BAIAP2 - BAR/IMD domain containing adaptor protein 2 Gene

中文名称：含 BAR/IMD 结构域的衔接蛋白 2

种属: Homo sapiens

同用名: BAP2; WAML; FLAF3; IRSP53

基因 ID: 10458 | 基因类型: protein coding

关于 BAIAP2

Cytogenetic location: 17q25.3 Genomic coordinates (GRCh38): 17:81,035,151-81,117,434 (from NCBI)

This gene has 30 transcripts (splice variants), 282 orthologues and 2 paralogues. Broad expression in brain (RPKM 10.7), skin (RPKM 9.8) and 23 other tissues.

功能概要

由该基因编码的蛋白质已被鉴定为脑特异性血管生成抑制剂 (BAI1) 结合蛋白。这种衔接蛋白将膜结合 G 蛋白连接到细胞质效应蛋白。这种蛋白质作为胰岛素受体酪氨酸激酶底物发挥作用，表明胰岛素在中枢神经系统中发挥作用。它还与 Rho 小 G 蛋白的下游效应子有关，后者与应激纤维的形成和胞质分裂有关。这种蛋白质参与运动细胞中的片状伪足和丝状伪足的形成，并可能影响神经元生长锥的引导。这种蛋白质也被确定为与 dentatorubral-pallidoluysian 萎缩基因相互作用，该基因与常染色体显性神经退行性疾病有关。可变剪接导致编码不同异构体的多个转录变体。[RefSeq 提供，2009 年 1 月]

The protein encoded by this gene has been identified as a brain-specific angiogenesis inhibitor (BAI1)-binding protein. This adaptor protein links membrane bound G-proteins to cytoplasmic effector proteins. This protein functions as an Insulin Receptor tyrosine kinase substrate and suggests a role for Insulin in the central nervous system. It also associates with a downstream effector of Rho small G proteins, which is associated with the formation of stress fibers and cytokinesis. This protein is involved in lamellipodia and filopodia formation in motile cells and may affect neuronal growth-cone guidance. This protein has also been identified as interacting with the dentatorubral-pallidoluysian atrophy gene, which is associated with an autosomal dominant neurodegenerative disease. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Jan 2009]

BAIAP2 基因产物(35)

mRNA	Protein	Name
NM_001144888.2	NP_001138360.1	brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 4
NM_001385127.1	NP_001372056.1	brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 2
NM_001385128.1	NP_001372057.1	brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 3
NM_001385129.1	NP_001372058.1	brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 5
NM_001385130.1	NP_001372059.1	brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 6
NM_001385131.1	NP_001372060.1	brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 7
NM_001385132.1	NP_001372061.1	brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 8
NM_001385133.1	NP_001372062.1	brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 9
NM_001385134.1	NP_001372063.1	brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 10
NM_001385135.1	NP_001372064.1	brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 11
NM_001385136.1	NP_001372065.1	brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 12
NM_001385137.1	NP_001372066.1	brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 13
NM_001385138.1	NP_001372067.1	brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 14
NM_001385139.1	NP_001372068.1	brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 15
NM_001385140.1	NP_001372069.1	brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 16
NM_001385141.1	NP_001372070.1	brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 17
NM_001385144.1	NP_001372073.1	brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 18
NM_001385145.1	NP_001372074.1	brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 19
NM_001385146.1	NP_001372075.1	brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 19
NM_001385147.1	NP_001372076.1	brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 20
NM_001385148.1	NP_001372077.1	brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 21
NM_001385149.1	NP_001372078.1	brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 21
NM_001385150.1	NP_001372079.1	brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 22
NM_001385151.1	NP_001372080.1	brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 23
NM_001385152.1	NP_001372081.1	brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 24
NM_001385153.1	NP_001372082.1	brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 24
NM_001385154.1	NP_001372083.1	brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 25
NM_001385155.1	NP_001372084.1	brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 25
NM_001385156.1	NP_001372085.1	brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 25
NM_001385157.1	NP_001372086.1	brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 26
NM_001385158.1	NP_001372087.1	brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 27
NM_001385159.1	NP_001372088.1	brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 27
NM_006340.3	NP_006331.1	brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 3
NM_017450.3	NP_059344.1	brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 1
NM_017451.3	NP_059345.1	brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 2

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables identical protein binding	IPI IPI: 通过物理相互作用推断	11696321	GOA
enables proline-rich region binding	IDA IDA: 通过直接分析推断	19366662	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	11130076	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in regulation of actin cytoskeleton organization	IMP IMP: 通过突变表型推断	19366662	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
colocalizes with actin cytoskeleton	IDA IDA: 通过直接分析推断	19366662	GOA
located in cytosol	IDA IDA: 通过直接分析推断	19366662	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

BAIAP2 蛋白结构

IMD

SH3_9

0
100
200
300
400
500
552 a.a.

蛋白主名

其他名称

brain-specific angiogenesis inhibitor 1-associated protein 2

BAI1 associated protein 2

BAIAP2 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	BAIAP2	Q9UQB8	WASF1	Homo sapiens	Q92558	Anti Tag CoIP	33961781
种属内	BAIAP2	Q9UQB8	WASF1	Homo sapiens	Q92558	Anti Tag CoIP	35271311
种属内	BAIAP2	Q9UQB8	BAIAP2L1	Homo sapiens	Q9UHR4	Anti Tag CoIP	26496610
种属内	BAIAP2	Q9UQB8	BAIAP2L1	Homo sapiens	Q9UHR4	Anti Tag CoIP	35271311
种属内	BAIAP2	Q9UQB8	BAIAP2L1	Homo sapiens	Q9UHR4	Anti Tag CoIP	33961781
种属内	BAIAP2	Q9UQB8	KANK1	Homo sapiens	Q14678	Anti Bait CoIP	19171758
种属内	BAIAP2	Q9UQB8	KANK1	Homo sapiens	Q14678	Y2H	19171758
种属内	BAIAP2	Q9UQB8	KANK1	Homo sapiens	Q14678	Confocal	19171758
种属内	BAIAP2	Q9UQB8	CDC42	Homo sapiens	P60953-2	Far-WB	11157984
种属内	BAIAP2	Q9UQB8	CDC42	Homo sapiens	P60953-2	Y2H	11157984
种属内	BAIAP2	Q9UQB8	YWHAZ	Homo sapiens	P63104	Anti Tag CoIP	35271311
种属内	BAIAP2	Q9UQB8	YWHAZ	Homo sapiens	P63104	Anti Tag CoIP	33961781
种属内	BAIAP2	Q9UQB8	ACTB	Homo sapiens	P60709	Anti Bait CoIP	19171758
种属内	BAIAP2	Q9UQB8	YWHAE	Homo sapiens	P62258	Crosslink	36931259
种属内	BAIAP2	Q9UQB8	YWHAE	Homo sapiens	P62258	Anti Tag CoIP	35271311
种属内	BAIAP2	Q9UQB8	ABI1	Homo sapiens	Q8IZP0	Anti Bait CoIP	15289329
种属内	BAIAP2	Q9UQB8	ABI1	Homo sapiens	Q8IZP0	Anti Tag CoIP	35271311
种属内	BAIAP2	Q9UQB8	ABI1	Homo sapiens	Q8IZP0	Anti Tag CoIP	33961781
种属内	BAIAP2	Q9UQB8	EPS8	Homo sapiens	Q12929	Pull Down	15289329
种属内	BAIAP2	Q9UQB8	EPS8	Homo sapiens	Q12929	Anti Tag CoIP	33961781
种属内	BAIAP2	Q9UQB8	EPS8	Homo sapiens	Q12929	Y2H Array	25814554
种属间	BAIAP2	Q9UQB8	Eps8	Mus musculus	Q08509	FRET	15289329
种属间	BAIAP2	Q9UQB8	Eps8	Mus musculus	Q08509	Pull Down	15289329
种属内	BAIAP2	Q9UQB8	RAC1	Homo sapiens	P63000	Y2H	11696321
种属内	BAIAP2	Q9UQB8	RAC1	Homo sapiens	P63000	Anti Bait CoIP	19171758
种属内	BAIAP2	Q9UQB8	YWHAG	Homo sapiens	P61981	Anti Tag CoIP	35271311
种属内	BAIAP2	Q9UQB8	YWHAH	Homo sapiens	Q04917	Anti Tag CoIP	35271311
种属内	BAIAP2	Q9UQB8	YWHAG	Homo sapiens	P61981	CoIP	15324660
种属内	BAIAP2	Q9UQB8	YWHAH	Homo sapiens	Q04917	Anti Tag CoIP	33961781
种属间	BAIAP2	Q9UQB8	Enah	Mus musculus	Q03173	Far-WB	11696321
种属间	BAIAP2	Q9UQB8	Enah	Mus musculus	Q03173	Pull Down	11696321
种属间	BAIAP2	Q9UQB8	Enah	Mus musculus	Q03173	Anti Tag CoIP	11696321
种属间	BAIAP2	Q9UQB8	tir	Escherichia coli O157:H7	Q7DB77	Y2H	25519916
种属内	BAIAP2	Q9UQB8	PRR13	Homo sapiens	Q9NZ81	Y2H Prey Pooling	25416956
种属内	BAIAP2	Q9UQB8	C19orf25	Homo sapiens	Q9UFG5	Y2H Prey Pooling	25416956
种属内	BAIAP2	Q9UQB8	C19orf25	Homo sapiens	Q9UFG5	Y2H Array	25416956
种属内	BAIAP2	Q9UQB8	NCKIPSD	Homo sapiens	Q9NZQ3	Y2H Pooling	16189514
种属内	BAIAP2	Q9UQB8	CDC42	Homo sapiens	P60953	Y2H Pooling	20936779
种属间	BAIAP2	Q9UQB8	Cdc42	Rattus norvegicus	Q8CFN2	Pull Down	18448434

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Dentatorubral-Pallidoluysian Atrophy

DRPLA	Naito-Oyanagi Disease
Haw River Syndrome	Myoclonic Epilepsy With Choreoathetosis
Nod	Ataxia, Chorea, Seizures, And Dementia
Dentatorubropallidoluysian Atrophy	Hrs
Naito Oyanagi Disease	Dentatorubral Pallidoluysian Atrophy
Dentatorubro-Pallidoluysian Atrophy	Myoclonic Epilepsies, Progressive
Atrophy, Pallidoluysian, Dentatorubral

Wiskott-Aldrich Syndrome

WAS	Eczema-Thrombocytopenia-Immunodeficiency Syndrome
Immunodeficiency 2	Aldrich Syndrome
Imd2	Wiskott-Aldrich Syndrome 1
Was1	Wiskott Syndrome
Wiskott Aldrich Syndrome	Eczema Thrombocytopenia Immunodeficiency Syndrome
Imd 2

Noonan Syndrome 1

Noonan Syndrome	NS1
Male Turner Syndrome	Female Pseudo-Turner Syndrome
Turner Phenotype With Normal Karyotype	Noonan Syndrome With Pigmented Villonodular Synovitis
Turner'S Phenotype, Karyotype Normal	Familial Turner Syndrome
Noonan'S Syndrome	Noonan-Ehmke Syndrome
Ns	Pseudo-Ullrich-Turner Syndrome
Turner Syndrome In Female With X Chromosome	Turner-Like Syndrome
Ullrich-Noonan Syndrome	Noonan-Like/Multiple Giant Cell Lesion Syndrome
Noonan Syndrome-Like Disorder With Multiple Giant Cell Lesions	Pterygium Colli Syndrome
Noonan Syndrome, Type 1	Turner Syndrome, Male

Attention Deficit-Hyperactivity Disorder

Attention Deficit Hyperactivity Disorder	ADHD
Attention Deficit Disorder	Attention Deficit-Hyperactivity Disorder, Susceptibility To
Attention Deficit Disorder With Hyperactivity	Hyperkinetic Disorder
Hyperactivity Of Childhood	Attention-Deficit/Hyperactivity Disorder
Add	Addh
Attention Deficit	Attention Deficit Disorder Of Childhood With Hyperactivity
Attention Deficit Disorder With Hyperactivity Syndrome	Hyperkinetic Syndrome
Attention-Deficit Hyperactivity Disorder	Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type
Disturbance Of Activity And Attention	Disorder Of Activity And Attention
Adhd - [Attention Deficit Hyperactivity Disorder]	Hyperkinetic Disorders
Disorder Of Activity And Attention With Hyperkinesia	Attention Deficit Syndrome With Hyperactivity

Non-Syndromic X-Linked Intellectual Disability

X-Linked Non-Syndromic Intellectual Disability	Non-Specific X-Linked Mental Retardation
X-Linked Non-Specific Intellectual Disability

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS01353	BAIAP2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS01354	BAIAP2L1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS01355	BAIAP2L2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	BAIAP2	MGD	MGI:2137336
Macaca mulatta	BAIAP2	VGNC	VGNC:70222
Canis familiaris	BAIAP2	VGNC	VGNC:38371
Felis catus	BAIAP2	VGNC	VGNC:69085
Rattus norvegicus	BAIAP2	RGD	RGD:619814
Bos taurus	BAIAP2	VGNC	VGNC:26412

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