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  2. RPA3 - replication protein A3 Gene

RPA3 - replication protein A3 Gene

中文名称:复制蛋白 A3

种属: Homo sapiens

同用名: REPA3; RP-A p14

基因 ID: 6119 | 基因类型: protein coding

关于 RPA3

Cytogenetic location: 7p21.3 Genomic coordinates (GRCh38): 7:7,636,518-7,718,607 (from NCBI)

This gene has 7 transcripts (splice variants) and 202 orthologues. Ubiquitous expression in lymph node (RPKM 9.0), bone marrow (RPKM 7.1) and 25 other tissues.

功能概要

启用受损的 DNA 结合活性和单链 DNA 结合活性。参与 DNA 修复和 DNA 复制。 DNA 复制因子 A 复合体的一部分。 [由基因组资源联盟提供,2022 年 4 月]

Enables damaged DNA binding activity and single-stranded DNA binding activity. Involved in DNA repair and DNA replication. Part of DNA replication factor A complex. [provided by Alliance of Genome Resources, Apr 2022]

RPA3 基因产物(1)

mRNA Protein Name
NM_002947.5 NP_002938.1 replication protein A 14 kDa subunit
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables damaged DNA binding IDA
IDA: 通过直接分析推断
7700386 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
2159011 GOA
enables single-stranded DNA binding IDA
IDA: 通过直接分析推断
19010961 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in DNA repair IDA
IDA: 通过直接分析推断
20545304 GOA
involved in DNA replication IMP
IMP: 通过突变表型推断
9430682 GOA
involved in base-excision repair IDA
IDA: 通过直接分析推断
9765279 GOA
involved in double-strand break repair via homologous recombination IMP
IMP: 通过突变表型推断
17765923 GOA
involved in mismatch repair IMP
IMP: 通过突变表型推断
9430682 GOA
involved in nucleotide-excision repair IMP
IMP: 通过突变表型推断
9430682 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of DNA replication factor A complex IDA
IDA: 通过直接分析推断
11927569 GOA
part of DNA replication factor A complex IPI
IPI: 通过物理相互作用推断
7760808 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

RPA3 蛋白结构

Rep_fac-A_3

Rep_fac-A_3: Replication factor A protein 3 (5 - 113)

  • 0
  • 100
  • 121 a.a.
蛋白主名 其他名称

replication protein A 14 kDa subunit

RF-A protein 3

RPA3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra RPA3 P35244 RPA4 Homo sapiens Q13156
Y2H
7760808
Intra RPA3 P35244 RPA1 Homo sapiens P27694
TAP
24126761
Intra RPA3 P35244 RPA2 Homo sapiens P15927
Pull Down
10982866
Intra RPA3 P35244 RPA2 Homo sapiens P15927
X-Ray Diffraction
10449415
Intra RPA3 P35244 RPA2 Homo sapiens P15927
Y2H
15965237
Intra RPA3 P35244 RPA2 Homo sapiens P15927
Y2H
10982866
Intra RPA3 P35244 RPA2 Homo sapiens P15927
TAP
24126761
Intra RPA3 P35244 RAD52 Homo sapiens P43351
TAP
24126761
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Rheumatoid Arthritis Interstitial Lung Disease

Rheumatoid Lung

Fanconi Anemia, Complementation Group A

Fanconi Anemia

Fanconi Pancytopenia

Fanconi Anemia Complementation Group A

FANCA

Fa

Fanconi Panmyelopathy

Fanconi'S Anemia

Fanconi Anaemia

Fanconi'S Anaemia

Fanconi Hypoplastic Anemia

Estren-Dameshek Variant Of Fanconi Anemia

Estren-Dameshek Variant Of Fanconi Pancytopenia

Fanconi Anemia Estren-Dameshek Variant

Fanconis Anemia

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Bos taurus RPA3 VGNC VGNC:34096
Rattus norvegicus RPA3 RGD RGD:1306810
Mus musculus RPA3 MGD MGI:1915490
Felis catus RPA3 VGNC VGNC:80672
Canis familiaris RPA3 VGNC VGNC:45704