Dnm2 - dynamin 2 Gene

种属: Rattus norvegicus

同用名: DYIIAAB

基因 ID: 25751 | 基因类型: protein coding

关于 Dnm2

功能概要

Enables several functions, including D2 Dopamine Receptor binding activity; Enzyme binding activity; and protein domain specific binding activity. Involved in several processes, including positive regulation of transport; regulation of plasma membrane bounded cell projection assembly; and regulation of signal transduction. Located in several cellular components, including Golgi apparatus; cytoplasmic vesicle; and ruffle membrane. Part of protein-containing complex. Is active in glutamatergic synapse and postsynaptic density, intracellular component. Colocalizes with growth cone. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease dominant intermediate B; centronuclear myopathy 1; and lethal congenital contracture syndrome. Orthologous to human DNM2 (Dynamin 2). [provided by Alliance of Genome Resources, Apr 2022]

Dnm2 基因产物(1)

mRNA	Protein	Name
NM_013199.2	NP_037331.1	dynamin-2

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables D2 dopamine receptor binding	IPI IPI: 通过物理相互作用推断	14709338	RGD
enables GTPase activity	IDA IDA: 通过直接分析推断	16325581	RGD
enables SH3 domain binding	IPI IPI: 通过物理相互作用推断	19122684	RGD
enables WW domain binding	IPI IPI: 通过物理相互作用推断	23994472	RGD
enables nitric-oxide synthase binding	IDA IDA: 通过直接分析推断	21490139	RGD
enables phosphatidylinositol 3-kinase regulatory subunit binding	IDA IDA: 通过直接分析推断	12205083	RGD
enables protein binding	IPI IPI: 通过物理相互作用推断	11583995	RGD
enables protein kinase binding	IPI IPI: 通过物理相互作用推断	15007081	RGD
enables protein serine/threonine kinase binding	IPI IPI: 通过物理相互作用推断	20802490	RGD
enables protein-containing complex binding	IDA IDA: 通过直接分析推断	17257598	RGD

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in G protein-coupled receptor internalization	IMP IMP: 通过突变表型推断	14709338	RGD
involved in Golgi to plasma membrane transport	IMP IMP: 通过突变表型推断	20231454	RGD
involved in actin filament bundle organization	IMP IMP: 通过突变表型推断	19605363	RGD
involved in cellular response to X-ray	IEP IEP: 通过表达模式推断	15994918	RGD
involved in cellular response to carbon monoxide	IEP IEP: 通过表达模式推断	25100282	RGD
involved in cellular response to dopamine	IDA IDA: 通过直接分析推断	12205083	RGD
involved in cellular response to nitric oxide	IEP IEP: 通过表达模式推断	25100282	RGD
involved in centrosome cycle	IMP IMP: 通过突变表型推断	15048127	RGD
involved in macropinocytosis	IMP IMP: 通过突变表型推断	18003703	RGD
involved in membrane tubulation	IMP IMP: 通过突变表型推断	35620056	RGD
involved in negative regulation of non-motile cilium assembly	IMP IMP: 通过突变表型推断	23994472	RGD
involved in negative regulation of transforming growth factor beta receptor signaling pathway	IMP IMP: 通过突变表型推断	25100282	RGD
involved in neuron projection morphogenesis	IMP IMP: 通过突变表型推断	21210813	RGD
involved in positive regulation of P-type sodium:potassium-exchanging transporter activity	IMP IMP: 通过突变表型推断	12205083	RGD
involved in positive regulation of clathrin-dependent endocytosis	IMP IMP: 通过突变表型推断	11925437	RGD
involved in positive regulation of endocytosis	IMP IMP: 通过突变表型推断	18435821	RGD
involved in positive regulation of lamellipodium assembly	IMP IMP: 通过突变表型推断	14617821	RGD
involved in positive regulation of nitric oxide biosynthetic process	IMP IMP: 通过突变表型推断	16973909	RGD
involved in positive regulation of phagocytosis	IMP IMP: 通过突变表型推断	12802072	RGD
involved in positive regulation of substrate adhesion-dependent cell spreading	IMP IMP: 通过突变表型推断	14617821	RGD
involved in postsynaptic endocytosis	EXP EXP: 通过实验结果推断	31597090	RGD
involved in postsynaptic endocytosis	IDA IDA: 通过直接分析推断	31597090	RGD
involved in postsynaptic endocytosis	IMP IMP: 通过突变表型推断	31597090	RGD
involved in protein polymerization	IMP IMP: 通过突变表型推断	35620056	RGD
involved in receptor-mediated endocytosis	IDA IDA: 通过直接分析推断	11925437	RGD
involved in receptor-mediated endocytosis	IMP IMP: 通过突变表型推断	19995918	RGD
involved in regulation of Golgi organization	IMP IMP: 通过突变表型推断	20231454	RGD
involved in regulation of Rac protein signal transduction	IMP IMP: 通过突变表型推断	14617821	RGD
involved in regulation of axon extension	IMP IMP: 通过突变表型推断	21210813	RGD
involved in response to cocaine	IEP IEP: 通过表达模式推断	19562697	RGD
involved in response to light stimulus	IEP IEP: 通过表达模式推断	22666495	RGD
involved in spermatogenesis	IEP IEP: 通过表达模式推断	12199526	RGD
involved in stress fiber assembly	IMP IMP: 通过突变表型推断	35620056	RGD

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in Golgi membrane	IDA IDA: 通过直接分析推断	15821732	RGD
located in cell junction	IDA IDA: 通过直接分析推断	21210813	RGD
located in centrosome	IDA IDA: 通过直接分析推断	15048127	RGD
located in clathrin-coated endocytic vesicle	IDA IDA: 通过直接分析推断	11925437	RGD
located in clathrin-coated pit	IDA IDA: 通过直接分析推断	9725914	RGD
located in clathrin-coated vesicle	IDA IDA: 通过直接分析推断	9438853	RGD
located in endosome	IDA IDA: 通过直接分析推断	12802072	RGD
is active in glutamatergic synapse	EXP EXP: 通过实验结果推断	31597090	RGD
is active in glutamatergic synapse	IDA IDA: 通过直接分析推断	11583995	RGD
is active in glutamatergic synapse	IMP IMP: 通过突变表型推断	11583995	RGD
located in growth cone	IDA IDA: 通过直接分析推断	21210813	RGD
located in lamellipodium	IDA IDA: 通过直接分析推断	9725914	RGD
located in neuron projection	IDA IDA: 通过直接分析推断	11583995	RGD
located in perinuclear region of cytoplasm	IDA IDA: 通过直接分析推断	15126636	RGD
located in phagocytic cup	IDA IDA: 通过直接分析推断	12802072	RGD
located in postsynaptic density	IDA IDA: 通过直接分析推断	11583995	RGD
is active in postsynaptic density, intracellular component	IDA IDA: 通过直接分析推断	11583995	RGD
is active in postsynaptic density, intracellular component	IMP IMP: 通过突变表型推断	11583995	RGD
is active in postsynaptic endocytic zone	IDA IDA: 通过直接分析推断	35072626	RGD
is active in postsynaptic endocytic zone	IMP IMP: 通过突变表型推断	35072626	RGD
part of protein-containing complex	IDA IDA: 通过直接分析推断	17257598	RGD
located in ruffle membrane	IDA IDA: 通过直接分析推断	9725914	RGD
located in trans-Golgi network	IDA IDA: 通过直接分析推断	12802072	RGD

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

dynamin-2

Dnm2 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属间	Dnm2	P39052	SH3BP4	Homo sapiens	Q9P0V3	SPR	16325581
种属间	Dnm2	P39052	SH3BP4	Homo sapiens	Q9P0V3	Pull Down	16325581
种属间	Dnm2	P39052	SH3KBP1	Homo sapiens	Q96B97	Pull Down	20711168
种属间	Dnm2	P39052	SORBS1	Homo sapiens	Q9BX66	Pull Down	19116150
种属内	Dnm2	P39052	Shank1	Rattus norvegicus	Q9WV48	Anti Tag CoIP	11583995
种属内	Dnm2	P39052	Shank1	Rattus norvegicus	Q9WV48	Anti Bait CoIP	11583995

种属间: 跨种属相互作用 种属内: 同种属相互作用

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-132583	IONIS-DNM2-2.5Rx	Inhibitor	/	否
HY-132583A	IONIS-DNM2-2.5Rx sodium	Inhibitor	/	否
HY-RS03905	DNM2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Homo sapiens	Dnm2	NCBI	NCBI:1785

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2025 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

Dnm2 - dynamin 2 Gene

关于 Dnm2

功能概要

Dnm2 基因产物(1)

Dnm2 蛋白互作信息

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

姓名
邮箱 *

Sorry, but the email address you supplied was invalid.

Dnm2 - dynamin 2 Gene

关于 Dnm2

功能概要

Dnm2 基因产物(1)

Dnm2 蛋白互作信息

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z