1. Gene
  2. TIMELESS - timeless circadian regulator Gene

TIMELESS - timeless circadian regulator Gene

中文名称:永恒的昼夜节律调节器

种属: Homo sapiens

同用名: TIM; TIM1; hTIM; FASPS4

基因 ID: 8914 | 基因类型: protein coding

关于 TIMELESS

Cytogenetic location: 12q13.3 Genomic coordinates (GRCh38): 12:56,416,363-56,449,426 (from NCBI)

This gene has 5 transcripts (splice variants) and 193 orthologues. Ubiquitous expression in lymph node (RPKM 8.6), bone marrow (RPKM 8.5) and 25 other tissues.

功能概要

该基因编码的蛋白质高度保守,参与损伤或应激后的细胞存活、DNA 聚合酶 epsilon 活性的增加、端粒长度的维持和上皮细胞形态发生。编码的蛋白质还在昼夜节律自动调节回路中发挥作用,与 PERIOD 基因 (PER1、PER2 和 PER3) 和其他基因相互作用,以下调 CLOCK/ARNTL 对 PER1 的激活。该基因或其表达的变化可能促进前列腺癌、肺癌、乳腺癌和精神障碍。[RefSeq 提供,2014 年 2 月]

The protein encoded by this gene is highly conserved and is involved in cell survival after damage or stress, increase in DNA Polymerase epsilon activity, maintenance of telomere length, and epithelial cell morphogenesis. The encoded protein also plays a role in the circadian rhythm autoregulatory loop, interacting with the PERIOD genes (PER1, PER2, and PER3) and Others to downregulate activation of PER1 by CLOCK/ARNTL. Changes in this gene or its expression may promote prostate Cancer, lung Cancer, breast Cancer, and mental disorders. [provided by RefSeq, Feb 2014]

TIMELESS 基因产物(2)

mRNA Protein Name
NM_001330295.2 NP_001317224.1 protein timeless homolog isoform 2
NM_003920.5 NP_003911.2 protein timeless homolog isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
15798197 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in DNA damage response IMP
IMP: 通过突变表型推断
23797032 GOA
involved in cell cycle phase transition IMP
IMP: 通过突变表型推断
17102137 GOA
involved in cellular response to bleomycin IMP
IMP: 通过突变表型推断
23797032 GOA
involved in cellular response to cisplatin IMP
IMP: 通过突变表型推断
23797032 GOA
involved in cellular response to hydroxyurea IMP
IMP: 通过突变表型推断
23797032 GOA
involved in negative regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
9856465 GOA
involved in positive regulation of double-strand break repair IMP
IMP: 通过突变表型推断
23797032 GOA
involved in positive regulation of double-strand break repair via homologous recombination IDA
IDA: 通过直接分析推断
26344098 GOA
NOT involved in regulation of cell population proliferation IMP
IMP: 通过突变表型推断
17102137 GOA
involved in regulation of circadian rhythm IMP
IMP: 通过突变表型推断
23418588 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in chromatin IDA
IDA: 通过直接分析推断
17102137 GOA
located in nucleus IDA
IDA: 通过直接分析推断
17102137 GOA
located in site of double-strand break IDA
IDA: 通过直接分析推断
26344098 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

TIMELESS 蛋白结构

TIMELESS

TIMELESS: Timeless protein (21 - 285)

TIMELESS_C

TIMELESS_C: Timeless protein C terminal region (728 - 1179)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1208 a.a.
蛋白主名 其他名称

protein timeless homolog

Tof1 homolog

TIMELESS 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
TIMELESS Q9UNS1 CHEK1 Homo sapiens O14757
Anti Tag CoIP
15798197
种属间: 跨种属相互作用 种属内: 同种属相互作用

TIMELESS 抗体

目录号 产品名 应用 反应物种
HY-P82459 TIMELESS Antibody (YA2204) WB, IHC-F, IHC-P, ICC/IF Human

关联疾病

疾病名称 别名
Advance Sleep Phase Syndrome, Familial, 4

FASPS4

Warsaw Breakage Syndrome

WABS

WBRS

Advanced Sleep Phase Syndrome

Fasps

Familial Advanced Sleep-Phase Syndrome

Advanced Sleep Phase Syndrome, Familial

Familial Advanced Sleep Phase Syndrome

Sleep Phase Syndrome, Advanced, Familial

Advanced Sleep-Phase Syndrome, Familial

Delayed Sleep Phase Disorder

Delayed Sleep Phase Syndrome

Delayed Sleep Phase Syndrome, Susceptibility To

DSPD

Delayed Sleep Phase Disorder, Susceptibility To

DSPS

Sleep Phase, Delayed, Disorder

Sleep Phase Syndrome, Delayed, Susceptibility To

Bipolar Disorder

Bipolar Depression

Manic Disorder

Depression, Bipolar

Bipolar Disorder Manic Phase

Depressive-Manic Psych.

Manic Bipolar Affective Disorder

Manic Bipolar I Disorder

Manic Depression

Manic Depressive Disorder

Mixed Bipolar Disorder

Bipolar Affective Disorder

Bipolar Affective Psychosis

Bipolar Spectrum Disorder

Manic Depressive Illness

Depression Bipolar

Bipolar Disorder, Mixed

Major Affective Disorder

Major Affective Disorder 1

Major Affective Disorder 2

Major Depressive Disorder

Seasonal Affective Disorder

Unipolar Depression

Depression

MDD

Depressive Disorder

Unipolar Depression, Susceptibility To

Major Depressive Disorder 1

Major Depressive Disorder, Response To Citalopram Therapy In

Major Depressive Disorder 2

Winter Depression

Single Major Depressive Episode

Sad

Clinical Depression

Major Depression

Depressive Syndrome

Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment

Seasonal Affective Disorder, Susceptibility To

Recurrent Major Depression

Affective Disorder, Seasonal

Depression In A Seasonal Pattern

Depression

Seasonal

Major Depressive Disorder With A Seasonal Pattern

Seasonal Depression

Seasonal Mood Disorder

Mental Depression

Recurrent Major Depressive Episodes

Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma

Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer

Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Bos taurus TIMELESS VGNC VGNC:35869
Macaca mulatta TIMELESS VGNC VGNC:78356
Rattus norvegicus TIMELESS RGD RGD:620939
Mus musculus TIMELESS MGD MGI:1321393
Canis familiaris TIMELESS VGNC VGNC:47375