UNG - uracil DNA glycosylase Gene

中文名称：尿嘧啶 DNA 糖基化酶

种属: Homo sapiens

同用名: DGU; UDG; UNG1; UNG2; HIGM4; HIGM5; UNG15

基因 ID: 7374 | 基因类型: protein coding

关于 UNG

Cytogenetic location: 12q24.11 Genomic coordinates (GRCh38): 12:109,097,597-109,110,992 (from NCBI)

This gene has 14 transcripts (splice variants), 223 orthologues and is associated with 2 phenotypes. Ubiquitous expression in adrenal (RPKM 23.4), testis (RPKM 16.9) and 25 other tissues.

功能概要

该基因编码几种尿嘧啶-DNA 糖基化酶中的一种。尿嘧啶-DNA 糖基化酶的一项重要功能是通过切割 N-糖基键并启动碱基切除修复 (BER) 途径从 DNA 分子中消除尿嘧啶来防止诱变。尿嘧啶碱基来自胞嘧啶脱氨或 dUMP 残基的错误掺入。该基因的替代启动子使用和剪接导致两种不同的亚型：线粒体 UNG1 和核 UNG2。在文献和一些数据库中，UNG2 术语被用作 CCNO 基因 (GeneID 10309) 的前一个符号，该基因已与该基因混淆。[RefSeq 提供，2010 年 11 月]

This gene encodes one of several uracil-DNA glycosylases. One important function of uracil-DNA glycosylases is to prevent mutagenesis by eliminating uracil from DNA molecules by cleaving the N-glycosylic bond and initiating the base-excision repair (BER) pathway. Uracil Bases occur from cytosine deamination or misincorporation of dUMP residues. Alternative promoter usage and splicing of this gene leads to two different isoforms: the mitochondrial UNG1 and the nuclear UNG2. The UNG2 term was used as a previous symbol for the CCNO gene (GeneID 10309), which has been confused with this gene, in the literature and some databases. [provided by RefSeq, Nov 2010]

UNG 基因产物(2)

mRNA	Protein	Name
NM_003362.4	NP_003353.1	uracil-DNA glycosylase isoform UNG1 precursor
NM_080911.3	NP_550433.1	uracil-DNA glycosylase isoform UNG2

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables damaged DNA binding	IDA IDA: 通过直接分析推断	18973764	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	10982866	GOA
enables ribosomal small subunit binding	IPI IPI: 通过物理相互作用推断	18973764	GOA
enables uracil DNA N-glycosylase activity	IDA IDA: 通过直接分析推断	12161446	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in base-excision repair	IDA IDA: 通过直接分析推断	12161446	GOA
involved in base-excision repair, AP site formation via deaminated base removal	IDA IDA: 通过直接分析推断	18973764	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in nucleoplasm	IDA IDA: 通过直接分析推断	12161446	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

UNG 蛋白结构

UDG

0
100
200
313 a.a.

蛋白主名

其他名称

uracil-DNA glycosylase

uracil-DNA glycosylase 1, uracil-DNA glycosylase 2

UNG 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	UNG	P13051	RPA2	Homo sapiens	P15927	NMR	24910198
种属内	UNG	P13051	RPA2	Homo sapiens	P15927	Y2H	10982866
种属内	UNG	P13051	RPA2	Homo sapiens	P15927	ITC	24910198

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 UNG 蛋白

目录号	产品名	蛋白编号	纯度
HY-P73562	UNG Protein, Human (His)	P13051-2 (F85-L304)	≥95%

UNG 抗体

目录号	产品名	应用	反应物种
HY-P82853	Uracil DNA Glycosylase Antibody (YA2598)	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat

关联疾病

疾病名称

别名

Immunodeficiency With Hyper-Igm, Type 5

HIGM5	Hyper-Igm Syndrome 5
Immunodeficiency With Hyper Igm Type 5	Hyper-Igm Syndrome Type 5
Hyper-Igm Syndrome Due To Ung Deficiency	Hyper-Igm Syndrome Due To Uracil N-Glycosylase
Immunodeficiency With Hyper Igm, Type 5	Hyper Igm Syndrome 5
Immunodeficiency With Hyper-Igm 5	Hyper-Igm Immunodeficiency Type 5
Immunodeficiency, With Hyper Igm, Type 5	Hyper-Igm Immunodeficiency Syndrome, Type 5

Immunodeficiency With Hyper-Igm, Type 1

Immunodeficiency, X-Linked, With Hyper-Igm	Hyper Igm Syndrome
HIGM1	Xhim
Hyper-Igm Syndrome	Higm
Hyper-Igm Syndrome 1	Immunodeficiency 3
Imd3	Immunodeficiency With Hyper-Igm
Immunodeficiency With Hyper Igm Type 1	Ihis
X-Linked Hyper Igm Syndrome	Hyper-Igm Immunodeficiency, X-Linked
Hyper Igm Immunodeficiency, X-Linked	Hyper Igm Syndrome 1
X-Linked Immunodeficiency With Hyper-Igm 1	Immunodeficiency, With Hyper Igm
Immunodeficiency, With Hyper Igm, Type 1	Hyper-Igm Immunodeficiency Syndrome, Type 1
Hyperimmunoglobulin M Syndrome

Immunodeficiency With Hyper-Igm, Type 4

HIGM4	Hyper-Igm Syndrome Type 4
Immunodeficiency With Hyper-Igm Type 4	Hyper-Igm Syndrome 4
Immunodeficiency With Hyper Igm Type 4	Hyper Igm Syndrome 4
Immunodeficiency, With Hyper Igm, Type 4

Immunodeficiency With Hyper-Igm, Type 2

HIGM2	Hyper-Igm Syndrome Type 2
Hyper-Igm Syndrome 2	Immunodeficiency With Hyper-Igm Type 2
Activation-Induced Cytidine Deaminase Deficiency	Aid Deficiency
Immunodeficiency With Hyper Igm Type 2	Hyper Igm Syndrome 2
Immunodeficiency With Hyper-Igm 2	Hyper-Igm Immunodeficiency Type 2
Immunodeficiency, With Hyper Igm, Type 2	Hyper-Igm Immunodeficiency Syndrome, Type 2

Immunodeficiency 25

Immunodeficiency Due To Defect In Cd3-Zeta	IMD25
Immunodeficiency, Type 25

Spinocerebellar Ataxia Type 1 With Axonal Neuropathy

Scan1	Spinocerebellar Ataxia With Axonal Neuropathy Type 1
Autosomal Recessive Spinocerebellar Ataxia With Axonal Neuropathy	Scan1, Tdp1-Related Spinocerebellar Ataxia With Axonal Neuropathy
Spinocerebellar Ataxia Autosomal Recessive With Axonal Neuropathy	Spinocerebellar Ataxia With Axonal Neuropathy
Spinocerebellar Ataxia, Autosomal Recessive, With Axonal Neuropathy	Ataxia, Spinocerebellar, Autosomal Recessive With Axonal Neuropathy

Xeroderma Pigmentosum, Variant Type

Xeroderma Pigmentosum	XPV
Xeroderma Pigmentosum Variant Type	Xeroderma Pigmentosum With Normal Dna Repair Rates
Photosensitivity With Defective Dna Synthesis	Xp
De Sanctis-Cacchione Syndrome	Desanctis-Cacchione Syndrome
Xeroderma Pigmentosa	Xerodermic Idiocy
Xeroderma Pigmentosum Variant	Xp - [Xeroderma Pigmentosum]
Atrophoderma Pigmentosum

Ichthyosis, Congenital, Autosomal Recessive 11

Autosomal Recessive Congenital Ichthyosis 11	Ichthyosis With Hypotrichosis, Autosomal Recessive
Arih	Ichthyosis And Follicular Atrophoderma With Hypotrichosis And Hypohidrosis
Autosomal Recessive Ichthyosis With Hypotrichosis	ARCI11
Ifah	Hypotrichosis-Congenital Ichthyosis Syndrome
Ichthyosis-Follicular Atrophoderma-Hypotrichosis Syndrome	Ichthyosis-Follicular Atrophoderma-Hypotrichosis-Hypohidrosis Syndrome
Ichthyosis-Hypotrichosis Syndrome	Ifah Syndrome
Ihs

Ovarian Clear Cell Adenocarcinoma

Immune Deficiency Disease

Immunodeficiency	Primary Immunodeficiency
Primary Immunodeficiency Disease	Immunologic Deficiency Syndromes
Hypoimmunity	Immune Deficiency Disorder
Immunodeficiency Syndrome	Immune Disorder
Primary Immune Deficiency Disorder	Immune System Diseases
Human Immunodeficiency Virus Infection	Hiv - [Human Immunodeficiency Virus Infection]
Hiv Positive Nos	Hiv Disease
Acquired Immune Deficiency Syndrome-Related Complex	Aids-Like Syndrome
Aids-Related Complex Nos	Arc - [Aids-Related Complex]
Immunodeficiency Due To Human Immunodeficiency Virus Infection	Unspecified Human Immunodeficiency Virus Disease
Hiv Disease Nos	Human Immunodeficiency Virus Positive Nos
Hiv Nos	Deficiency Of Complement Initial Pathway
Deficiency Of Complement Terminal Pathway	Cfdd - [Complement Factor D Deficiency]
Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency	Nonfamilial Hypogammaglobulinaemia
Common Variable Immune Deficiency	Nonfamilial Agammaglobulinaemia
Common Variable Agammaglobulinaemia	Agammaglobulinaemia Nos
Agammaglobulinaemia Antibody Deficiency Syndrome	Hypogammaglobulinaemia Antibody Deficiency Syndrome
Acquired Agammaglobulinaemia Nos	Hypogammaglobulinaemia Nos
Hyper Igm

Cockayne Syndrome A

Cockayne Syndrome Type 1	Cockayne Syndrome, Type A
Cockayne Syndrome Type I	CSA
Cockayne Syndrome Classic Form	Cockayne Syndrome Classical
Cockayne Syndrome Type A	Ckn1

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-E70217	Uracil DNA Glycosylase (UDG/UNG), heat-sensitive		/	否
HY-RS15478	UNG Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-112333	SC-68376	Inhibitor	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	UNG	RGD	RGD:1307200
Canis familiaris	UNG	VGNC	VGNC:48147
Macaca mulatta	UNG	VGNC	VGNC:78725
Felis catus	UNG	VGNC	VGNC:80543
Mus musculus	UNG	MGD	MGI:109352
Bos taurus	UNG	VGNC	VGNC:36677
Others	UNG	NCBI

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上海工商

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沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

UNG - uracil DNA glycosylase Gene

关于 UNG

功能概要

UNG 基因产物(2)

UNG 蛋白结构

UNG 蛋白互作信息

重组 UNG 蛋白

UNG 抗体

关联疾病

直系同源

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UNG - uracil DNA glycosylase Gene

关于 UNG

功能概要

UNG 基因产物(2)

UNG 蛋白结构

UNG 蛋白互作信息

重组 UNG 蛋白

UNG 抗体

关联疾病

相关产品

直系同源

热门区域

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B

C

F

G

H

J

L

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Q

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