2. Gene
  3. ZFP36L1 - ZFP36 ring finger protein like 1 Gene

ZFP36L1 - ZFP36 ring finger protein like 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：ZFP36 无名指蛋白样 1

种属: Homo sapiens

同用名: BRF1; ERF1; cMG1; ERF-1; Berg36; TIS11B; RNF162B

基因 ID: 677 | 基因类型: protein coding

关于 ZFP36L1

Cytogenetic location: 14q24.1 Genomic coordinates (GRCh38): 14:68,787,655-68,796,243 (from NCBI)

This gene has 6 transcripts (splice variants), 247 orthologues and 2 paralogues. Ubiquitous expression in endometrium (RPKM 164.2), ovary (RPKM 123.6) and 25 other tissues.

功能概要

该基因是 TIS11 早期反应基因家族的成员，由佛波醇酯 TPA 和多肽促细胞分裂素 EGF 等各种激动剂诱导。该基因在所有物种中都非常保守，并且有一个启动子，其中包含在其他早期反应基因中看到的基序。编码的蛋白质包含一个有区别的推定锌指结构域和一个重复的 cys-his 基序。这种推定的核转录因子最有可能在调节对生长因子的反应中发挥作用。已发现该基因编码不同亚型的可变剪接转录物变体。[RefSeq 提供，2011 年 9 月]

This gene is a member of the TIS11 family of early response genes, which are induced by various agonists such as the phorbol ester TPA and the polypeptide mitogen EGF. This gene is well conserved across species and has a promoter that contains motifs seen in Other early-response genes. The encoded protein contains a distinguishing putative zinc finger domain with a repeating cys-his motif. This putative nuclear transcription factor most likely functions in regulating the response to growth factors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

ZFP36L1 基因产物(3)

mRNA Protein Name
NM_001244698.2 NP_001231627.1 mRNA decay activator protein ZFP36L1 isoform 1
NM_001244701.1 NP_001231630.1 mRNA decay activator protein ZFP36L1 isoform 2
NM_004926.4 NP_004917.2 mRNA decay activator protein ZFP36L1 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables 14-3-3 protein binding IDA
IDA: 通过直接分析推断
15538381 GOA
enables mRNA 3'-UTR AU-rich region binding IDA
IDA: 通过直接分析推断
12198173 GOA
enables mRNA binding IDA
IDA: 通过直接分析推断
15467755 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
15687258 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in 3'-UTR-mediated mRNA destabilization IDA
IDA: 通过直接分析推断
15467755 GOA
involved in 3'-UTR-mediated mRNA destabilization IMP
IMP: 通过突变表型推断
12198173 GOA
involved in ERK1 and ERK2 cascade IDA
IDA: 通过直接分析推断
25106868 GOA
involved in MAPK cascade IDA
IDA: 通过直接分析推断
18326031 GOA
involved in cellular response to cAMP IDA
IDA: 通过直接分析推断
19179481 GOA
involved in cellular response to epidermal growth factor stimulus IDA
IDA: 通过直接分析推断
20166898 GOA
involved in cellular response to glucocorticoid stimulus IDA
IDA: 通过直接分析推断
20166898 GOA
involved in cellular response to hypoxia IMP
IMP: 通过突变表型推断
21832157 GOA
involved in cellular response to insulin stimulus IDA
IDA: 通过直接分析推断
15538381 GOA
involved in cellular response to peptide hormone stimulus IDA
IDA: 通过直接分析推断
15467755 GOA
involved in cellular response to transforming growth factor beta stimulus IDA
IDA: 通过直接分析推断
20166898 GOA
involved in cellular response to tumor necrosis factor IDA
IDA: 通过直接分析推断
20166898 GOA
involved in mRNA transport IMP
IMP: 通过突变表型推断
17369404 GOA
involved in negative regulation of erythrocyte differentiation IDA
IDA: 通过直接分析推断
20702587 GOA
involved in phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
IDA: 通过直接分析推断
15538381 GOA
involved in positive regulation of intracellular mRNA localization IMP
IMP: 通过突变表型推断
17369404 GOA
involved in positive regulation of monocyte differentiation IDA
IDA: 通过直接分析推断
26542173 GOA
involved in regulation of gene expression IDA
IDA: 通过直接分析推断
20166898 GOA
involved in regulation of keratinocyte apoptotic process IMP
IMP: 通过突变表型推断
27182009 GOA
involved in regulation of keratinocyte differentiation IMP
IMP: 通过突变表型推断
27182009 GOA
involved in regulation of keratinocyte proliferation IMP
IMP: 通过突变表型推断
27182009 GOA
involved in regulation of mRNA 3'-end processing IDA
IDA: 通过直接分析推断
21832157 GOA
acts upstream of or within regulation of mRNA stability IDA
IDA: 通过直接分析推断
15467755 GOA
involved in regulation of mRNA stability IDA
IDA: 通过直接分析推断
15538381 GOA
involved in regulation of mRNA stability IMP
IMP: 通过突变表型推断
12198173 GOA
involved in response to wounding IDA
IDA: 通过直接分析推断
27182009 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in P-body IDA
IDA: 通过直接分析推断
17369404 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
12198173 GOA
located in nucleus IDA
IDA: 通过直接分析推断
12198173 GOA
part of ribonucleoprotein complex IDA
IDA: 通过直接分析推断
15687258 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ZFP36L1 蛋白结构

Tis11B_N

Tis11B_N: Tis11B like protein, N terminus (1 - 107)

zf-CCCH

zf-CCCH: Zinc finger C-x8-C-x5-C-x3-H type (and similar) (115 - 140)

zf-CCCH

zf-CCCH: Zinc finger C-x8-C-x5-C-x3-H type (and similar) (153 - 178)

  • 0
  • 100
  • 200
  • 300
  • 338 a.a.
蛋白主名 其他名称

mRNA decay activator protein ZFP36L1

EGF-response factor 1

ZFP36L1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
ZFP36L1 Q07352 YWHAG Homo sapiens P61981
SLC
36931259
种属内
ZFP36L1 Q07352 MAPK14 Homo sapiens Q16539
Y2H Pooling
16189514
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
T-Cell Acute Lymphoblastic Leukemia

T-Cell Leukemia

Acute T Cell Leukemia

Precursor T Lymphoblastic Leukemia

Precursor T-Lymphoblastic Lymphoma/Leukemia

T Acute Lymphoblastic Leukemia

T-Cell Acute Lymphocytic Leukaemia

T-Cell Lymphoblastic Leukemia/Lymphoma

Leukemia T-Cell

Leukemia, T-Cell

Leukemia, Acute, Lymphoblastic, T-Cell

Leukemia, T-Cell Acute Lymphoblastic

Leukemia, Acute T-Cell

Precursor T-Cell Lymphoblastic Leukemia-Lymphoma

Precursor T-Cell Lymphoblastic Lymphoma

Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS16041 ZFP36L1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta ZFP36L1 VGNC VGNC:99347
Canis familiaris ZFP36L1 VGNC VGNC:48613
Mus musculus ZFP36L1 MGD MGI:107946
Felis catus ZFP36L1 VGNC VGNC:67231
Bos taurus ZFP36L1 VGNC VGNC:37163
Rattus norvegicus ZFP36L1 RGD RGD:62009
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z