2. Gene
  3. CIZ1 - CDKN1A interacting zinc finger protein 1 Gene

CIZ1 - CDKN1A interacting zinc finger protein 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：CDKN1A 相互作用锌指蛋白 1

种属: Homo sapiens

同用名: NP94; LSFR1; ZNF356

基因 ID: 25792 | 基因类型: protein coding

关于 CIZ1

Cytogenetic location: 9q34.11 Genomic coordinates (GRCh38): 9:128,166,065-128,204,222 (from NCBI)

This gene has 28 transcripts (splice variants), 243 orthologues and is associated with 1 phenotype. Ubiquitous expression in ovary (RPKM 30.0), testis (RPKM 29.2) and 25 other tissues.

功能概要

该基因编码的蛋白质是与 CIP1 相互作用的锌指 DNA 结合蛋白，CIP1 是与细胞周期蛋白 E 形成的复合物的一部分。编码的蛋白质可能调节 CIP1 的细胞定位。已发现该基因编码不同亚型的几种转录变体。[RefSeq 提供，2012 年 4 月]

The protein encoded by this gene is a zinc finger DNA binding protein that interacts with CIP1, part of a complex with cyclin E. The encoded protein may regulate the cellular localization of CIP1. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]

CIZ1 基因产物(7)

mRNA Protein Name
NM_001131015.2 NP_001124487.1 cip1-interacting zinc finger protein isoform 2
NM_001131016.2 NP_001124488.1 cip1-interacting zinc finger protein isoform 1
NM_001131017.2 NP_001124489.1 cip1-interacting zinc finger protein isoform 3
NM_001131018.2 NP_001124490.1 cip1-interacting zinc finger protein isoform 4
NM_001257975.2 NP_001244904.1 cip1-interacting zinc finger protein isoform 5
NM_001257976.2 NP_001244905.1 cip1-interacting zinc finger protein isoform 6
NM_012127.3 NP_036259.2 cip1-interacting zinc finger protein isoform 1
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
18654987 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
23145069 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CIZ1 蛋白结构

zf-C2H2_jaz

zf-C2H2_jaz: Zinc-finger double-stranded RNA-binding (686 - 710)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 898 a.a.
蛋白主名 其他名称

cip1-interacting zinc finger protein

nuclear protein NP94

CIZ1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
CIZ1 Q9ULV3 SH3BP4 Homo sapiens Q9P0V3
Y2H
18654987
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Developmental And Epileptic Encephalopathy 31

DEE31

Epileptic Encephalopathy, Early Infantile, 31

Eiee31

Developmental And Epileptic Encephalopathy, 31

Early Infantile Epileptic Encephalopathy 31

Encephalopathy, Epileptic, Early Infantile, Type 31
Cervical Dystonia

Spasmodic Torticollis
Dystonia 23

DYT23

Adult-Onset Cervical Dystonia, Dyt23 Type

Dystonia, Type 23
Motor Stereotypies

Motor Stereotypy
Stereotypic Movement Disorder

Stereotypy Habit Disorder

Stereotyped Repetitive Movements

Stereotyped Disorder

Stereotypes Nos

Stereotype Habit Disorder
Focal Dystonia

Dystonia, Focal, Task-Specific
Torsion Dystonia 2

Dystonia 2, Torsion, Autosomal Recessive
Aceruloplasminemia

Cerebellar Ataxia

Hypoceruloplasminemia

Hemosiderosis, Systemic, Due To Aceruloplasminemia

Familial Apoceruloplasmin Deficiency

Hereditary Ceruloplasmin Deficiency

Deficiency Of Ferroxidase

Hypoceruloplasminemia, Hereditary

Ceruloplasmin Deficiency

Systemic Hemosiderosis Due To Aceruloplasminemia

ACERULOP
Hypotonia
Dystonia 25

DYT25

Dystonia-25

Dystonia, Type 25
Torsion Dystonia 4
Dystonia 1, Torsion, Autosomal Dominant

Dystonia Musculorum Deformans 1

Dystonia Musculorum Deformans

DYT1

Early-Onset Torsion Dystonia

Eotd

Dystonia-1, Torsion

Torsion Dystonia 1

Autosomal Dominant Torsion Dystonia 1

Dystonia-1

Oppenheim'S Dystonia

Oppenheim-Ziehen Disease

Early Onset Torsion Dystonia

Dystonia 3, Torsion, X-Linked
Torticollis

Contracture Of Neck

Wry Neck

Wry Neck/Torticollis
Dystonia

Dystonic Disease

Dystonic Disorder

Dystonia Disorders

Neuroleptic Dyskinesia
Segmental Dystonia
Dystonia 6, Torsion

DYT6

Torsion Dystonia 6

Dystonia 6

Idiopathic Torsion Dystonia Of Mixed Type

Primary Dystonia, Dyt6 Type

Torsion Dystonia, Adult-Onset, Mixed Type

Dyt-Thap1

Adolescent-Onset Dystonia Of Mixed Type

Torsion Dystonia Adult Onset Mixed Type

Dyt6 Dystonia

Thap1 Dystonia

Generalized Cervical And Upper-Limb-Onset Dystonia

Adult-Onset Torsion Dystonia Mixed Type

Autosomal Dominant Torsion Dystonia 6

Dystonia-6

Torsion Dystonia Type 6

Dystonia, Type 6, Torsion
Dystonia 27

DYT27

Primary Dystonia, Dyt27 Type

Dystonia, Type 27
Multifocal Dystonia
Spasmodic Dystonia

Laryngeal Dystonia
Jaw Cancer

Jaw Neoplasms

Jaw Neoplasm

Neoplasm Of Jaw

Cancer Of Jaw
Leukodystrophy, Hypomyelinating, 6

Habc

Hypomyelinating Leukodystrophy 6

HLD6

H-Abc

Hypomyelination With Atrophy Of Basal Ganglia And Cerebellum

Leukodystrophy, Hypomyelinating, With Atrophy Of The Basal Ganglia And Cerebellum

Hypomyelinating Leukodystrophy With Atrophy Of The Basal Ganglia And Cerebellum

HLD

Leukodystrophy, Hypomyelinating, Type 6
Hereditary Lymphedema Ii

Meige Syndrome

Meige Disease

Meige Lymphedema

Hereditary Lymphedema Type Ii

Lymphedema Hereditary Type 2

Lymphedema Praecox

Lymphedema, Hereditary, Ii

Blepharospasm-Oromandibular Dystonia Syndrome

Meige Dystonia

Meige'S Syndrome

Late-Onset Lymphedema

Lmph2

Lymphedema Preacox

Lymphedema, Late-Onset

Blepharospasm - Oromandibular Dystonia

Blepharospasm-Oromandibular Dystonia

Brueghel Syndrome

Idiopathic Blepharospasm-Oromandibular Dystonia Syndrome

Oral Facial Dystonia

Segmental Cranial Dystonia

Meigs Syndrome
Blepharospasm
Oromandibular Dystonia
Hemidystonia
Lymphatic Malformation 5

Meige Syndrome

Meige Disease

Meige Lymphedema

Lymphedema Praecox

Lymphedema, Late-Onset

Late-Onset Lymphedema

LMPH2

Meigs Syndrome

LMPHM5

Lymphedema, Hereditary, Ii, Formerly

Lmph2, Formerly

Hereditary Lymphedema Ii

Demons-Meigs Syndrome

Hereditary Lymphedema Type Ii

Lymphedema, Hereditary, 2

Lymphedema, Hereditary, Ii

Meige'S Disease
Alternating Hemiplegia Of Childhood

Alternating Hemiplegia

Ahc

Alternating Hemiplegia Syndrome

Hemiplegia, Alternating, Of Childhood

Hemiplegia, Crossed
Focal Hand Dystonia

Organic Writer'S Cramp

Dystonia, Focal, Task-Specific
Dystonia 12

DYT12

Rdp

Generalized Dystonia

Dystonia-12

Rapid-Onset Dystonia-Parkinsonism

Familial Dystonia

Dystonia Musculorum Deformans

Dystonic Disorders

Idiopathic Familial Dystonia

Dystonia-Parkinsonism, Rapid-Onset

Fragments Of Torsion Dystonia

Dyt-Atp1a3

Rapid-Onset Dystonia Parkinsonism

Rodp

Dystonia, Type 12

Dystonia 3, Torsion, X-Linked

Idiopathic Non-Familial Dystonia

Symptomatic Torsion Dystonia

Dystonia Disorders
Dystonia 11, Myoclonic

Myoclonic Dystonia

Myoclonus-Dystonia Syndrome

DYT11

Myoclonic Dystonia 11

Alcohol-Responsive Dystonia

Myoclonus, Hereditary Essential

Dystonia-11, Myoclonic

Myoclonus-Dystonia

Dystonia 11

Hereditary Essential Myoclonus

Dystonia, Alcohol-Responsive

Dyt-Sgce

Dystonia, Alcohol Responsive

Dystonia-11

Dystonia, Myoclonic

Dystonia, Myoclonic, Type 11
Movement Disease

Movement Disorders

Movement Disorder
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS02731 CIZ1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus CIZ1 VGNC VGNC:27379
Macaca mulatta CIZ1 VGNC VGNC:71184
Rattus norvegicus CIZ1 RGD RGD:1305336
Mus musculus CIZ1 MGD MGI:1920234
Felis catus CIZ1 VGNC VGNC:60911
Canis familiaris CIZ1 VGNC VGNC:39285
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