2. Gene
  3. SH3BP4 - SH3 domain binding protein 4 Gene

SH3BP4 - SH3 domain binding protein 4 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：SH3 结构域结合蛋白 4

种属: Homo sapiens

同用名: TTP; BOG25

基因 ID: 23677 | 基因类型: protein coding

关于 SH3BP4

Cytogenetic location: 2q37.2 Genomic coordinates (GRCh38): 2:234,952,017-235,055,714 (from NCBI)

This gene has 11 transcripts (splice variants), 277 orthologues and 1 paralogue. Ubiquitous expression in salivary gland (RPKM 12.0), gall bladder (RPKM 8.4) and 24 other tissues.

功能概要

该基因编码的蛋白质具有 3 个 Asn-Pro-Phe (NPF) 基序、一个 SH3 结构域、一个 PXXP 基序、一个二分核靶向信号和一个酪氨酸磷酸化位点。这种蛋白质参与网格蛋白介导的内吞作用的货物特异性控制，特别是控制特定蛋白质受体的内化。[RefSeq 提供，2008 年 7 月]

This gene encodes a protein with 3 Asn-Pro-Phe (NPF) motifs, an SH3 domain, a PXXP motif, a bipartite nuclear targeting signal, and a tyrosine phosphorylation site. This protein is involved in cargo-specific control of clathrin-mediated endocytosis, specifically controlling the internalization of a specific protein receptor. [provided by RefSeq, Jul 2008]

SH3BP4 基因产物(6)

mRNA Protein Name
NM_001371302.1 NP_001358231.1 SH3 domain-binding protein 4
NM_001371303.1 NP_001358232.1 SH3 domain-binding protein 4
NM_001371304.1 NP_001358233.1 SH3 domain-binding protein 4
NM_001371305.1 NP_001358234.1 SH3 domain-binding protein 4
NM_001371306.1 NP_001358235.1 SH3 domain-binding protein 4
NM_014521.3 NP_055336.1 SH3 domain-binding protein 4
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables GDP-dissociation inhibitor activity IMP
IMP: 通过突变表型推断
22575674 GOA
enables identical protein binding IPI
IPI: 通过物理相互作用推断
16325581 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
15161933 GOA
enables small GTPase binding IPI
IPI: 通过物理相互作用推断
22575674 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
NOT involved in amino acid import IMP
IMP: 通过突变表型推断
22575674 GOA
involved in cellular response to amino acid stimulus IMP
IMP: 通过突变表型推断
22575674 GOA
involved in negative regulation of GTPase activity IDA
IDA: 通过直接分析推断
22575674 GOA
involved in negative regulation of TOR signaling IMP
IMP: 通过突变表型推断
22575674 GOA
involved in negative regulation of cell growth IMP
IMP: 通过突变表型推断
22575674 GOA
involved in negative regulation of cell population proliferation IMP
IMP: 通过突变表型推断
22575674 GOA
involved in positive regulation of autophagy IMP
IMP: 通过突变表型推断
22575674 GOA
involved in protein localization to lysosome IMP
IMP: 通过突变表型推断
22575674 GOA
involved in regulation of catalytic activity IMP
IMP: 通过突变表型推断
22575674 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
22575674 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SH3BP4 蛋白结构

SH3_9

SH3_9: Variant SH3 domain (62 - 110)

ZU5

ZU5: ZU5 domain (322 - 403)

SH3_2

SH3_2: Variant SH3 domain (658 - 721)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 963 a.a.
蛋白主名 其他名称

SH3 domain-binding protein 4

EH-binding protein 10

SH3BP4 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
SH3BP4 Q9P0V3 GIPC1 Homo sapiens O14908
Anti Tag CoIP
29467281
种属内
SH3BP4 Q9P0V3 YWHAG Homo sapiens P61981
CoIP
15324660
种属内
SH3BP4 Q9P0V3 YWHAG Homo sapiens P61981
Y2H Pooling
20936779
种属内
SH3BP4 Q9P0V3 CIZ1 Homo sapiens Q9ULV3
Anti Tag CoIP
18654987
种属内
SH3BP4 Q9P0V3 PLEKHA1 Homo sapiens Q9HB21
Y2H
18654987
种属内
SH3BP4 Q9P0V3 DNM2 Homo sapiens P50570
Anti Bait CoIP
16325581
种属内
SH3BP4 Q9P0V3 DNM2 Homo sapiens P50570
Anti Tag CoIP
16325581
种属内
SH3BP4 Q9P0V3 YWHAZ Homo sapiens P63104
Pull Down
15161933
种属内
SH3BP4 Q9P0V3 CFTR Homo sapiens P13569
Ub Reconstruction
35156780
种属内
SH3BP4 Q9P0V3 TFRC Homo sapiens P02786
Anti Bait CoIP
16325581
种属内
SH3BP4 Q9P0V3 TFRC Homo sapiens P02786
SPR
16325581
种属内
SH3BP4 Q9P0V3 TFRC Homo sapiens P02786
Anti Tag CoIP
16325581
种属内
SH3BP4 Q9P0V3 TFRC Homo sapiens P02786
Pull Down
16325581
种属内
SH3BP4 Q9P0V3 TFRC Homo sapiens P02786
Competition Binding
16325581
种属间
SH3BP4 Q9P0V3 Dnm2 Rattus norvegicus P39052
Pull Down
16325581
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Molluscum Contagiosum

Water Warts

Molluscum Verrucosum
Metacarpal 4-5 Fusion

Syndactyly Type 8

MF4

Fusion Of Metacarpals 4 And 5

Metacarpals 4 And 5 Fusion

Metacarpal 4 5 Fusion
Cardiomyopathy, Familial Hypertrophic, 2

Hypertrophic Cardiomyopathy 2

CMH2

Cardiomyopathy, Hypertrophic, 2

Cardiomyopathy Familial Hypertrophic 2

Cardiomyopathy, Familial Hypertrophic 2

Cardiomyopathy, Hypertrophic, Familial, Type 2
Waardenburg Syndrome, Type 4a

Waardenburg-Shah Syndrome

Shah-Waardenburg Syndrome

Waardenburg Syndrome Type 4a

WS4A

Ws4

Waardenburg Syndrome Type 4

Waardenburg Syndrome Type Iva

Waardenburg Syndrome With Hirschsprung Disease Type 4a

Hirschsprung Disease With Pigmentary Anomaly

Waardenburg-Hirschsprung Syndrome

Waardenburg Syndrome, Type Iva

Waardenburg Syndrome With Hirschsprung Disease, Type 4a

Waardenburg-Hirschsprung Disease

Waardenburg Syndrome, Type 4

Waardenburg Syndrome 4a
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12832 SH3BP4 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus SH3BP4 RGD RGD:620219
Canis familiaris SH3BP4 VGNC VGNC:46119
Macaca mulatta SH3BP4 VGNC VGNC:77202
Bos taurus SH3BP4 VGNC VGNC:34567
Felis catus SH3BP4 VGNC VGNC:65102
Mus musculus SH3BP4 MGD MGI:2138297
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