2. GPCR/G Protein MAPK/ERK Pathway Anti-infection Metabolic Enzyme/Protease
  3. Tyrosinase Ras Influenza Virus Endogenous Metabolite
  4. N-Acetylneuraminic acid

N-Acetylneuraminic acid  (Synonyms: 唾液酸; NANA; Lactaminic acid)

目录号: HY-I0400 纯度: 99.90%
COA 产品使用指南

摩尔计算器

N-Acetylneuraminic acid (NANA; Lactaminic acid) 是一种非酚类结构，是结肠中唾液酸的主要形式。N-Acetylneuraminic acid 在心肌损伤、黑色素瘤和病毒或细菌感染中起生物学作用。N-Acetylneuraminic acid 通过降低酪氨酸酶活性抑制黑色素生成，并通过与 RhoA 和 Cdc42 结合激活 Rho/Rho 相关信号通路，引发体外和体内心肌损伤。N-Acetylneuraminic acid 可能预防高脂肪饮食 (HFD) 引起的炎症和氧化应激，从而预防高脂血症相关的炎症和氧化应激。N-Acetylneuraminic acid 有望用于黑色素瘤，冠状动脉,肥胖相关的疾病和高脂血症领域的研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

N-Acetylneuraminic acid Chemical Structure

N-Acetylneuraminic acid Chemical Structure

CAS No. : 131-48-6

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 价格 是否有货 数量
10 mM * 1 mL in Water ￥550
In-stock
100 mg ￥500
In-stock
1 g ￥700
In-stock
5 g   询价  
10 g   询价  

* Please select Quantity before adding items.

N-Acetylneuraminic acid 相关抗体

Top Publications Citing Use of Products

查看 Ras 亚型特异性产品:

查看所有亚型
K-Ras H-Ras N-Ras Ras

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

N-Acetylneuraminic acid (NANA; Lactaminic acid), a nonphenolic structure, is the predominant form of sialic from Collocalia esculenta. N-Acetylneuraminic acid plays a biological role in myocardial injury, melanoma and viral or bacterial infection. N-Acetylneuraminic acid inhibits melanogenesis by reducing tyrosinase activity and triggers myocardial injury in vitro and in vivo by activation of the Rho/Rho-associated signaling pathway through binding to RhoA and Cdc42. N-Acetylneuraminic acid may prevent high fat diet (HFD)-induced inflammation and oxidative stress, thereby prevents hyperlipidemia-associated inflammation and oxidative stress. N-Acetylneuraminic acid is promising for research in the field of melanoma, coronary artery, obesity-related diseases and hyperlipidemia[1][2][3][4][5].

IC50 & Target

Microbial Metabolite

 

Human Endogenous Metabolite

 

体外研究
(In Vitro)

N-Acetylneuraminic acid (0 - 2 mg/mL, 2 days) 对 B16 黑色素瘤细胞增殖无影响，但显著降低酪氨酸酶蛋白水平，黑素体数量，p62蛋白水平和增加 CCT3，CCT5 mRNA，LC3-II 蛋白水平[1]。
N-Acetylneuraminic acid (0 - 500 μM, 12 h) 特异性结合 RhoA 和 Cdc42，激活心肌细胞中的 Rho/ROCK-JNK/ERK 信号[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

N-Acetylneuraminic acid 相关抗体:

Immunofluorescence[1]

Cell Line: B16 melanoma cells
Concentration: 0 - 2 mg/mL
Incubation Time: 2 days
Result: Was colocalized in the presence of tyrosinase, LAMP-1 and cathepsin L2 at 1 and 2 mg/mL concentrations and reduced p62 levels in B16 melanoma cells.

Real Time qPCR[1]

Cell Line: B16 melanoma cells
Concentration: 0 - 2 mg/mL
Incubation Time: 2 days
Result: Significantly decreased tyrosinase protein level in a concentration-dependent manner and increased CCT3 and CCT5 mRNA levels in B16 melanoma cells.

Western Blot Analysis[1]

Cell Line: B16 melanoma cells
Concentration: 0 - 2 mg/mL
Incubation Time: 2 days
Result: Significantly increased the LC3-II protein level and decreased the p62 protein level at 1 and 2 mg/mL in B16 melanoma cells.

Cell Viability Assay[2]

Cell Line: Neonatal rat ventricular myocytes (NRVMs)
Concentration: 0.05 - 5 mM
Incubation Time: 12 h
Result: Decreased the NRVMs cells viability and increased the release of lactate dehydrogenase and creatine kinase-MB.

Western Blot Analysis[2]

Cell Line: NRVMs cells
Concentration: 0 - 500 μM
Incubation Time: 12 h
Result: Induced significant increase and activation in RhoA and Cdc42, also enhanced the phosphorylation of JNK and ERK in NRVMs cells.
体内研究
(In Vivo)

N-Acetylneuraminic acid (0 - 20 mg/kg, 腹腔注射, 一天 2 次，持续 6 周) 在健康大鼠体内引发心肌损伤[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Healthy rats[2]
Dosage: 0 - 20 mg/kg
Administration: i.p., twice a day for 6 weeks
Result: Increased left ventricular end-diastolic pressure, -dP/dtmax and dp/dtmax, but showed no significant effects on left ventricular systolic pressure in rats.
分子量

309.27

Formula

C11H19NO9
CAS 号
性状

固体

颜色

White to off-white

中文名称

唾液酸；N-乙酰神经氨酸；醋纽拉酸；N-乙酰涎酸；氧-唾液酸；N-乙酰-神经氨 (糖) 酸
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

溶解性数据
细胞实验： 

H2O 中的溶解度 : 125 mg/mL (404.18 mM; 超声助溶)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.2334 mL 16.1671 mL 32.3342 mL
5 mM 0.6467 mL 3.2334 mL 6.4668 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (stored under nitrogen)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物实验：

以下溶解方案，请直接配制工作液。建议现用现配，在短期内尽快用完。 以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比； 如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶。

  • 方案 一

    请依序添加每种溶剂： PBS

    Solubility: 100 mg/mL (323.34 mM); 澄清溶液; 超声助溶 (<60°C)

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
该产品水溶性佳，请具体参考实测 水 / PBS / Saline 中的溶解度数据。
您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
纯度 & 产品资料

纯度: 99.90%

COA (286 KB) HNMR (260 KB) RP-HPLC (215 KB) LCMS (89 KB)

产品使用指南 (1538 KB)
参考文献

N-Acetylneuraminic acid 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (stored under nitrogen)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 3.2334 mL 16.1671 mL 32.3342 mL 80.8355 mL
5 mM 0.6467 mL 3.2334 mL 6.4668 mL 16.1671 mL
10 mM 0.3233 mL 1.6167 mL 3.2334 mL 8.0836 mL
15 mM 0.2156 mL 1.0778 mL 2.1556 mL 5.3890 mL
20 mM 0.1617 mL 0.8084 mL 1.6167 mL 4.0418 mL
25 mM 0.1293 mL 0.6467 mL 1.2934 mL 3.2334 mL
30 mM 0.1078 mL 0.5389 mL 1.0778 mL 2.6945 mL
40 mM 0.0808 mL 0.4042 mL 0.8084 mL 2.0209 mL
50 mM 0.0647 mL 0.3233 mL 0.6467 mL 1.6167 mL
60 mM 0.0539 mL 0.2695 mL 0.5389 mL 1.3473 mL
80 mM 0.0404 mL 0.2021 mL 0.4042 mL 1.0104 mL
100 mM 0.0323 mL 0.1617 mL 0.3233 mL 0.8084 mL

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

N-Acetylneuraminic acid131-48-6NANA Lactaminic acid唾液酸N-乙酰神经氨酸醋纽拉酸N-乙酰涎酸氧-唾液酸N-乙酰-神经氨 (糖) 酸TyrosinaseRasInfluenza VirusEndogenous Metabolitesialicmelanogenesismyocardial injuryviral or bacterial infectionRhoACdc42melanomacoronary artery diseasesobesity-related diseasesinflammationoxidative stressInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
N-Acetylneuraminic acid
目录号：
HY-I0400
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z