2. Gene
  3. MTA1 - metastasis associated 1 Gene

MTA1 - metastasis associated 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：转移相关 1

种属: Homo sapiens

基因 ID: 9112 | 基因类型: protein coding

关于 MTA1

Cytogenetic location: 14q32.33 Genomic coordinates (GRCh38): 14:105,419,827-105,470,729 (from NCBI)

This gene has 20 transcripts (splice variants), 207 orthologues and 5 paralogues. Ubiquitous expression in testis (RPKM 14.9), spleen (RPKM 9.4) and 25 other tissues.

功能概要

该基因编码一种蛋白质，该蛋白质在转移细胞 (特别是乳腺癌细胞系) 中表达的基因筛选中被识别出来。该基因的表达与至少两种类型的癌的转移潜能相关，尽管它也在许多正常组织中表达。它在转移中的作用尚不清楚。它最初被认为是核小体重塑脱乙酰酶复合物 NuRD 的 70kD 成分，但更可能的是该成分是一种不同但非常相似的蛋白质。不过，这两种蛋白质关系密切，以至于它们共享相同类型的结构域。这些结构域包括两个 DNA 结合结构域、一个二聚化结构域和一个常见于甲基化 DNA 的蛋白质中的结构域。该基因产物的概况和活性表明它参与调节转录，这可能通过染色质重塑来实现。已发现该基因的两个转录本变体编码不同的亚型。[RefSeq 提供，2011 年 2 月]

This gene encodes a protein that was identified in a screen for genes expressed in metastatic cells, specifically, mammary adenocarcinoma cell lines. Expression of this gene has been correlated with the metastatic potential of at least two types of carcinomas although it is also expressed in many normal tissues. The role it plays in metastasis is unclear. It was initially thought to be the 70kD component of a nucleosome remodeling deacetylase complex, NuRD, but it is more likely that this component is a different but very similar protein. These two proteins are so closely related, though, that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. The profile and activity of this gene product suggest that it is involved in regulating transcription and that this may be accomplished by chromatin remodeling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]

MTA1 基因产物(4)

mRNA Protein Name
NM_001203258.2 NP_001190187.1 metastasis-associated protein MTA1 isoform MTA1s
NM_001411061.1 NP_001397990.1 metastasis-associated protein MTA1 isoform 3
NM_001411062.1 NP_001397991.1 metastasis-associated protein MTA1 isoform 4
NM_004689.4 NP_004680.2 metastasis-associated protein MTA1 isoform MTA1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
21965678 GOA
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
IPI: 通过物理相互作用推断
22926524 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16511565 GOA
enables transcription coactivator activity IMP
IMP: 通过突变表型推断
21965678 GOA
enables transcription corepressor activity IMP
IMP: 通过突变表型推断
21965678 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in chromatin remodeling IDA
IDA: 通过直接分析推断
9790534 GOA
involved in double-strand break repair IMP
IMP: 通过突变表型推断
19805145 GOA
involved in negative regulation of gene expression, epigenetic IMP
IMP: 通过突变表型推断
24413532 GOA
involved in positive regulation of protein autoubiquitination IDA
IDA: 通过直接分析推断
19805145 GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process IMP
IMP: 通过突变表型推断
19805145 GOA
involved in response to ionizing radiation IDA
IDA: 通过直接分析推断
19805145 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of NuRD complex IDA
IDA: 通过直接分析推断
22926524 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
24970816 GOA
located in microtubule IDA
IDA: 通过直接分析推断
24970816 GOA
located in nuclear envelope IDA
IDA: 通过直接分析推断
24970816 GOA
located in nucleus IDA
IDA: 通过直接分析推断
21965678 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MTA1 蛋白结构

BAH

BAH: BAH domain (4 - 164)

ELM2

ELM2: ELM2 domain (167 - 220)

GATA

GATA: GATA zinc finger (393 - 429)

  • 0
  • 200
  • 400
  • 600
  • 715 a.a.
蛋白主名 其他名称

metastasis-associated protein MTA1

metastasis associated gene 1 protein

MTA1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra MTA1 Q13330 KRT40 Homo sapiens Q6A162
Y2H Array
31515488
Intra MTA1 Q13330 KRT40 Homo sapiens Q6A162
Y2H Prey Pooling
25416956
Intra MTA1 Q13330 KRTAP10-8 Homo sapiens P60410
Validated Y2H
25416956
Intra MTA1 Q13330 SH3GL1 Homo sapiens Q6FGM0
Y2H Prey Pooling
25416956
Intra MTA1 Q13330 SH3GL1 Homo sapiens Q6FGM0
Y2H Array
25416956
Intra MTA1 Q13330 MAGEA11 Homo sapiens P43364-2
Validated Y2H
25416956
Intra MTA1 Q13330 MAGEA11 Homo sapiens P43364-2
Y2H Array
25416956
Intra MTA1 Q13330 NOTCH2NLC Homo sapiens P0DPK4
Y2H Prey Pooling
32296183
Intra MTA1 Q13330 NOTCH2NLC Homo sapiens P0DPK4
Y2H Array
32296183
Intra MTA1 Q13330 HDAC2 Homo sapiens Q92769
Anti Tag CoIP
18451879
Intra MTA1 Q13330 HDAC2 Homo sapiens Q92769
Anti Tag CoIP
26028330
Intra MTA1 Q13330 HDAC1 Homo sapiens Q13547
Lumier
29997244
Intra MTA1 Q13330 HDAC1 Homo sapiens Q13547
Anti Bait CoIP
26028330
Intra MTA1 Q13330 HDAC1 Homo sapiens Q13547
Anti Bait CoIP
16511565
Intra MTA1 Q13330 HDAC1 Homo sapiens Q13547
CH-IP
26028330
Intra MTA1 Q13330 HDAC1 Homo sapiens Q13547
Anti Tag CoIP
18451879
Intra MTA1 Q13330 KPNA3 Homo sapiens O00505
Validated Y2H
25416956
Intra MTA1 Q13330 KPNA3 Homo sapiens O00505
Y2H Prey Pooling
25416956
Intra MTA1 Q13330 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
Intra MTA1 Q13330 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
Intra MTA1 Q13330 KPNA4 Homo sapiens O00629
Y2H Array
32296183
Intra MTA1 Q13330 KPNA4 Homo sapiens O00629
Y2H Prey Pooling
32296183
Intra MTA1 Q13330 HIF1A Homo sapiens Q16665
Anti Tag CoIP
16511565
Intra MTA1 Q13330 HIF1A Homo sapiens Q16665
Imaging
16511565
Intra MTA1 Q13330 HIF1A Homo sapiens Q16665
Anti Bait CoIP
16511565
Intra MTA1 Q13330 RBBP4 Homo sapiens Q09028
Y2H Prey Pooling
25416956
Intra MTA1 Q13330 RBBP4 Homo sapiens Q09028
Anti Tag CoIP
33961781
Intra MTA1 Q13330 SH3GL1 Homo sapiens Q99961
Validated Y2H
32296183
Intra MTA1 Q13330 SH3GL1 Homo sapiens Q99961
Y2H Array
32296183
Intra MTA1 Q13330 SH3GL1 Homo sapiens Q99961
Y2H Prey Pooling
32296183
Intra MTA1 Q13330 ZEB2 Homo sapiens O60315
Anti Tag CoIP
26028330
Intra MTA1 Q13330 ZEB2 Homo sapiens O60315
Pull Down
26028330
Intra MTA1 Q13330 ZEB2 Homo sapiens O60315
CH-IP
26028330
Intra MTA1 Q13330 LZTS2 Homo sapiens Q9BRK4
Validated Y2H
25416956
Intra MTA1 Q13330 KHDRBS2 Homo sapiens Q5VWX1
Y2H Array
25416956
Intra MTA1 Q13330 EHMT2 Homo sapiens Q96KQ7
Anti Bait CoIP
26028330
Intra MTA1 Q13330 EHMT2 Homo sapiens Q96KQ7
Pull Down
26028330
Intra MTA1 Q13330 EHMT2 Homo sapiens Q96KQ7
Anti Tag CoIP
26028330
Intra MTA1 Q13330 IKZF1 Homo sapiens Q13422
Validated Y2H
25416956
Intra MTA1 Q13330 PICK1 Homo sapiens Q9NRD5
Validated Y2H
32296183
Intra MTA1 Q13330 PICK1 Homo sapiens Q9NRD5
Y2H Array
32296183
Intra MTA1 Q13330 PICK1 Homo sapiens Q9NRD5
Y2H Prey Pooling
32296183
Intra MTA1 Q13330 JUN Homo sapiens P05412
Pull Down
21555589
Intra MTA1 Q13330 NOTCH2NLA Homo sapiens Q7Z3S9
Y2H Prey Pooling
25416956
Intra MTA1 Q13330 NOTCH2NLA Homo sapiens Q7Z3S9
Validated Y2H
25416956
Intra MTA1 Q13330 KRT31 Homo sapiens Q15323
Y2H Array
32296183
Intra MTA1 Q13330 KRT31 Homo sapiens Q15323
Validated Y2H
32296183
Intra MTA1 Q13330 KRT31 Homo sapiens Q15323
Y2H Prey Pooling
32296183
Intra MTA1 Q13330 PLEKHG4 Homo sapiens Q58EX7
Validated Y2H
32296183
Intra MTA1 Q13330 PLEKHG4 Homo sapiens Q58EX7
Y2H Prey Pooling
32296183
Intra MTA1 Q13330 PLEKHG4 Homo sapiens Q58EX7
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Microphthalmia, Isolated 1

Isolated Microphthalmia 1

MCOP1

Mcop

Anophthalmia, Clinical, Isolated

Microphthalmos, Autosomal Recessive
Adenocarcinoma

Adenocarcinomas

Adenoacanthoma Of Unspecified Site

Adenocarcinoid Of Unspecified Site

Adenocarcinoid Tumour Of Unspecified Site

Adenocarcinoma And Carcinoid Combined Of Unspecified Site

Adenocarcinoma Nos
Developmental And Epileptic Encephalopathy 44

DEE44

Epileptic Encephalopathy, Early Infantile, 44

Eiee44

Developmental And Epileptic Encephalopathy, 44

Early Infantile Epileptic Encephalopathy 44

Encephalopathy, Epileptic, Early Infantile, Type 44
Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation
Ovarian Cancer

Ovarian Carcinoma

Ovarian Neoplasm

Malignant Tumour Of Ovary

Cancer Of The Ovary

Epithelial Ovarian Cancer

Neoplasm Of Ovary

Ovarian Neoplasms

Ovarian Cancers

Malignant Neoplasm Of Ovary

Primary Malignant Neoplasm Of Ovary

Ovarian Cancer, Somatic

Malignant Ovarian Tumor

Ovary Neoplasm

Primary Ovarian Cancer

Tumor Of The Ovary

Malignant Neoplasm Of The Ovary

Malignant Tumor Of The Ovary

Ovarian Malignant Tumor

OC

Ovarian Carcinomas

Cancer, Ovarian

Cancer Of Ovary

Ovary Cancer

Ca Ovary
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon
Hutchinson-Gilford Progeria Syndrome

Progeria

HGPS

Hutchinson-Gilford Syndrome

Hutchinson-Gilford Progeria

Hutchinson Gilford Syndrome

Hutchinson Gilford Progeria Syndrome

Hutchinson-Gilford Disease

Progeria Of Childhood

Hutchinson-Gilford-Progeria Syndrome
Esophageal Cancer

Esophageal Carcinoma

Carcinoma Of Esophagus

Esophageal Squamous Cell Carcinoma, Somatic

Esophageal Carcinoma, Somatic

Esophagus Cancer

Gastric Cardia Adenocarcinoma

Esophageal Neoplasms

Esophageal Cancer, Somatic

Cancer Of Esophagus

Cancer Of Oesophagus

Carcinoma Of Oesophagus

Ca Lower Third Oesophagus

Ca Middle Third Oesophagus

Malignant Neoplasm Of Distal Third Of Esophagus

Malignant Neoplasm Of Lower Third Of Oesophagus

Malignant Neoplasm Of Middle Third Of Oesophagus

Malignant Neoplasm Of Proximal Third Of Esophagus

Malignant Neoplasm Of Upper Third Esophagus

Malignant Tumor Of Abdominal Esophagus

Malignant Tumor Of Distal Third Of Esophagus

Malignant Tumor Of Proximal Third Of Esophagus

Malignant Tumor Of The Middle Third Of The Esophagus

ESCR

Aerodigestive Tract Cancer

Escc

Esophageal Squamous Cell Carcinoma

Cancer, Esophageal

Malignant Neoplasm Of Esophagus

Squamous Cell Carcinoma Of Esophagus

Malignant Neoplasm Of Middle Third Of Esophagus
Hepatocellular Carcinoma

Liver Cancer

Primary Liver Cancer

HCC

Hepatoma

Malignant Neoplasm Of Liver

Liver Neoplasms

Cancer, Hepatocellular

Liver Cell Carcinoma

Lcc

Hepatoblastoma, Somatic

Hepatic Cancer

Primary Malignant Neoplasm Of Liver

Rare Tumor Of Liver And Intrahepatic Biliary Tract

Hepatocellular Carcinoma, Somatic

Hepatocellular Carcinoma, Childhood Type, Somatic

Hepatocellular Cancer, Somatic

Ca Liver - Primary

Hepatic Neoplasm

Malignant Hepato-Biliary Neoplasm

Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

Malignant Neoplasm Of Liver, Primary

Malignant Tumor Of Liver

Neoplasm Of Liver

Non-Resectable Primary Hepatic Malignant Neoplasm

Resectable Malignant Neoplasm Of Liver

Resectable Malignant Neoplasm Of The Liver

Primary Liver Carcinoma

Primary Malignant Liver Neoplasm

Primary Cancer Of Liver

Primary Tumor Of The Liver

Rare Tumor Of Liver And Ibt

Hepatocellular Cancer

Neoplasm Of The Liver

Carcinoma, Hepatocellular

Hepatomas

Liver Neoplasm

Liver Carcinoma

Liver And Intrahepatic Biliary Tract Carcinoma

Malignant Hepatobiliary Neoplasm

Adult Primary Hepatocellular Carcinoma

Hepatoblastoma

Carcinoma Of Liver

Malignant Liver Tumour

Malignant Hepatic Tumour
Pancreatic Cancer

Pancreatic Carcinoma

Carcinoma Of Pancreas

Familial Pancreatic Carcinoma

Pancreatic Neoplasm

Pancreatic Carcinoma, Familial

Malignant Neoplasm Of Pancreas

Pancreatic Acinar Carcinoma

Pancreatic Tumor

Familial Pancreatic Cancer

Neoplasm Of The Pancreas

Cancer Of The Pancreas

Pancreatic Carcinoma, Somatic

Pancreatic Cancer, Somatic

Ca Body Of Pancreas

Ca Head Of Pancreas

Ca Tail Of Pancreas

Malignant Neoplasm Of Body Of Pancreas

Malignant Neoplasm Of Head Of Pancreas

Malignant Neoplasm Of Tail Of Pancreas

Pancreas Neoplasm

Exocrine Cancer

Exocrine Pancreas Carcinoma

Hereditary Pancreatic Cancer

Hereditary Pancreatic Carcinoma

PNCA

Pancreatic Cancer, Susceptibility To

Carcinoma Of Head Of Pancreas

Pancreatic Neoplasms

Pancreatic Tumors

Cancer, Pancreatic

Cancer Of Pancreas

Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS08746 MTA1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus MTA1 VGNC VGNC:68334
Rattus norvegicus MTA1 RGD RGD:621018
Macaca mulatta MTA1 VGNC VGNC:74942
Mus musculus MTA1 MGD MGI:2150037
Canis familiaris MTA1 VGNC VGNC:43456
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