HNRNPC - heterogeneous nuclear ribonucleoprotein C Gene

中文名称：异质核核糖核蛋白 C

种属: Homo sapiens

同用名: C1; C2; HNRNP; HNRPC; SNRPC

基因 ID: 3183 | 基因类型: protein coding

关于 HNRNPC

Cytogenetic location: 14q11.2 Genomic coordinates (GRCh38): 14:21,209,147-21,269,442 (from NCBI)

This gene has 32 transcripts (splice variants), 97 orthologues and 6 paralogues. Ubiquitous expression in lymph node (RPKM 82.0), bone marrow (RPKM 78.3) and 25 other tissues.

功能概要

该基因属于普遍表达的异质核核糖核蛋白 (hnRNP) 亚家族。 hnRNPs 是 RNA 结合蛋白，它们与异质核 RNA (hnRNA) 复合。这些蛋白质与细胞核中的前体 mRNA 相关，并且似乎影响前体 mRNA 加工以及 mRNA 代谢和运输的其他方面。虽然所有的 hnRNP 都存在于细胞核中，但有些似乎在细胞核和细胞质之间穿梭。 hnRNP 蛋白具有独特的核酸结合特性。该基因编码的蛋白质可以作为四聚体，参与 40S hnRNP 颗粒的组装。已经为该基因描述了编码至少两种不同亚型的多个转录物变体。[RefSeq 提供，2008 年 7 月]

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and Other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene can act as a tetramer and is involved in the assembly of 40S hnRNP particles. Multiple transcript variants encoding at least two different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

HNRNPC 基因产物(4)

mRNA	Protein	Name
NM_001077442.2	NP_001070910.1	heterogeneous nuclear ribonucleoproteins C1/C2 isoform a
NM_001077443.2	NP_001070911.1	heterogeneous nuclear ribonucleoproteins C1/C2 isoform b
NM_004500.4	NP_004491.2	heterogeneous nuclear ribonucleoproteins C1/C2 isoform b
NM_031314.3	NP_112604.2	heterogeneous nuclear ribonucleoproteins C1/C2 isoform a

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables N6-methyladenosine-containing RNA reader activity	IDA IDA: 通过直接分析推断	25719671	GOA
enables RNA binding	IPI IPI: 通过物理相互作用推断	18082603	GOA
enables identical protein binding	IPI IPI: 通过物理相互作用推断	16189514	GOA
enables mRNA 3'-UTR binding	IDA IDA: 通过直接分析推断	16010978	GOA
enables poly(U) RNA binding	IDA IDA: 通过直接分析推断	16010978	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	11546873	GOA
enables telomerase RNA binding	IPI IPI: 通过物理相互作用推断	18082603	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in 3'-UTR-mediated mRNA stabilization	IMP IMP: 通过突变表型推断	16010978	GOA
involved in mRNA splicing, via spliceosome	IMP IMP: 通过突变表型推断	25719671	GOA
involved in negative regulation of telomere maintenance via telomerase	IMP IMP: 通过突变表型推断	18082603	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in actin cytoskeleton	IDA IDA: 通过直接分析推断	11687588	GOA
part of catalytic step 2 spliceosome	IDA IDA: 通过直接分析推断	11991638	GOA
located in cytosol	IDA IDA: 通过直接分析推断	16010978	GOA
located in nucleus	IDA IDA: 通过直接分析推断	11687588	GOA
part of protein-containing complex	IDA IDA: 通过直接分析推断	11687588	GOA
part of spliceosomal complex	IDA IDA: 通过直接分析推断	9731529	GOA
part of telomerase holoenzyme complex	IDA IDA: 通过直接分析推断	18082603	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

HNRNPC 蛋白结构

RRM_1

0
100
200
306 a.a.

蛋白主名

其他名称

heterogeneous nuclear ribonucleoproteins C1/C2

heterogeneous nuclear ribonucleoprotein C (C1/C2)

HNRNPC 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	HNRNPC	P07910	SUMO1P1	Homo sapiens	G2XKQ0	Y2H Prey Pooling	25416956
种属内	HNRNPC	P07910	SUMO1P1	Homo sapiens	G2XKQ0	Validated Y2H	25416956
种属内	HNRNPC	P07910	UBE2I	Homo sapiens	Q7KZS0	Y2H Prey Pooling	25416956
种属内	HNRNPC	P07910	HNRNPCL1	Homo sapiens	O60812	Anti Tag CoIP	33961781
种属内	HNRNPC	P07910	HNRNPCL1	Homo sapiens	O60812	Y2H Prey Pooling	32296183
种属内	HNRNPC	P07910	HNRNPCL1	Homo sapiens	O60812	Y2H Array	32296183
种属内	HNRNPC	P07910	RALYL	Homo sapiens	Q86SE5-3	Validated Y2H	32296183
种属内	HNRNPC	P07910	RALYL	Homo sapiens	Q86SE5-3	Y2H Array	32296183
种属内	HNRNPC	P07910	RALYL	Homo sapiens	Q86SE5-3	Y2H Prey Pooling	32296183
种属内	HNRNPC	P07910	RBPMS2	Homo sapiens	Q6ZRY4	Validated Y2H	32296183
种属内	HNRNPC	P07910	RBPMS2	Homo sapiens	Q6ZRY4	Y2H Array	32296183
种属内	HNRNPC	P07910	RBPMS2	Homo sapiens	Q6ZRY4	Y2H Prey Pooling	32296183
种属内	HNRNPC	P07910	DISC1	Homo sapiens	Q9NRI5-2	Y2H Prey Pooling	32296183
种属内	HNRNPC	P07910	DISC1	Homo sapiens	Q9NRI5-2	Validated Y2H	32296183
种属内	HNRNPC	P07910	DISC1	Homo sapiens	Q9NRI5-2	Y2H Array	32296183
种属内	HNRNPC	P07910	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
种属内	HNRNPC	P07910	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
种属内	HNRNPC	P07910	MEOX2	Homo sapiens	Q6FHY5	Validated Y2H	32296183
种属内	HNRNPC	P07910	SHANK3	Homo sapiens	Q9BYB0	Anti Tag CoIP	21653829
种属内	HNRNPC	P07910	SHANK3	Homo sapiens	Q9BYB0	Y2H Pooling	21653829
种属内	HNRNPC	P07910	RNF4	Homo sapiens	P78317	Y2H Prey Pooling	32296183
种属内	HNRNPC	P07910	RNF4	Homo sapiens	P78317	Validated Y2H	32296183
种属内	HNRNPC	P07910	RNF4	Homo sapiens	P78317	Y2H Array	32296183
种属内	HNRNPC	P07910	HNRNPA2B1	Homo sapiens	P22626	Crosslink	30021884
种属内	HNRNPC	P07910	HNRNPA2B1	Homo sapiens	P22626	Anti Tag CoIP	35271311
种属内	HNRNPC	P07910	HNRNPD	Homo sapiens	Q14103	Anti Tag CoIP	35271311
种属内	HNRNPC	P07910	YWHAZ	Homo sapiens	P63104	Pull Down	15161933
种属内	HNRNPC	P07910	KPNA2	Homo sapiens	P52292	Y2H Array	25416956
种属内	HNRNPC	P07910	HNRNPA1	Homo sapiens	P09651	Anti Tag CoIP	35271311
种属内	HNRNPC	P07910	HNRNPA1	Homo sapiens	P09651	Crosslink	30021884
种属内	HNRNPC	P07910	HNRNPA1	Homo sapiens	P09651	Anti Bait CoIP	11546873
种属内	HNRNPC	P07910	HNRNPC	Homo sapiens	P07910	Y2H Pooling	16189514
种属内	HNRNPC	P07910	HNRNPC	Homo sapiens	P07910	Validated Y2H	32296183
种属内	HNRNPC	P07910	HNRNPC	Homo sapiens	P07910	Y2H Array	25416956
种属内	HNRNPC	P07910	KPNA4	Homo sapiens	O00629	Anti Tag CoIP	35271311
种属内	HNRNPC	P07910	KPNA4	Homo sapiens	O00629	Y2H Array	32296183
种属内	HNRNPC	P07910	KPNA4	Homo sapiens	O00629	FPS	35044719
种属内	HNRNPC	P07910	KPNA3	Homo sapiens	O00505	Y2H Prey Pooling	25416956
种属内	HNRNPC	P07910	HNRNPC	Homo sapiens	P07910	Pull Down	16189514
种属内	HNRNPC	P07910	HNRNPC	Homo sapiens	P07910	Y2H Array	32296183
种属内	HNRNPC	P07910	KPNA3	Homo sapiens	O00505	Anti Tag CoIP	35271311
种属内	HNRNPC	P07910	HNRNPC	Homo sapiens	P07910	Y2H	22365833
种属内	HNRNPC	P07910	HNRNPC	Homo sapiens	P07910	Y2H Prey Pooling	32296183
种属内	HNRNPC	P07910	KPNA4	Homo sapiens	O00629	Validated Y2H	25416956
种属内	HNRNPC	P07910	KPNA4	Homo sapiens	O00629	Y2H Prey Pooling	32296183
种属内	HNRNPC	P07910	KPNA3	Homo sapiens	O00505	Y2H Pooling	16189514
种属内	HNRNPC	P07910	KPNA3	Homo sapiens	O00505	Y2H Pooling	19447967
种属内	HNRNPC	P07910	HNRNPC	Homo sapiens	P07910	Y2H	21516116
种属内	HNRNPC	P07910	TARDBP	Homo sapiens	Q13148	Y2H Pooling	32814053
种属内	HNRNPC	P07910	TARDBP	Homo sapiens	Q13148	Validated Y2H	32814053
种属内	HNRNPC	P07910	TARDBP	Homo sapiens	Q13148	Y2H Array	32814053
种属内	HNRNPC	P07910	CDC5L	Homo sapiens	Q99459	Anti Tag CoIP	33961781
种属内	HNRNPC	P07910	EPS8	Homo sapiens	Q12929	Y2H Prey Pooling	25416956
种属内	HNRNPC	P07910	HTT	Homo sapiens	P42858	Y2H Array	32814053
种属内	HNRNPC	P07910	HTT	Homo sapiens	P42858	Pull Down	17500595
种属内	HNRNPC	P07910	HTT	Homo sapiens	P42858	Y2H Pooling	32814053
种属内	HNRNPC	P07910	HTT	Homo sapiens	P42858	Validated Y2H	32814053
种属内	HNRNPC	P07910	KPNA5	Homo sapiens	O15131	Y2H Array	32296183
种属内	HNRNPC	P07910	KPNA5	Homo sapiens	O15131	Y2H Prey Pooling	32296183
种属内	HNRNPC	P07910	SRPK2	Homo sapiens	P78362	Protein Kinase Assay	23602568
种属内	HNRNPC	P07910	RALY	Homo sapiens	Q9UKM9	Anti Tag CoIP	33961781
种属内	HNRNPC	P07910	SDCBP	Homo sapiens	O00560	Y2H Array	32296183
种属内	HNRNPC	P07910	SDCBP	Homo sapiens	O00560	Y2H Prey Pooling	25416956
种属内	HNRNPC	P07910	SDCBP	Homo sapiens	O00560	Y2H Prey Pooling	32296183
种属内	HNRNPC	P07910	LMO2	Homo sapiens	P25791	Y2H Array	25416956
种属内	HNRNPC	P07910	RBM41	Homo sapiens	Q96IZ5	Y2H Pooling	16189514
种属内	HNRNPC	P07910	RBM41	Homo sapiens	Q96IZ5	Y2H Array	25416956
种属内	HNRNPC	P07910	RBM41	Homo sapiens	Q96IZ5	Y2H	21516116
种属内	HNRNPC	P07910	RALYL	Homo sapiens	Q86SE5	Validated Y2H	25416956
种属内	HNRNPC	P07910	RALYL	Homo sapiens	Q86SE5	Y2H Pooling	19447967
种属内	HNRNPC	P07910	RALYL	Homo sapiens	Q86SE5	Y2H Prey Pooling	25416956
种属内	HNRNPC	P07910	RALYL	Homo sapiens	Q86SE5	Y2H Array	25416956
种属内	HNRNPC	P07910	RALYL	Homo sapiens	Q86SE5	Y2H Pooling	16189514
种属内	HNRNPC	P07910	PAX6	Homo sapiens	P26367	Y2H Prey Pooling	32296183
种属内	HNRNPC	P07910	PAX6	Homo sapiens	P26367	Validated Y2H	32296183
种属内	HNRNPC	P07910	PAX6	Homo sapiens	P26367	Y2H Array	32296183
种属内	HNRNPC	P07910	SUMO1	Homo sapiens	P63165	Validated Y2H	25416956
种属内	HNRNPC	P07910	SUMO1	Homo sapiens	P63165	Y2H Prey Pooling	32296183
种属内	HNRNPC	P07910	SUMO1	Homo sapiens	P63165	Validated Y2H	32296183
种属内	HNRNPC	P07910	SUMO1	Homo sapiens	P63165	Y2H Array	32296183
种属内	HNRNPC	P07910	ZFYVE26	Homo sapiens	Q68DK2-5	Y2H Array	25416956
种属内	HNRNPC	P07910	ZFYVE26	Homo sapiens	Q68DK2-5	Validated Y2H	25416956
种属内	HNRNPC	P07910	HNRNPCL2	Homo sapiens	B2RXH8	Y2H Array	32296183
种属内	HNRNPC	P07910	HNRNPCL2	Homo sapiens	B2RXH8	Y2H Prey Pooling	32296183
种属内	HNRNPC	P07910	RALY	Homo sapiens	Q53GL6	Validated Y2H	32296183
种属内	HNRNPC	P07910	RALY	Homo sapiens	Q53GL6	Y2H Array	32296183
种属内	HNRNPC	P07910	RALY	Homo sapiens	Q53GL6	Y2H Prey Pooling	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

HNRNPC 抗体

目录号	产品名	应用	反应物种
HY-P82129	hnRNP C1/C2 Antibody (YA1874)	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse, Rat

关联疾病

疾病名称

别名

Mixed Connective Tissue Disease

Sharp Syndrome	Mctd
Connective Tissue Disease Overlap Syndrome	Mixed Collagen Vascular Disease
Mctd - [Mixed Connective Tissue Disease]

Oculopharyngeal Muscular Dystrophy

OPMD	Muscular Dystrophy, Oculopharyngeal
Dystrophy, Oculopharyngeal Muscular	Oculopharyngeal Dystrophy
Progressive Muscular Dystrophy, Oculopharyngeal Type	Muscular Dystrophy Oculopharyngeal
Dystrophy, Muscular, Oculopharyngeal

Connective Tissue Disease

Connective Tissue Diseases	Connective Tissue Disorder
Abnormality Of Connective Tissue	Disorder Of Connective Tissue
Connective Tissue Disorders

Multisystem Proteinopathy

Muscular Atrophy

Muscle Wasting	Amyotrophia
Wasting - Muscle	Skeletal Muscle Atrophy

Fragile X-Associated Tremor/Ataxia Syndrome

Fxtas Syndrome	Fragile X Tremor/Ataxia Syndrome
Fxtas

Muscular Dystrophy

Muscular Dystrophies	Congenital Md
Congenital Muscular Dystrophy	Cmd
Mdc	Dystrophy, Muscular
Gower'S Muscular Dystrophy	Progressive Musclular Dystrophy
Pseudohypertrophic Atrophy	Pseudohypertrophic Muscle Paralysis
Pseudohypertrophic Muscular Atrophy	Pseudohypertrophic Muscular Dystrophy
Pseudohypertrophic Paralysis	Pseudomuscular Hypertrophy

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 1

FTDALS1	Frontotemporal Dementia And/Or Motor Neuron Disease
Ftdmnd	Amyotrophic Lateral Sclerosis And/Or Frontotemporal Dementia
Alsftd	Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis
Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis-1	Frontotemporal Dementia With Motor Neuron Disease
Ftdals	Ftd-Als
Ftd-Mnd	Frontotemporal Dementia With Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis With Frontotemporal Dementia 1	Amyotrophic Lateral Sclerosis/Frontotemporal Dementia
Dementia, Frontotemporal, And/Or Amyotrophic Lateral Sclerosis	Amyotrophic Lateral Sclerosis And/Or Frontotemporal Dementia 1
Frontotemporal Lobar Degeneration	Grn-Related Frontotemporal Dementia

Frontotemporal Dementia

Pallidopontonigral Degeneration	Frontotemporal Lobar Degeneration
Semantic Dementia	FTD
Frontotemporal Lobe Dementia	Multiple System Tauopathy With Presenile Dementia
Dementia, Frontotemporal	Frontotemporal Dementia With Parkinsonism
Mstd	Frontotemporal Lobar Degeneration With Tau Inclusions
Ftld With Tau Inclusions	Dementia, Frontotemporal, With Parkinsonism
Fldem	Ftdp17
Disinhibition-Dementia-Parkinsonism-Amyotrophy Complex	Ddpac
Wilhelmsen-Lynch Disease	Wld
Ppnd	Dementia, Frontotemporal, With Or Without Parkinsonism
Semantic Primary Progressive Aphasia	Semantic Variant Ppa
Wilhemsen-Lynch Disease	Frontotemporal Dementia-Amyotrophic Lateral Sclerosis
Frontotemporal Dementia And Parkinsonism Linked To Chromosome 17	Ftd-Als
Ftld	Pick Complex
Pick Disease Of The Brain	Frontotemporal Dementia With Parkinsonism-17
Grn-Related Frontotemporal Dementia	Frontotemporal Dementia With Motor Neuron Disease
Dementia In Fronto-Temporal Lobar Degeneration	Ftd - [Frontotemporal Dementia]
Temple Dementia	Frontal Lobe Dementia

Wilms Tumor 1

Nephroblastoma	Wilms Tumor
WT1	Wilms' Tumor
Bilateral Wilms Tumor	Wilms Tumor, Type 1
Wilms Tumor, Somatic	Adult Nephroblastoma
Wt1 Disorder	Renal Embryonic Tumor
Adult Kidney Wilms Tumor	Childhood Kidney Wilms Tumor
Nonanaplastic Kidney Wilms Tumor

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis	ALS
Lou Gehrig Disease	Amyotrophic Lateral Sclerosis Type 1
Charcot Disease	ALS1
Amyotrophic Lateral Sclerosis, Susceptibility To	Fals
Lou Gehrig'S Disease	Mnd
Motor Neuron Disease	Familial Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 1, Familial	Amyotrophic Lateral Sclerosis 1, Autosomal Dominant
Motor Neuron Disease, Bulbar	Motor Neurone Disease
Amyotrophic Lateral Sclerosis With Dementia	Dementia With Amyotrophic Lateral Sclerosis
Motor Neuron Disease, Amyotrophic Lateral Sclerosis	Sclerosis, Lateral, Amyotrophic
Sclerosis, Lateral, Amyotrophic, Type 1	Amyotrophic Sclerosis
Als - [Amyotrophic Lateral Sclerosis]	Wasting Palsy
Amyotrophic Paralysis	Amyotrophy Lateral Sclerosis
Wasting Paralysis	Spinal Progressive Amyotrophy
Progressive Atrophic Paralysis

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS06265	HNRNPC Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	HNRNPC	RGD	RGD:1309982
Mus musculus	HNRNPC	MGD	MGI:107795
Macaca mulatta	HNRNPC	VGNC	VGNC:84348

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