YWHAG - tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma Gene

中文名称：酪氨酸 3-单加氧酶/色氨酸 5-单加氧酶激活蛋白 γ

种属: Homo sapiens

同用名: DEE56; EIEE56; PPP1R170; 14-3-3GAMMA

关于 YWHAG

功能概要

该基因产物属于 14-3-3 蛋白家族，通过与含磷酸丝氨酸的蛋白结合来介导信号转导。这种高度保守的蛋白质家族存在于植物和哺乳动物中，并且这种蛋白质与大鼠直系同源物 100% 相同。它由人血管平滑肌细胞中的生长因子诱导，在骨骼肌和心肌中也高度表达，表明这种蛋白质在肌肉组织中具有重要作用。它已被证明与 RAF1 和蛋白激酶 C 相互作用，这些蛋白质参与各种信号转导途径。[RefSeq 提供，2008 年 7 月]

This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both Plants and mammals, and this protein is 100% identical to the rat ortholog. It is induced by growth factors in human vascular smooth muscle cells, and is also highly expressed in skeletal and heart muscles, suggesting an important role for this protein in muscle tissue. It has been shown to interact with RAF1 and protein kinase C, proteins involved in various signal transduction pathways. [provided by RefSeq, Jul 2008]