1. Gene
  2. KPNA3 - karyopherin subunit alpha 3 Gene

KPNA3 - karyopherin subunit alpha 3 Gene

中文名称:核转运蛋白亚基 alpha 3

种属: Homo sapiens

同用名: SRP1; SRP4; IPOA4; SPG88; hSRP1; SRP1gamma

基因 ID: 3839 | 基因类型: protein coding

关于 KPNA3

Cytogenetic location: 13q14.2 Genomic coordinates (GRCh38): 13:49,699,320-49,792,682 (from NCBI)

This gene has 2 transcripts (splice variants), 232 orthologues, 6 paralogues and is associated with 1 phenotype. Ubiquitous expression in testis (RPKM 17.5), brain (RPKM 15.2) and 25 other tissues.

功能概要

真核细胞中分子在细胞核和细胞质之间的运输是由核孔复合体 (NPC) 介导的,它由 60-100 种蛋白质组成。小分子 (高达 70 kD) 可以通过非选择性扩散穿过核孔,而大分子则通过活性过程运输。该基因编码的蛋白属于 importin alpha 家族,参与核蛋白导入。[RefSeq 提供,2009 年 1 月]

The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC), which consists of 60-100 proteins. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion while larger molecules are transported by an active process. The protein encoded by this gene belongs to the importin alpha family, and is involved in nuclear protein import. [provided by RefSeq, Jan 2009]

KPNA3 基因产物(1)

mRNA Protein Name
NM_002267.4 NP_002258.2 importin subunit alpha-4
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
10523667 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of NLS-dependent protein nuclear import complex IPI
IPI: 通过物理相互作用推断
10523667 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

KPNA3 蛋白结构

IBB

IBB: Importin beta binding domain (4 - 93)

Arm

Arm: Armadillo/beta-catenin-like repeat (104 - 144)

Arm

Arm: Armadillo/beta-catenin-like repeat (147 - 184)

Arm

Arm: Armadillo/beta-catenin-like repeat (189 - 229)

Arm

Arm: Armadillo/beta-catenin-like repeat (233 - 271)

Arm

Arm: Armadillo/beta-catenin-like repeat (274 - 312)

Arm

Arm: Armadillo/beta-catenin-like repeat (315 - 355)

Arm

Arm: Armadillo/beta-catenin-like repeat (357 - 396)

Arm

Arm: Armadillo/beta-catenin-like repeat (402 - 438)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 521 a.a.
蛋白主名 其他名称

importin subunit alpha-4

SRP1-gamma

KPNA3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
KPNA3 O00505 CCDC102B Homo sapiens Q68D86 32296183
种属内
KPNA3 O00505 ApoL6 Homo sapiens B3KTP4 25416956
种属内
KPNA3 O00505 SLC5A11 Homo sapiens Q8WWX8 25416956
种属内
KPNA3 O00505 SLC5A11 Homo sapiens Q8WWX8 25416956
种属内
KPNA3 O00505 q9brl8_human Homo sapiens Q9BRL8 25416956
种属内
KPNA3 O00505 q9brl8_human Homo sapiens Q9BRL8 25416956
种属内
KPNA3 O00505 q9brl8_human Homo sapiens Q9BRL8 25416956
种属内
KPNA3 O00505 MAT2B Homo sapiens Q9NZL9 25416956
种属内
KPNA3 O00505 MAT2B Homo sapiens Q9NZL9 32296183
种属内
KPNA3 O00505 MAT2B Homo sapiens Q9NZL9 25416956
种属内
KPNA3 O00505 RPRD1A Homo sapiens Q96P16 25416956
种属内
KPNA3 O00505 UVSSA Homo sapiens Q2YD98 32296183
种属内
KPNA3 O00505 ERCC3 Homo sapiens P19447 32296183
种属内
KPNA3 O00505 ERCC3 Homo sapiens P19447
Y2H
21988832
种属内
KPNA3 O00505 TMEM276 Homo sapiens P0DTL5 32296183
种属内
KPNA3 O00505 ESR2 Homo sapiens Q92731-3 32296183
种属内
KPNA3 O00505 GRB10 Homo sapiens Q13322-4 32296183
种属内
KPNA3 O00505 L3MBTL4 Homo sapiens Q8NA19-2 32296183
种属内
KPNA3 O00505 BRD3 Homo sapiens Q15059-2 32296183
种属内
KPNA3 O00505 ANKRD11 Homo sapiens X5D778 32296183
种属内
KPNA3 O00505 NUP50 Homo sapiens Q9UKX7 32296183
种属内
KPNA3 O00505 NUP50 Homo sapiens Q9UKX7 25416956
种属内
KPNA3 O00505 NUP50 Homo sapiens Q9UKX7 25416956
种属内
KPNA3 O00505 TNIP3 Homo sapiens Q96KP6 32296183
种属内
KPNA3 O00505 KPNB1 Homo sapiens Q14974 35271311
种属内
KPNA3 O00505 HNRNPC Homo sapiens P07910 25416956
种属内
KPNA3 O00505 HNRNPC Homo sapiens P07910 25416956
种属内
KPNA3 O00505 NMNAT1 Homo sapiens Q9HAN9 32296183
种属内
KPNA3 O00505 KAT5 Homo sapiens Q92993 32296183
种属内
KPNA3 O00505 HTT Homo sapiens P42858 32814053
种属内
KPNA3 O00505 HTT Homo sapiens P42858
Y2H
17500595
种属内
KPNA3 O00505 HTT Homo sapiens P42858 32814053
种属内
KPNA3 O00505 HTT Homo sapiens P42858 32814053
种属内
KPNA3 O00505 POLR3C Homo sapiens Q9BUI4 32296183
种属内
KPNA3 O00505 HEXIM2 Homo sapiens Q96MH2 32296183
种属内
KPNA3 O00505 ZCCHC10 Homo sapiens Q8TBK6 25416956
种属内
KPNA3 O00505 ZCCHC10 Homo sapiens Q8TBK6 25416956
种属内
KPNA3 O00505 ZCCHC10 Homo sapiens Q8TBK6 25416956
种属内
KPNA3 O00505 FAM90A1 Homo sapiens Q86YD7 32296183
种属内
KPNA3 O00505 RAD52 Homo sapiens P43351 32296183
种属内
KPNA3 O00505 FTL Homo sapiens P02792 25416956
种属内
KPNA3 O00505 FTL Homo sapiens P02792 25416956
种属内
KPNA3 O00505 MAPK9 Homo sapiens P45984 32296183
种属内
KPNA3 O00505 MTA1 Homo sapiens Q13330 25416956
种属内
KPNA3 O00505 TSSC4 Homo sapiens Q9Y5U2 25416956
种属内
KPNA3 O00505 TSSC4 Homo sapiens Q9Y5U2 25416956
种属内
KPNA3 O00505 TSSC4 Homo sapiens Q9Y5U2 25416956
种属内
KPNA3 O00505 ZNF76 Homo sapiens P36508 32296183
种属内
KPNA3 O00505 BAHD1 Homo sapiens Q8TBE0 32296183
种属内
KPNA3 O00505 SPMIP9 Homo sapiens Q96LM6 25416956
种属内
KPNA3 O00505 SPMIP9 Homo sapiens Q96LM6 25416956
种属内
KPNA3 O00505 ZBTB24 Homo sapiens O43167 25416956
种属内
KPNA3 O00505 ZBTB24 Homo sapiens O43167 25416956
种属内
KPNA3 O00505 ZBTB24 Homo sapiens O43167 25416956
种属内
KPNA3 O00505 ATOSB Homo sapiens Q7L5A3 32296183
种属内
KPNA3 O00505 ZNF764 Homo sapiens Q96H86 32296183
种属内
KPNA3 O00505 ZCCHC12 Homo sapiens Q6PEW1 32296183
种属间
KPNA3 O00505 PB2 Influenza A virus P03427
SLC
23816991
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Spastic Paraplegia 37, Autosomal Dominant

SPG37

Autosomal Dominant Spastic Paraplegia Type 37

Hereditary Spastic Paraplegia 37

Autosomal Dominant Spastic Paraplegia 37

Influenza

Flu

Influenza With Non-Respiratory Manifestation

Influenza With Other Manifestations

Influenza, Human

Influenza, Susceptibility To

Seasonal Influenza, Virus Identified

Charcot-Marie-Tooth Disease, Axonal, Type 2dd

CMT2DD

Charcot-Marie-Tooth Neuropathy, Type 2dd

Charcot-Marie-Tooth Disease Type 2dd

Atp1a1-Related Autosomal Dominant Charcot-Marie-Tooth Disease Type 2

Atp1a1-Related Cmt2

Autosomal Dominant Charcot-Marie-Tooth Disease Type 2dd

Charcot-Marie-Tooth Disease 2dd

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Felis catus KPNA3 VGNC VGNC:67975
Rattus norvegicus KPNA3 RGD RGD:1311339
Canis familiaris KPNA3 VGNC VGNC:42501
Macaca mulatta KPNA3 VGNC VGNC:74200
Mus musculus KPNA3 MGD MGI:1100863
Bos taurus KPNA3 VGNC VGNC:30702