WWTR1 - WW domain containing transcription regulator 1 Gene

中文名称：含 WW 结构域的转录因子 1

种属: Homo sapiens

同用名: TAZ

基因 ID: 25937 | 基因类型: protein coding

关于 WWTR1

Cytogenetic location: 3q25.1 Genomic coordinates (GRCh38): 3:149,517,235-149,724,788 (from NCBI)

This gene has 12 transcripts (splice variants), 160 orthologues, 1 paralogue and is associated with 64 phenotypes. Ubiquitous expression in gall bladder (RPKM 24.8), endometrium (RPKM 22.7) and 24 other tissues.

功能概要

启用转录共激活因子活性。涉及多个过程，包括河马信号；细胞分化的正调控；和信号转导的调节。位于细胞质和核体中。 [由基因组资源联盟提供，2022 年 4 月]

Enables transcription coactivator activity. Involved in several processes, including hippo signaling; positive regulation of cell differentiation; and regulation of signal transduction. Located in cytosol and nuclear body. [provided by Alliance of Genome Resources, Apr 2022]

WWTR1 基因产物(4)

mRNA	Protein	Name
NM_001168278.3	NP_001161750.1	WW domain-containing transcription regulator protein 1
NM_001168280.3	NP_001161752.1	WW domain-containing transcription regulator protein 1
NM_001348362.2	NP_001335291.1	WW domain-containing transcription regulator protein 1
NM_015472.6	NP_056287.1	WW domain-containing transcription regulator protein 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	16099986	GOA
enables transcription coactivator activity	IDA IDA: 通过直接分析推断	19010321	GOA
enables transcription coactivator activity	IMP IMP: 通过突变表型推断	23911299	GOA
enables transcription coregulator activity	IDA IDA: 通过直接分析推断	19010321	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in SMAD protein signal transduction	IDA IDA: 通过直接分析推断	18568018	GOA
involved in hippo signaling	IDA IDA: 通过直接分析推断	18227151	GOA
involved in negative regulation of canonical Wnt signaling pathway	IMP IMP: 通过突变表型推断	20412773	GOA
involved in negative regulation of fat cell differentiation	IGI IGI: 通过遗传相互作用推断	29496737	GOA
involved in negative regulation of protein kinase activity	IMP IMP: 通过突变表型推断	20412773	GOA
involved in negative regulation of protein phosphorylation	IMP IMP: 通过突变表型推断	20412773	GOA
involved in positive regulation of cell population proliferation	IDA IDA: 通过直接分析推断	18227151	GOA
involved in positive regulation of epithelial to mesenchymal transition	IDA IDA: 通过直接分析推断	18227151	GOA
involved in positive regulation of osteoblast differentiation	IGI IGI: 通过遗传相互作用推断	29496737	GOA
involved in stem cell division	IDA IDA: 通过直接分析推断	18568018	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	20412773	GOA
is active in nucleus	IDA IDA: 通过直接分析推断	19010321	GOA
located in nucleus	IDA IDA: 通过直接分析推断	18568018	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

WWTR1 蛋白结构

0
100
200
300
400 a.a.

蛋白主名

其他名称

WW domain-containing transcription regulator protein 1

transcriptional co-activator with PDZ-binding motif

WWTR1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	WWTR1	Q9GZV5	TCP11L1	Homo sapiens	Q9NUJ3	Validated Y2H	32296183
种属内	WWTR1	Q9GZV5	BTRC	Homo sapiens	Q9Y297	Anti Tag CoIP	33961781
种属内	WWTR1	Q9GZV5	CCAR1	Homo sapiens	Q8IX12	Anti Bait CoIP	20594350
种属内	WWTR1	Q9GZV5	YWHAE	Homo sapiens	P62258	Y2H Pooling	20936779
种属内	WWTR1	Q9GZV5	YWHAE	Homo sapiens	P62258	CoIP	16099986
种属内	WWTR1	Q9GZV5	YWHAE	Homo sapiens	P62258	Anti Tag CoIP	33961781
种属内	WWTR1	Q9GZV5	SCRIB	Homo sapiens	Q14160	Anti Bait CoIP	22078877
种属内	WWTR1	Q9GZV5	YWHAG	Homo sapiens	P61981	Anti Tag CoIP	33961781
种属内	WWTR1	Q9GZV5	LATS1	Homo sapiens	O95835	Anti Bait CoIP	22078877
种属内	WWTR1	Q9GZV5	CTNNB1	Homo sapiens	P35222	Anti Bait CoIP	23245942
种属内	WWTR1	Q9GZV5	CTNNB1	Homo sapiens	P35222	Anti Tag CoIP	22234184
种属内	WWTR1	Q9GZV5	DVL1	Homo sapiens	O14640	Lumier	20412773
种属内	WWTR1	Q9GZV5	WBP2	Homo sapiens	Q969T9	Anti Tag CoIP	20972459
种属内	WWTR1	Q9GZV5	WBP2	Homo sapiens	Q969T9	Pull Down	20972459
种属内	WWTR1	Q9GZV5	DVL2	Homo sapiens	O14641	Lumier	20412773
种属内	WWTR1	Q9GZV5	DVL2	Homo sapiens	O14641	Anti Bait CoIP	20412773
种属内	WWTR1	Q9GZV5	TEAD3	Homo sapiens	Q99594	Anti Tag CoIP	28514442
种属内	WWTR1	Q9GZV5	TEAD3	Homo sapiens	Q99594	Anti Tag CoIP	33961781

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Epithelioid Hemangioendothelioma

Hemangioendothelioma Epithelioid

Epithelioid Hemangioendothelioma, Malignant

Malignant Epithelioid Hemangioendothelioma

Epithelioid Hemangioendothelioma, Malignant

Histiocytoid Hemangioma

Angiolymphoid Hyperplasia With Eosinophilia	Epithelioid Haemangioma
Epithelioid Hemangioma

Hemangioendothelioma

Malignant Hemangioma

Sveinsson Chorioretinal Atrophy

SCRA	Atrophia Areata
Helicoid Peripapillary Chorioretinal Degeneration	Hpcd
Aa	Peripapillary Chorioretinal Degeneration, Icelandic Type
Helicoidal Peripapillary Chorioretinal Degeneration	Atrophy, Chorioretinal, Sveinsson

Eccrine Acrospiroma

Acrospiroma	Poroma
Eccrine Hidradenoma	Eccrine Hidradenoma Of Skin
Hidradenoma	Adenoma, Sweat Gland
Benign Neoplasm Of Sweat Gland	Eccrine Poroma

Eccrine Sweat Gland Neoplasm

Eccrine Skin Neoplasm	Eccrine Tumor
Eccrine Neoplasm	Malignant Eccrine Neoplasm

Choroid Plexus Meningioma

Choroid Meningioma

Meningioma Of The Choroid Plexus

Eccrine Porocarcinoma

Porocarcinoma	Eccrine Porocarcinoma Of Skin
Malignant Eccrine Poroma

Eccrine Sweat Gland Cancer

Malignant Eccrine Skin Neoplasm

Malignant Eccrine Tumor

Intestinal Obstruction

Inspissated Milk Syndrome

Milk Curd Syndrome

Childhood Angiosarcoma

Paediatric Angiosarcoma	Paediatric Hemangiosarcoma
Pediatric Angiosarcoma	Pediatric Hemangiosarcoma

Vascular Cancer

Blood Vessel Tumors	Malignant Vascular Neoplasm
Renal Vein Leiomyosarcoma	Vascular Neoplasms
Blood Vessel Neoplasm	Blood Vessel Tumor
Blood Vessel Tumour Disorder	Haemangiomatous Tumour
Leiomyosarcoma Of The Renal Vein	Malignant Great Vessel Tumor
Malignant Tumor Of Pulmonary Artery	Malignant Tumor Of Pulmonary Vein
Malignant Vascular Tumor	Neoplasm Of Great Vessel
Pulmonary Artery Malignant Neoplasm	Pulmonary Vein Malignant Neoplasm
Vascular Tissue Neoplasm	Vascular Tumors
Blood Vessel Cancer	Neoplasms, Vascular Tissue
Malignant Neoplasm Of Great Vessels

Neurofibromatosis, Type Ii

Neurofibromatosis 2	Neurofibromatosis, Type 2
NF2	Neurofibromatosis Type Ii
Bilateral Acoustic Neurofibromatosis	Banf
Acn	Central Neurofibromatosis
Neurofibromatosis, Central Type	Acoustic Schwannomas, Bilateral
Acoustic Neurinoma, Bilateral	Bilateral Acoustic Neurinoma
Bilateral Acoustic Schwannomas	Familial Acoustic Neuromas

Cerebral Cavernous Malformations

Cerebral Cavernous Malformation	Cavernous Malformations Of Cns And Retina
Cerebral Cavernous Malformation 1	Cavernous Angiomatous Malformations
Cerebral Capillary Malformations	CCM
Hyperkeratotic Cutaneous Capillary-Venous Malformations Associated With Cerebral Capillary Malformations	Familial Cavernous Angioma
Cavernous Angioma	Familial Cerebral Cavernous Malformation
Cerebral Cavernous Malformations 1	Cavernous Angioma, Familial
Cam	Cerebral Cavernous Malformations-1
Cavernoma	Central Nervous System Cavernous Hemangioma
Cerebral Cavernous Hemangioma	Familial Cavernous Hemangioma
Familial Cavernous Malformation	Familial Cerebral Cavernous Angioma
Intracerebral Cavernous Hemangioma	CCM1
Cavernous Hemangioma Of The Brain	Cerebral Cavernoma
Cerebral Cavernous Malformations, Type 1	Hemangioma, Cavernous, Central Nervous System
Hemangioma, Cavernous	Angioma, Cavernous

Rhabdomyosarcoma

Sclerosing Hepatic Carcinoma

Sclerosing Hepatocellular Carcinoma

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS16236	Wwtr1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS15862	WWTR1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	WWTR1	RGD	RGD:1559609
Mus musculus	WWTR1	MGD	MGI:1917649
Canis familiaris	WWTR1	VGNC	VGNC:52910
Macaca mulatta	WWTR1	VGNC	VGNC:79415
Felis catus	WWTR1	VGNC	VGNC:102868
Bos taurus	WWTR1	VGNC	VGNC:36980

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