2. Gene
  3. Shank1 - SH3 and multiple ankyrin repeat domains 1 Gene

Shank1 - SH3 and multiple ankyrin repeat domains 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: Spank1; Sstrip; Shank1a

基因 ID: 78957 | 基因类型: protein coding

关于 Shank1

功能概要

Enables several functions, including protein C-terminus binding activity; protein domain specific binding activity; and signaling receptor binding activity. Involved in positive regulation of dendritic spine development; protein-containing complex assembly; and synapse maturation. Located in dendritic spine; postsynaptic density; and postsynaptic membrane. Orthologous to human SHANK1 (SH3 and multiple ankyrin repeat domains 1). [provided by Alliance of Genome Resources, Apr 2022]

Shank1 基因产物(1)

mRNA Protein Name
NM_031751.4 NP_113939.2 SH3 and multiple ankyrin repeat domains protein 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables G protein-coupled receptor binding IPI
IPI: 通过物理相互作用推断
10958799 RGD
enables SH3 domain binding IPI
IPI: 通过物理相互作用推断
15496675 RGD
enables ankyrin repeat binding IPI
IPI: 通过物理相互作用推断
15496675 RGD
enables identical protein binding IPI
IPI: 通过物理相互作用推断
15496675 RGD
enables ionotropic glutamate receptor binding IPI
IPI: 通过物理相互作用推断
20171009 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
10433268 RGD
enables protein-containing complex binding IPI
IPI: 通过物理相互作用推断
11178875 RGD
enables scaffold protein binding IPI
IPI: 通过物理相互作用推断
10433269 RGD
enables signaling receptor complex adaptor activity IDA
IDA: 通过直接分析推断
10958799 RGD
enables somatostatin receptor binding IPI
IPI: 通过物理相互作用推断
10551867 RGD
enables synaptic receptor adaptor activity IDA
IDA: 通过直接分析推断
10433269 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of dendritic spine development IDA
IDA: 通过直接分析推断
18287537 RGD
involved in protein-containing complex assembly IDA
IDA: 通过直接分析推断
10433269 RGD
involved in synapse maturation IDA
IDA: 通过直接分析推断
18287537 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in dendritic spine IDA
IDA: 通过直接分析推断
15496675 RGD
located in postsynaptic density IDA
IDA: 通过直接分析推断
10433269 RGD
located in postsynaptic membrane IDA
IDA: 通过直接分析推断
10958799 RGD
located in synapse IDA
IDA: 通过直接分析推断
15496675 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

SH3 and multiple ankyrin repeat domains protein 1

GKAP/SAPAP-interacting protein

SAPAP-interacting protein synamon

SH3/ankyrin domain gene 1

SPANK-1

SSTR-interacting protein

somatostatin receptor-interacting protein

synamon

Shank1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra Shank1 Q9WV48 Sharpin Rattus norvegicus Q9EQL9
Confocal
11178875
Intra Shank1 Q9WV48 Sharpin Rattus norvegicus Q9EQL9
Y2H
11178875
Intra Shank1 Q9WV48 Sharpin Rattus norvegicus Q9EQL9
Anti Bait CoIP
11178875
Cross Shank1 Q9WV48 Grid2 Mus musculus Q61625
Pull Down
15207857
Intra Shank1 Q9WV48 Dlg4 Rattus norvegicus P31016
Anti Bait CoIP
10433268
Intra Shank1 Q9WV48 Dlgap1 Rattus norvegicus P97836-5
Pull Down
10433268
Intra Shank1 Q9WV48 Dlgap1 Rattus norvegicus P97836-5
Y2H
10433268
Intra Shank1 Q9WV48 Dlgap1 Rattus norvegicus P97836
CoIP
10488079
Intra Shank1 Q9WV48 Dlgap1 Rattus norvegicus P97836
Anti Bait CoIP
10433268
Cross Shank1 Q9WV48 Arhgef7 Mus musculus Q9ES28-2
Pull Down
12626503
Cross Shank1 Q9WV48 Arhgef7 Mus musculus Q9ES28-2
Y2H Array
12626503
Cross Shank1 Q9WV48 Arhgef7 Mus musculus Q9ES28-2
Anti Tag CoIP
12626503
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12850 SHANK1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Shank1 NCBI NCBI:50944
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