EPS8 - epidermal growth factor receptor pathway substrate 8 Gene

中文名称：表皮生长因子受体通路底物 8

种属: Homo sapiens

同用名: DFNB102

基因 ID: 2059 | 基因类型: protein coding

关于 EPS8

Cytogenetic location: 12p12.3 Genomic coordinates (GRCh38): 12:15,620,134-15,789,388 (from NCBI)

This gene has 27 transcripts (splice variants), 220 orthologues, 3 paralogues and is associated with 1 phenotype. Ubiquitous expression in gall bladder (RPKM 34.8), fat (RPKM 34.0) and 24 other tissues.

功能概要

该基因编码 EPS8 家族的一个成员。该蛋白包含一个 PH 结构域和一个 SH3 结构域。它作为 EGFR 通路的一部分发挥作用，但其确切作用尚未确定。其他生物体中高度相似的蛋白质参与从 Ras 到 Rac 的信号转导和生长因子介导的肌动蛋白重塑。已观察到该基因的替代转录剪接变体，但尚未彻底表征。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the EPS8 family. This protein contains one PH domain and one SH3 domain. It functions as part of the EGFR pathway, though its exact role has not been determined. Highly similar proteins in Other organisms are involved in the transduction of signals from Ras to Rac and growth factor-mediated actin remodeling. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]

EPS8 基因产物(11)

mRNA	Protein	Name
NM_001413831.1	NP_001400760.1	epidermal growth factor receptor kinase substrate 8 isoform a
NM_001413832.1	NP_001400761.1	epidermal growth factor receptor kinase substrate 8 isoform b
NM_001413833.1	NP_001400762.1	epidermal growth factor receptor kinase substrate 8 isoform b
NM_001413834.1	NP_001400763.1	epidermal growth factor receptor kinase substrate 8 isoform b
NM_001413835.1	NP_001400764.1	epidermal growth factor receptor kinase substrate 8 isoform c
NM_001413836.1	NP_001400765.1	epidermal growth factor receptor kinase substrate 8 isoform c
NM_001413837.1	NP_001400766.1	epidermal growth factor receptor kinase substrate 8 isoform d
NM_001413838.1	NP_001400767.1	epidermal growth factor receptor kinase substrate 8 isoform e
NM_001413839.1	NP_001400768.1	epidermal growth factor receptor kinase substrate 8 isoform f
NM_001413840.1	NP_001400769.1	epidermal growth factor receptor kinase substrate 8 isoform g
NM_004447.6	NP_004438.3	epidermal growth factor receptor kinase substrate 8 isoform b

基因本体论

分子功能

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	15289329	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

EPS8 蛋白结构

PTB

SH3_1

0
200
400
600
822 a.a.

蛋白主名

其他名称

epidermal growth factor receptor kinase substrate 8

EPS8 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	EPS8	Q12929	GOLGA8DP	Homo sapiens	Q0D2H9	Y2H Prey Pooling	25416956
Intra	EPS8	Q12929	BORCS6	Homo sapiens	Q96GS4	Y2H Array	25416956
Intra	EPS8	Q12929	BORCS6	Homo sapiens	Q96GS4	Y2H Prey Pooling	25416956
Intra	EPS8	Q12929	RUNX1T1	Homo sapiens	Q06455-4	Validated Y2H	25416956
Intra	EPS8	Q12929	RUNX1T1	Homo sapiens	Q06455-4	Y2H Array	25416956
Intra	EPS8	Q12929	INPP5J	Homo sapiens	Q15735	Y2H Array	25416956
Intra	EPS8	Q12929	INPP5J	Homo sapiens	Q15735	Validated Y2H	25416956
Intra	EPS8	Q12929	INPP5J	Homo sapiens	Q15735	Y2H Prey Pooling	25416956
Intra	EPS8	Q12929	EGFR	Homo sapiens	P00533	Ub Reconstruction	24658140
Intra	EPS8	Q12929	HNRNPC	Homo sapiens	P07910	Validated Y2H	25416956
Intra	EPS8	Q12929	HNRNPC	Homo sapiens	P07910	Y2H Array	25416956
Intra	EPS8	Q12929	BYSL	Homo sapiens	Q13895	Y2H Array	25416956
Intra	EPS8	Q12929	BYSL	Homo sapiens	Q13895	Validated Y2H	25416956
Intra	EPS8	Q12929	GRB2	Homo sapiens	P62993	Validated Y2H	25416956
Intra	EPS8	Q12929	SMARCE1	Homo sapiens	Q969G3	Validated Y2H	25416956
Intra	EPS8	Q12929	SMARCE1	Homo sapiens	Q969G3	Y2H Array	25416956
Intra	EPS8	Q12929	SMARCE1	Homo sapiens	Q969G3	Y2H Prey Pooling	25416956
Intra	EPS8	Q12929	BAIAP2	Homo sapiens	Q9UQB8	Anti Bait CoIP	19564905
Intra	EPS8	Q12929	BAIAP2	Homo sapiens	Q9UQB8	Pull Down	15289329
Intra	EPS8	Q12929	BAIAP2	Homo sapiens	Q9UQB8	Validated Y2H	25416956
Intra	EPS8	Q12929	BAIAP2	Homo sapiens	Q9UQB8	Anti Tag CoIP	33961781
Intra	EPS8	Q12929	BAIAP2	Homo sapiens	Q9UQB8	Y2H Pooling	16189514
Intra	EPS8	Q12929	BAIAP2	Homo sapiens	Q9UQB8	Y2H Array	25416956
Intra	EPS8	Q12929	BAIAP2	Homo sapiens	Q9UQB8	Y2H Prey Pooling	25416956
Intra	EPS8	Q12929	BAIAP2	Homo sapiens	Q9UQB8-4	Anti Bait CoIP	24076653
Intra	EPS8	Q12929	ALDH7A1	Homo sapiens	P49419	Pull Down	21988832
Intra	EPS8	Q12929	C19orf25	Homo sapiens	Q9UFG5	Y2H Array	25416956

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Deafness, Autosomal Recessive 102

DFNB102	Autosomal Recessive Nonsyndromic Deafness 102
Autosomal Recessive Deafness 102	Deafness, Autosomal Recessive, 102
Deafness, Autosomal Recessive, Type 102

Autosomal Recessive Non-Syndromic Sensorineural Deafness Type Dfnb

Autosomal Recessive Isolated Neurosensory Deafness Type Dfnb	Autosomal Recessive Isolated Neurosensory Hearing Loss Type Dfnb
Autosomal Recessive Isolated Sensorineural Deafness Type Dfnb	Autosomal Recessive Isolated Sensorineural Hearing Loss Type Dfnb
Autosomal Recessive Non-Syndromic Neurosensory Deafness Type Dfnb	Autosomal Recessive Non-Syndromic Neurosensory Hearing Loss Type Dfnb
Autosomal Recessive Non-Syndromic Sensorineural Hearing Loss Type Dfnb

Autosomal Recessive Nonsyndromic Deafness

Deafness, Autosomal Recessive, Nonsyndromic

Deafness, Autosomal Recessive

Usher Syndrome, Type I

USH1	Usher Syndrome Type 1
Us1	Usher Syndrome, Type 1b
Usher Syndrome Type 1e	Retinitis Pigmentosa And Congenital Deafness
Usher Syndrome, Type Ie	USH1E
Usher Syndrome, Type 1e	Usher Syndrome, Type 1a
Usher Syndrome, Type Ib	Usher Syndrome Type 1b
Usher Syndrome Type Ie	Usher Syndrome Type I
Usher 1	Usher Syndrome, Type 1
Ush1a	Usher Syndrome, Type I, French Variety
Usher Syndrome, Type Ia	Usher Syndrome 1b
USH1B	Usher'S Syndrome Type 1b
Usher Syndrome Type Ib	Ushib

Autosomal Recessive Nonsyndromic Deafness 3

Autosomal Recessive Deafness 3, Neurosensory Nonsyndromic Recessive Deafness 3	Dfnb3
Nrsd3	Deafness, Autosomal Recessive 3

Usher Syndrome

Deafness-Retinitis Pigmentosa Syndrome	Dystrophia Retinae Pigmentosa-Dysostosis Syndrome
Graefe-Usher Syndrome	Hallgren Syndrome
Usher'S Syndrome	Retinitis Pigmentosa-Deafness Syndrome
Retinitis Pigmentosa-Hearing Loss Syndrome	Ush
Usher Syndromes

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS04454	EPS8 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS04455	EPS8L1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS04456	EPS8L2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS04457	EPS8L3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	EPS8	VGNC	VGNC:28555
Mus musculus	EPS8	MGD	MGI:104684
Macaca mulatta	EPS8	VGNC	VGNC:72249
Canis familiaris	EPS8	VGNC	VGNC:40427
Felis catus	EPS8	VGNC	VGNC:61920
Rattus norvegicus	EPS8	RGD	RGD:1310590

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

EPS8 - epidermal growth factor receptor pathway substrate 8 Gene

关于 EPS8

功能概要

EPS8 基因产物(11)

EPS8 蛋白结构

EPS8 蛋白互作信息

关联疾病

直系同源

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EPS8 - epidermal growth factor receptor pathway substrate 8 Gene

关于 EPS8

功能概要

EPS8 基因产物(11)

EPS8 蛋白结构

EPS8 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z