2. Gene
  3. CRTC3 - CREB regulated transcription coactivator 3 Gene

CRTC3 - CREB regulated transcription coactivator 3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：CREB 调节转录辅激活因子 3

种属: Homo sapiens

同用名: TORC3; TORC-3

基因 ID: 64784 | 基因类型: protein coding

关于 CRTC3

Cytogenetic location: 15q26.1 Genomic coordinates (GRCh38): 15:90,529,923-90,645,345 (from NCBI)

This gene has 18 transcripts (splice variants), 200 orthologues, 2 paralogues and is associated with 66 phenotypes. Ubiquitous expression in ovary (RPKM 20.6), fat (RPKM 11.8) and 25 other tissues.

功能概要

该基因是 CREB 调节转录共激活因子基因家族的成员。该家族以不依赖磷酸化的方式调节 CREB 依赖性基因转录，并且可能对 cAMP 反应基因具有选择性。由该基因编码的蛋白质可能会诱导线粒体生物发生并减弱脂肪组织中的儿茶酚胺信号。该基因与 Notch 辅激活因子 mastermind-like 基因 2 之间的易位事件导致融合蛋白，已在粘液表皮样癌中报道。可变剪接导致编码不同蛋白质亚型的多个转录变体。[RefSeq 提供，2012 年 7 月]

This gene is a member of the CREB regulated transcription coactivator gene family. This family regulates CREB-dependent gene transcription in a phosphorylation-independent manner and may be selective for cAMP-responsive genes. The protein encoded by this gene may induce mitochondrial biogenesis and attenuate Catecholamine signaling in adipose tissue. A translocation event between this gene and Notch coactivator mastermind-like gene 2, which results in a fusion protein, has been reported in mucoepidermoid carcinomas. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]

CRTC3 基因产物(2)

mRNA Protein Name
NM_001042574.3 NP_001036039.1 CREB-regulated transcription coactivator 3 isoform b
NM_022769.5 NP_073606.3 CREB-regulated transcription coactivator 3 isoform a
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
20936779 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in macrophage activation IMP
IMP: 通过突变表型推断
23033494 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CRTC3 蛋白结构

TORC_N

TORC_N: Transducer of regulated CREB activity, N terminus (11 - 64)

TORC_M

TORC_M: Transducer of regulated CREB activity middle domain (159 - 322)

TORC_C

TORC_C: Transducer of regulated CREB activity, C terminus (545 - 619)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 619 a.a.
蛋白主名 其他名称

CREB-regulated transcription coactivator 3

transducer of regulated CREB protein 3

CRTC3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
CRTC3 Q6UUV7 CA13 Homo sapiens Q8N1Q1
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

CRTC3 抗体

目录号 产品名 应用 反应物种
HY-P82003 CRTC3 Antibody (YA1748) WB, ICC/IF Human, Mouse, Rat

关联疾病

疾病名称 别名
Human T-Cell Leukemia Virus Type 1

Htlv-1

Human T Lymphotropic Virus Type 1
Esophageal Adenoid Cystic Carcinoma

Adenoid Cystic Carcinoma, Esophagus
Salivary Gland Carcinoma

Salivary Gland Cancer

Malignant Neoplasm Of Salivary Gland

Salivary Gland Neoplasms
Lacrimal Gland Mucoepidermoid Carcinoma

Mucoepidermoid Carcinoma Of The Lacrimal Gland
Hidradenoma

Adenoma, Sweat Gland

Hidradenoma Of Skin

Sweat Gland Adenoma

Syringoadenoma

Eccrine Acrospiroma

Benign Neoplasm Of Sweat Gland
Pleomorphic Adenoma Carcinoma

Carcinoma Ex Pleomorphic Adenoma

Carcinoma In Pleomorphic Adenoma
Salivary Gland Disease

Salivary Gland Disorders

Salivary Gland Diseases

Non-Neoplastic Salivary Gland Disease

Non-Neoplastic Salivary Gland Disorder

Disorder Of Salivary Gland

Lesion Of Salivary Gland Nos
Epithelial-Myoepithelial Carcinoma

Clear Cell Adenoma

Adenomyo-Epithelioma

Clear Cell Carcinoma

Emc

Epithelial Myoepithelial Carcinoma

Glycogen-Rich Adenocarcinoma

Glycogen-Rich Adenoma

Monomorphic Clear Cell Tumor

Tubular Solid Adenoma

Adenocarcinoma, Clear Cell
Clear Cell Hidradenoma

Clear Cell Myoepithelioma

Eccrine Acrospiroma
Tonsil Cancer

Tonsillar Neoplasms

Malignant Neoplasm Of Faucial Tonsil

Malignant Neoplasm Of Palatine Tonsil

Malignant Neoplasm Of Tonsil, Faucial

Malignant Tonsillar Tumor

Malignant Tumor Of Tonsil

Tonsillar Carcinoma

Malignant Neoplasm Tonsil
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-120877 MRT199665 99.74% 否
HY-120877A (R)-MRT199665 98.70% 否
HY-RS03202 CRTC3 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus CRTC3 VGNC VGNC:61194
Bos taurus CRTC3 VGNC VGNC:27729
Rattus norvegicus CRTC3 RGD RGD:1309666
Mus musculus CRTC3 MGD MGI:1917711
Canis familiaris CRTC3 VGNC VGNC:53163
Macaca mulatta CRTC3 VGNC VGNC:71584
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z