 NP_060328.3 TIMELESS-interacting protein isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
17102137 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in DNA replication checkpoint signaling IMP
IMP: 通过突变表型推断
17102137 GOA
involved in cell cycle phase transition IMP
IMP: 通过突变表型推断
17102137 GOA
involved in mitotic intra-S DNA damage checkpoint signaling IMP
IMP: 通过突变表型推断
17102137 GOA
involved in positive regulation of cell population proliferation IMP
IMP: 通过突变表型推断
17102137 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in chromatin IDA
IDA: 通过直接分析推断
17102137 GOA
located in nucleus IDA
IDA: 通过直接分析推断
17102137 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TIPIN 蛋白结构

Swi3

Swi3: Replication Fork Protection Component Swi3 (66 - 147)

  • 0
  • 100
  • 200
  • 301 a.a.
蛋白主名 其他名称

TIMELESS-interacting protein

CSM3 homolog

TIPIN 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra TIPIN Q9BVW5 GSC2 Homo sapiens O15499
Y2H Prey Pooling
32296183
Intra TIPIN Q9BVW5 GSC2 Homo sapiens O15499
Y2H Array
32296183
Intra TIPIN Q9BVW5 TIMELESS Homo sapiens Q9UNS1
Chromatography
32705708
Intra TIPIN Q9BVW5 TIMELESS Homo sapiens Q9UNS1
Anti Bait CoIP
17116885
Intra TIPIN Q9BVW5 TIMELESS Homo sapiens Q9UNS1
Anti Tag CoIP
33961781
Intra TIPIN Q9BVW5 SPRED1 Homo sapiens Q7Z699
Validated Y2H
32814053
Intra TIPIN Q9BVW5 SPRED1 Homo sapiens Q7Z699
Y2H Array
32814053
Intra TIPIN Q9BVW5 SPRED1 Homo sapiens Q7Z699
Y2H Pooling
32814053
Intra TIPIN Q9BVW5 RPA2 Homo sapiens P15927
ITC
24910198
Intra TIPIN Q9BVW5 RPA2 Homo sapiens P15927
NMR
24910198
Intra TIPIN Q9BVW5 TEX11 Homo sapiens Q8IYF3
Validated Y2H
25416956
Intra TIPIN Q9BVW5 TEX11 Homo sapiens Q8IYF3
Y2H Prey Pooling
25416956
Intra TIPIN Q9BVW5 TEX11 Homo sapiens Q8IYF3
Y2H Array
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS14549 TIPIN Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris TIPIN VGNC VGNC:47382
Mus musculus TIPIN MGD MGI:1921571
Macaca mulatta TIPIN VGNC VGNC:79873
Bos taurus TIPIN VGNC VGNC:35877
Rattus norvegicus TIPIN RGD RGD:1564084
Felis catus TIPIN VGNC VGNC:80821
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