1. Gene
  2. RAD52 - RAD52 homolog, DNA repair protein Gene

RAD52 - RAD52 homolog, DNA repair protein Gene

中文名称:RAD52 同系物,DNA 修复蛋白

种属: Homo sapiens

基因 ID: 5893 | 基因类型: protein coding

关于 RAD52

Cytogenetic location: 12p13.33 Genomic coordinates (GRCh38): 12:911,736-991,122 (from NCBI)

This gene has 19 transcripts (splice variants) and 193 orthologues. Ubiquitous expression in fat (RPKM 4.4), skin (RPKM 4.2) and 25 other tissues.

功能概要

由该基因编码的蛋白质与酿酒酵母 Rad52 具有相似性,后者是一种对 DNA 双链断裂修复和同源重组很重要的蛋白质。该基因产物显示可结合单链 DNA 末端,并介导互补 DNA 链退火所必需的 DNA-DNA 相互作用。它还被发现与 DNA 重组蛋白 RAD51 相互作用,这表明其在 RAD51 相关 DNA 重组和修复中的作用。该基因的假基因存在于 2 号染色体上。可变剪接导致多个转录本变体。已经描述了该基因的其他可变剪接转录变体,但它们的全长性质尚不清楚。[RefSeq 提供,2014 年 7 月]

The protein encoded by this gene shares similarity with Saccharomyces cerevisiae Rad52, a protein important for DNA double-strand break repair and homologous recombination. This gene product was shown to bind single-stranded DNA ends, and mediate the DNA-DNA interaction necessary for the annealing of complementary DNA strands. It was also found to interact with DNA recombination protein RAD51, which suggested its role in RAD51 related DNA recombination and repair. A pseudogene of this gene is present on chromosome 2. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Jul 2014]

RAD52 基因产物(5)

mRNA Protein Name
NM_001297419.1 NP_001284348.1 DNA repair protein RAD52 homolog isoform a
NM_001297420.1 NP_001284349.1 DNA repair protein RAD52 homolog isoform b
NM_001297421.2 NP_001284350.1 DNA repair protein RAD52 homolog isoform c
NM_001297422.2 NP_001284351.1 DNA repair protein RAD52 homolog isoform d
NM_134424.4 NP_602296.2 DNA repair protein RAD52 homolog isoform a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA binding IDA
IDA: 通过直接分析推断
19506022 GOA
enables identical protein binding IPI
IPI: 通过物理相互作用推断
10744977 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
8702565 GOA
enables single-stranded DNA binding IMP
IMP: 通过突变表型推断
12370410 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
19506022 GOA
part of protein-DNA complex IMP
IMP: 通过突变表型推断
12370410 GOA
part of protein-containing complex IDA
IDA: 通过直接分析推断
19506022 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

RAD52 蛋白结构

Rad52_Rad22

Rad52_Rad22: Rad52/22 family double-strand break repair protein (35 - 180)

  • 0
  • 100
  • 200
  • 300
  • 418 a.a.
蛋白主名 其他名称

DNA repair protein RAD52 homolog

recombination protein RAD52

RAD52 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra RAD52 P43351 RDM1 Homo sapiens Q8NG50
Validated Y2H
32296183
Intra RAD52 P43351 RDM1 Homo sapiens Q8NG50
Y2H Prey Pooling
32296183
Intra RAD52 P43351 RDM1 Homo sapiens Q8NG50
Y2H Array
32296183
Intra RAD52 P43351 NFYC Homo sapiens Q13952-2
Validated Y2H
32296183
Intra RAD52 P43351 NFYC Homo sapiens Q13952-2
Y2H Prey Pooling
32296183
Intra RAD52 P43351 NFYC Homo sapiens Q13952-2
Y2H Array
32296183
Intra RAD52 P43351 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra RAD52 P43351 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra RAD52 P43351 MEOX2 Homo sapiens Q6FHY5
Validated Y2H
32296183
Intra RAD52 P43351 MEOX1 Homo sapiens P50221
Y2H Prey Pooling
32296183
Intra RAD52 P43351 MEOX1 Homo sapiens P50221
Validated Y2H
32296183
Intra RAD52 P43351 MEOX1 Homo sapiens P50221
Y2H Array
32296183
Intra RAD52 P43351 PAX5 Homo sapiens Q02548
Y2H Prey Pooling
32296183
Intra RAD52 P43351 PAX5 Homo sapiens Q02548
Validated Y2H
32296183
Intra RAD52 P43351 PAX5 Homo sapiens Q02548
Y2H Array
32296183
Intra RAD52 P43351 KPNA3 Homo sapiens O00505
Y2H Array
32296183
Intra RAD52 P43351 KPNA3 Homo sapiens O00505
Y2H Prey Pooling
32296183
Intra RAD52 P43351 WRN Homo sapiens Q14191
IF
12750383
Intra RAD52 P43351 WRN Homo sapiens Q14191
Anti Bait CoIP
12750383
Intra RAD52 P43351 WRN Homo sapiens Q14191
CoIP
12750383
Intra RAD52 P43351 DCP1A Homo sapiens Q9NPI6
Y2H Array
32296183
Intra RAD52 P43351 DCP1A Homo sapiens Q9NPI6
Y2H Prey Pooling
32296183
Intra RAD52 P43351 DCP1A Homo sapiens Q9NPI6
Validated Y2H
32296183
Intra RAD52 P43351 KPNA5 Homo sapiens O15131
Y2H Prey Pooling
32296183
Intra RAD52 P43351 KPNA5 Homo sapiens O15131
Y2H Array
32296183
Intra RAD52 P43351 RPA3 Homo sapiens P35244
Anti Tag CoIP
19338310
Intra RAD52 P43351 RAD52 Homo sapiens P43351
3D-EM-Tomo
10744977
Intra RAD52 P43351 RAD52 Homo sapiens P43351
BN-PAGE
21804533
Intra RAD52 P43351 RAD52 Homo sapiens P43351
Y2H
12750383
Intra RAD52 P43351 RAD52 Homo sapiens P43351
Validated Y2H
32296183
Intra RAD52 P43351 RAD52 Homo sapiens P43351
TEM
10744977
Intra RAD52 P43351 RAD52 Homo sapiens P43351
Y2H Prey Pooling
32296183
Intra RAD52 P43351 RAD52 Homo sapiens P43351
Y2H Array
32296183
Intra RAD52 P43351 PLK3 Homo sapiens Q9H4B4
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Non-Syndromic X-Linked Intellectual Disability 2

Mrx2

Werner Syndrome

Werner'S Syndrome

WRN

Adult Progeria

Ws

Adult Premature Ageing Syndrome

Adult Premature Aging Syndrome

Werners Syndrome

Short-Rib Thoracic Dysplasia 2 With Or Without Polydactyly

Asphyxiating Thoracic Dystrophy 2

SRTD2

Atd2

Jatd

Jeune Asphyxiating Thoracic Dystrophy

Jeune Syndrome 2

Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation

Xeroderma Pigmentosum, Variant Type

Xeroderma Pigmentosum

XPV

Xeroderma Pigmentosum Variant Type

Xeroderma Pigmentosum With Normal Dna Repair Rates

Photosensitivity With Defective Dna Synthesis

Xp

De Sanctis-Cacchione Syndrome

Desanctis-Cacchione Syndrome

Xeroderma Pigmentosa

Xerodermic Idiocy

Xeroderma Pigmentosum Variant

Xp - [Xeroderma Pigmentosum]

Atrophoderma Pigmentosum

Idiopathic Peripheral Autonomic Neuropathy
Rothmund-Thomson Syndrome, Type 2

Rothmund-Thomson Syndrome

Rts

RTS2

Poikiloderma Of Rothmund-Thomson

Rothmund-Thomson Syndrome Type 2

Congenital Poikiloderma

Poikiloderma Congenitale

Poikiloderma Atrophicans And Cataract

Poikiloderma Congenitale Of Rothmund-Thomson

Poikiloderma Of Rothmund-Thomson Type 2

Rothmund-Thomson Syndrome 2

Erythrokeratodermia Variabilis

Xeroderma Pigmentosum, Complementation Group G

Xeroderma Pigmentosum, Group G

Xeroderma Pigmentosum Vii

Xp7

XPG

Xeroderma Pigmentosum Group G

Xp Group G

Xp, Group G

Xpgc

Xeroderma Pigmentosum, Group G/Cockayne Syndrome

Xeroderma Pigmentosum, Type 7

Xeroderma Pigmentosum Complementation Group G

XP-G

Xp-G/Cs

Xeroderma Pigmentosum Group G/Cockayne Syndrome

Nijmegen Breakage Syndrome

Berlin Breakage Syndrome

NBS

Microcephaly, Normal Intelligence And Immunodeficiency

Ataxia-Telangiectasia Variant

Ataxia-Telangiectasia Variant V1

Seemanova Syndrome Ii

Immunodeficiency-Microcephaly-Chromosomal Instability Syndrome

Seemanova Syndrome Type 2

At-V1

Microcephaly With Normal Intelligence, Immunodeficiency, And Lymphoreticular Malignancies

Nonsyndromal Microcephaly, Autosomal Recessive, With Normal Intelligence

Immunodeficiency, Microcephaly, And Chromosomal Instability

Microcephaly-Immunodeficiency-Lymphoreticuloma Syndrome

Microcephaly Immunodeficiency Lymphoreticuloma

Microcephaly With Normal Intelligence Immunodeficiency And Lymphoreticular Malignancies

Nonsyndromal Microcephaly Autosomal Recessive With Normal Intelligence

Seemanova Syndrome 2

Ataxia-Telangiectasia Variant 1

Seemanova Syndrome

At V1

Ataxia-Telangiectasia, Variant 1

Microcephaly-Immunodeficiency-Lymphoid Malignancy Syndrome

V-At

Ataxia Telangiectasia Variant V1

Ovarian Cancer

Ovarian Carcinoma

Ovarian Neoplasm

Malignant Tumour Of Ovary

Cancer Of The Ovary

Epithelial Ovarian Cancer

Neoplasm Of Ovary

Ovarian Neoplasms

Ovarian Cancers

Malignant Neoplasm Of Ovary

Primary Malignant Neoplasm Of Ovary

Ovarian Cancer, Somatic

Malignant Ovarian Tumor

Ovary Neoplasm

Primary Ovarian Cancer

Tumor Of The Ovary

Malignant Neoplasm Of The Ovary

Malignant Tumor Of The Ovary

Ovarian Malignant Tumor

OC

Ovarian Carcinomas

Cancer, Ovarian

Cancer Of Ovary

Ovary Cancer

Ca Ovary

Hereditary Breast Ovarian Cancer Syndrome

Hereditary Breast And Ovarian Cancer Syndrome

Brca1- And Brca2-Associated Hereditary Breast And Ovarian Cancer

Breast And/Or Ovarian Cancer

Breast And Ovarian Cancer Syndrome

Hboc Syndrome

Hereditary Breast And Ovarian Cancer

Brca1- Brca2-Associated Hboc

Cockayne Syndrome B

Cockayne Syndrome Type 2

Cockayne Syndrome, Type B

Cockayne Syndrome Type Ii

CSB

Cockayne Syndrome 2

Cockayne Syndrome Type B

Ckn2

Cockayne Syndrome, Type Ii

Aplastic Anemia

Aplastic Anemia, Susceptibility To

Anemia Aplastic

Idiopathic Aplastic Anemia

Secondary Aplastic Anemia

Idiopathic Bone Marrow Failure

Aplastic Anemia Idiopathic

AA

Anemia, Aplastic

Aplastic Anemia, Idiopathic

Erythroid Aplasia

Aa - [Aplastic Anaemia]

Haematopoietic Aplasia

Aleukia Haemorrhagica

Anaemia Due To Decreased Red Cell Production

Aplasia Bone Marrow

Aplastic Bone Marrow

Hypoplastic Anaemia Nos

Myeloid Bone Marrow Aplasia

Pancytopenia

Panhaematopenia

Hypoproliferative Anaemia

Medullary Hypoplasia

Red Blood Cells Hypoplastic Anaemia

Panmyelophthisis

Panhemocytopenia

Refractive Hypoproliferative Anaemia

Toxic Anaemia

Toxic Aplastic Anaemia

Aplastic Anaemia Due To Toxic Cause

Idiopathic Aplastic Anaemia Nos

Trichothiodystrophy

Ttd

Amish Brittle Hair Syndrome

Bids Syndrome

Brittle Hair-Intellectual Impairment-Decreased Fertility-Short Stature Syndrome

Ibids

Pibids

Trichothiodystrophy Syndromes

Fanconi Anemia, Complementation Group A

Fanconi Anemia

Fanconi Pancytopenia

Fanconi Anemia Complementation Group A

FANCA

Fa

Fanconi Panmyelopathy

Fanconi'S Anemia

Fanconi Anaemia

Fanconi'S Anaemia

Fanconi Hypoplastic Anemia

Estren-Dameshek Variant Of Fanconi Anemia

Estren-Dameshek Variant Of Fanconi Pancytopenia

Fanconi Anemia Estren-Dameshek Variant

Fanconis Anemia

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus RAD52 RGD RGD:1304975
Canis familiaris RAD52 VGNC VGNC:45321
Bos taurus RAD52 VGNC VGNC:33688
Macaca mulatta RAD52 VGNC VGNC:97817
Mus musculus RAD52 MGD MGI:101949