2. Gene
  3. BAIAP2L1 - BAR/IMD domain containing adaptor protein 2 like 1 Gene

BAIAP2L1 - BAR/IMD domain containing adaptor protein 2 like 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：含 BAR/IMD 域适配因子蛋白 2 样 1

种属: Homo sapiens

同用名: IRTKS

基因 ID: 55971 | 基因类型: protein coding

关于 BAIAP2L1

Cytogenetic location: 7q21.3-q22.1 Genomic coordinates (GRCh38): 7:98,291,650-98,401,090 (from NCBI)

This gene has 5 transcripts (splice variants), 277 orthologues and 2 paralogues. Broad expression in stomach (RPKM 26.9), colon (RPKM 14.1) and 19 other tissues.

功能概要

该基因编码 IMD (IRSp53/MIM 同源域) 家族的成员。根据是否存在 SH3 (Src 同源 3) 结构域，该家族的成员可分为两组，类 IRSp53 和类 MIM。该基因编码的蛋白质在 N 端含有一个保守的 IMD，也称为 F-肌动蛋白捆绑结构域，在 C 端附近含有一个典型的 SH3 结构域，因此属于 IRSp53-like 组。这种蛋白质是胰岛素受体酪氨酸激酶的底物，并与小 GTPase Rac 结合。它参与连接质膜变形和肌动蛋白细胞骨架重塑的信号转导通路。当在哺乳动物细胞中过度表达时，它还会促进肌动蛋白组装和膜突起，并且对于在 EHEC (肠出血性大肠杆菌) 基座形成过程中形成有效的肌动蛋白组装复合物至关重要。[RefSeq 提供，2009 年 10 月]

This gene encodes a member of the IMD (IRSp53/MIM homology domain) family. Members of this family can be subdivided in two groups, the IRSp53-like and MIM-like, based on the presence or absence of the SH3 (Src homology 3) domain. The protein encoded by this gene contains a conserved IMD, also known as F-actin bundling domain, at the N-terminus, and a canonical SH3 domain near the C-terminus, so it belongs to the IRSp53-like group. This protein is the substrate for Insulin Receptor tyrosine kinase and binds to the small GTPase Rac. It is involved in signal transduction pathways that link deformation of the plasma membrane and remodeling of the actin Cytoskeleton. It also promotes actin assembly and membrane protrusions when overexpressed in mammalian cells, and is essential to the formation of a potent actin assembly complex during EHEC (Enterohemorrhagic Escherichia coli) pedestal formation. [provided by RefSeq, Oct 2009]

BAIAP2L1 基因产物(1)

mRNA Protein Name
NM_018842.5 NP_061330.2 brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables proline-rich region binding IDA
IDA: 通过直接分析推断
21098279 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
21098279 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of actin filament polymerization IDA
IDA: 通过直接分析推断
21098279 GOA
involved in regulation of actin cytoskeleton organization IMP
IMP: 通过突变表型推断
19366662 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
colocalizes with actin cytoskeleton IDA
IDA: 通过直接分析推断
19366662 GOA
located in cytosol IDA
IDA: 通过直接分析推断
19366662 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

BAIAP2L1 蛋白结构

IMD

IMD: IRSp53/MIM homology domain (16 - 236)

SH3_9

SH3_9: Variant SH3 domain (347 - 398)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 511 a.a.
蛋白主名 其他名称

brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1

BAI1 associated protein 2 like 1

BAIAP2L1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Cross BAIAP2L1 Q9UHR4 espF(U) Escherichia coli O157:H7 P0DJ89
ITC
21098279
Cross BAIAP2L1 Q9UHR4 espF(U) Escherichia coli O157:H7 P0DJ89
Peptide Array
21098279
Cross BAIAP2L1 Q9UHR4 espF(U) Escherichia coli O157:H7 P0DJ89
ITC
22921828
Cross BAIAP2L1 Q9UHR4 espF(U) Escherichia coli O157:H7 P0DJ89
Y2H
22921828
Cross BAIAP2L1 Q9UHR4 espF(U) Escherichia coli O157:H7 P0DJ89
NMR
21098279
Cross BAIAP2L1 Q9UHR4 espF(U) Escherichia coli O157:H7 P0DJ89
NMR
22921828
Intra BAIAP2L1 Q9UHR4 EPS8 Homo sapiens Q12929
NMR
22921828
Intra BAIAP2L1 Q9UHR4 EPS8 Homo sapiens Q12929
Pull Down
22921828
Intra BAIAP2L1 Q9UHR4 EPS8 Homo sapiens Q12929
ITC
22921828
Intra BAIAP2L1 Q9UHR4 EPS8 Homo sapiens Q12929
Peptide Array
21098279
Intra BAIAP2L1 Q9UHR4 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
Intra BAIAP2L1 Q9UHR4 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
Intra BAIAP2L1 Q9UHR4 BAIAP2 Homo sapiens Q9UQB8
Anti Tag CoIP
35271311
Intra BAIAP2L1 Q9UHR4 BAIAP2 Homo sapiens Q9UQB8-6
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Dentatorubral-Pallidoluysian Atrophy

DRPLA

Naito-Oyanagi Disease

Haw River Syndrome

Myoclonic Epilepsy With Choreoathetosis

Nod

Ataxia, Chorea, Seizures, And Dementia

Dentatorubropallidoluysian Atrophy

Hrs

Naito Oyanagi Disease

Dentatorubral Pallidoluysian Atrophy

Dentatorubro-Pallidoluysian Atrophy

Myoclonic Epilepsies, Progressive

Atrophy, Pallidoluysian, Dentatorubral
Donohue Syndrome

Leprechaunism

Leprechaunism Syndrome

Donohue'S Syndrome

LEPRCH
Acanthosis Nigricans

Keratosis Nigricans

An
Type 2 Diabetes Mellitus

Insulin Resistance

NIDDM

Type 2 Diabetes

Diabetes Mellitus, Non-Insulin-Dependent

T2D

Noninsulin-Dependent Diabetes Mellitus

Diabetes Mellitus, Type Ii

Maturity-Onset Diabetes

Insulin Resistance, Severe, Digenic

Diabetes Mellitus, Type 2

Diabetes Mellitus, Noninsulin-Dependent

Diabetes Mellitus, Noninsulin-Dependent, Association With

Diabetes Mellitus, Noninsulin-Dependent, Late Onset

Hypertension, Insulin Resistance-Related, Susceptibility To

Insulin Resistance, Susceptibility To

Non-Insulin-Dependent Diabetes Mellitus

Type Ii Diabetes Mellitus

Adult-Onset Diabetes Mellitus

Maturity-Onset Diabetes Mellitus

Diabetes Mellitus Type 2

Type Ii Diabetes

Type 2 Diabetes Mellitus, Susceptibility To

Diabetes, Type 2

Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

Diabetes Mellitus, Type 2, Susceptibility To

Diabetes Mellitus, Noninsulin-Dependent, 2

Diabetes Mellitus, Type Ii, Susceptibility To

Hypertension, Insulin Resistance-Related

Adult-Onset Diabetes

Aodm

Diabetes Mellitus, Adult-Onset

Diabetes Mellitus Type Ii

Diabetes Mellitus Type 2, Susceptibility To

Diabetes, Type Ii, Susceptibility To

Diabetes Type 2

Diabetes Mellitus

Adult Onset Diabetes

Maturity Onset Diabetes

Nonketotic Diabetes

Non-Insulin Dependent Diabetes Mellitus

T2dm - [Type 2 Diabetes Mellitus]

Niddm - [Non Insulin Dependent Diabetes Mellitus]

Dm2

Dm Type Ii

Diabetic Type 2

Insulin Requiring Type 2 Diabetes

Noninsulin Dependent Diabetes

Non-Insulin-Dependent Diabetes Mellitus Without Complications

Diabetes Due To Insulin Secretory Defect

Diabetes Mellitus Due To Insulin Secretory Defect

Non-Insulin-Dependent Diabetes Of The Young

Senile Diabetes

Nonketotic Hyperglycaemia

Stable Diabetes
Hypogonadotropic Hypogonadism 6 With Or Without Anosmia

HH6

Kallmann Syndrome 6

Kal6

Hypogonadotropic Hypogonadism, Type 6 With/Without Anosmia
Gestational Diabetes

Gestational Diabetes Mellitus

GDM

Diabetes Mellitus Arising In Pregnancy

Maternal Gestational Diabetes Mellitus

Diabetes Mellitus, Gestational

Diabetes Mellitus, Pregnancy Related

Diabetes, Pregnancy-Induced

Diabetes Gestational

Diabetes, Gestational

Diabetes Of Pregnancy

Gdm - [Gestational Diabetes Mellitus]

Gestational Diabetes Mellitus Nos

Gestational Diabetes Complicating Pregnancy, Childbirth, Or The Puerperium
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS01354 BAIAP2L1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta BAIAP2L1 VGNC VGNC:70109
Felis catus BAIAP2L1 VGNC VGNC:60071
Rattus norvegicus BAIAP2L1 RGD RGD:1308452
Mus musculus BAIAP2L1 MGD MGI:1914148
Bos taurus BAIAP2L1 VGNC VGNC:26413
Canis familiaris BAIAP2L1 VGNC VGNC:38372
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