Cdc42 - cell division cycle 42 Gene

种属: Rattus norvegicus

基因 ID: 64465 | 基因类型: protein coding

关于 Cdc42

功能概要

Enables GTP binding activity and mitogen-activated protein kinase kinase kinase binding activity. Involved in several processes, including Cdc42 protein signal transduction; actin filament branching; and regulation of synapse organization. Located in Golgi membrane; plasma membrane; and secretory granule. Is active in Schaffer collateral - CA1 synapse. Biomarker of temporal lobe epilepsy. Human ortholog(s) of this gene implicated in fibrosarcoma. Orthologous to human CDC42 (cell division cycle 42). [provided by Alliance of Genome Resources, Apr 2022]

Cdc42 基因产物(1)

mRNA	Protein	Name
NM_171994.5	NP_741991.3	cell division control protein 42 homolog

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables GTP binding	IDA IDA: 通过直接分析推断	17161586	RGD
enables mitogen-activated protein kinase kinase kinase binding	IPI IPI: 通过物理相互作用推断	17161586	RGD
enables protein binding	IPI IPI: 通过物理相互作用推断	15537656	RGD

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in Golgi organization	IMP IMP: 通过突变表型推断	20525016	RGD
involved in actin filament branching	IMP IMP: 通过突变表型推断	17855387	RGD
involved in actin filament organization	IMP IMP: 通过突变表型推断	21763307	RGD
involved in establishment of Golgi localization	IMP IMP: 通过突变表型推断	20525016	RGD
involved in organelle transport along microtubule	IMP IMP: 通过突变表型推断	20525016	RGD
involved in positive regulation of DNA replication	IMP IMP: 通过突变表型推断	9487126	RGD
involved in positive regulation of JNK cascade	IDA IDA: 通过直接分析推断	17161586	RGD
involved in positive regulation of catalytic activity	IMP IMP: 通过突变表型推断	18562481	RGD
involved in positive regulation of intracellular protein transport	IMP IMP: 通过突变表型推断	21844200	RGD
involved in positive regulation of neuron apoptotic process	IMP IMP: 通过突变表型推断	17161586	RGD
involved in positive regulation of synapse structural plasticity	IMP IMP: 通过突变表型推断	21423166	RGD
involved in regulation of modification of postsynaptic structure	IDA IDA: 通过直接分析推断	21423166	RGD
involved in regulation of modification of postsynaptic structure	IMP IMP: 通过突变表型推断	21423166	RGD
involved in sprouting angiogenesis	IMP IMP: 通过突变表型推断	18562481	RGD
involved in submandibular salivary gland formation	IEP IEP: 通过表达模式推断	18784978	RGD

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in Golgi membrane	IDA IDA: 通过直接分析推断	15147909	RGD
is active in Schaffer collateral - CA1 synapse	IDA IDA: 通过直接分析推断	21423166	RGD
is active in Schaffer collateral - CA1 synapse	IMP IMP: 通过突变表型推断	21423166	RGD
located in plasma membrane	IDA IDA: 通过直接分析推断	15537656	RGD
located in secretory granule	IDA IDA: 通过直接分析推断	15537656	RGD

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

cell division control protein 42 homolog

cell division cycle 42 (GTP binding protein)

cell division cycle 42 homolog

Cdc42 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属间	Cdc42	Q8CFN2	BAIAP2	Homo sapiens	Q9UQB8	Y2H	18448434

种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Clinical Phase

生物活性分子 (1)

目录号	产品名	作用方式	纯度	Phase
HY-I0400	N-Acetylneuraminic acid		99.90%	Phase 1

Pre-clinical Phase

生物活性分子 (31)

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-12646	Rhosin hydrochloride		99.93%	否
HY-12755	ML141		99.87%	否
HY-112842	MBQ-167	Inhibitor	99.86%	否
HY-12874	CASIN		99.89%	否
HY-12810	EHop-016	Inhibitor	99.85%	否
HY-111424	BDP9066	Inhibitor	98.36%	否
HY-13963	ZCL278	Inhibitor	98.46%	否
HY-N0710	alpha-Cyperone		99.80%	否
HY-136379	CID44216842	Inhibitor	99.84%	否
HY-136383	AZA1		98.07%	否
HY-10943	GNF-7	Inhibitor	99.70%	否
HY-113849	MLS-573151	Inhibitor	99.74%	否
HY-115376	Z62954982	Inhibitor	≥99.0%	否
HY-149464	ARN22089	Inhibitor	98.73%	否
HY-111424A	(R)-BDP9066		98.49%	否
HY-15031	l-Naproxen	Inhibitor	99.63%	否
HY-116269	AZA197		98.28%	否
HY-152095	PPI-GIT1/β-Pix interaction-IN-1	Inhibitor	99.01%	否
HY-111423	BDP8900	Inhibitor	/	否
HY-149921	Antiangiogenic agent 3		/	否
HY-161736	ARN25499	Inhibitor	/	否
HY-170327	ZCL279	Inhibitor	/	否
HY-RS02300	CDC42 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS02301	CDC42BPA Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS02302	CDC42BPB Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS02303	CDC42EP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS02304	CDC42EP3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS02305	CDC42EP4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-12646A	Rhosin		/	否
HY-167828	ARN25062	Inhibitor	/	否
HY-D2415	BODIPY-FL staurosporine		/	否

直系同源

种属	基因名	来源	基因 ID
Homo sapiens	Cdc42	NCBI	NCBI:998

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