LATS1 - large tumor suppressor kinase 1 Gene

中文名称：大肿瘤抑制激酶 1

种属: Homo sapiens

同用名: wts; WARTS

基因 ID: 9113 | 基因类型: protein coding

关于 LATS1

Cytogenetic location: 6q25.1 Genomic coordinates (GRCh38): 6:149,658,153-149,718,101 (from NCBI)

This gene has 7 transcripts (splice variants), 210 orthologues, 13 paralogues and is associated with 96 phenotypes. Ubiquitous expression in ovary (RPKM 6.7), endometrium (RPKM 5.8) and 25 other tissues.

功能概要

由该基因编码的蛋白质是一种推定的丝氨酸/苏氨酸激酶，定位于有丝分裂器并在早期有丝分裂中与细胞周期控制器 CDC2 激酶复合。蛋白质以细胞周期依赖性方式磷酸化，后期磷酸化一直保持到中期。该蛋白的 N 端区域结合 CDC2 形成复合物，显示 H1 组蛋白激酶活性降低，表明其作为 CDC2/细胞周期蛋白 A 的负调节剂。此外，C 端激酶结构域与其自身的 N 端结合区域，表明通过分子内结合干扰复杂形成的潜在负调节。生化和遗传数据表明它具有肿瘤抑制因子的作用。这得到了敲除小鼠研究的支持，这些研究表明软组织肉瘤、卵巢间质细胞瘤的发展以及对致癌治疗的高度敏感性。[RefSeq 提供，2017 年 4 月]

The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments. [provided by RefSeq, Apr 2017]

LATS1 基因产物(5)

mRNA	Protein	Name
NM_001270519.2	NP_001257448.1	serine/threonine-protein kinase LATS1 isoform 2
NM_001350339.2	NP_001337268.1	serine/threonine-protein kinase LATS1 isoform 3
NM_001350340.2	NP_001337269.1	serine/threonine-protein kinase LATS1 isoform 4
NM_001350392.2	NP_001337321.1	serine/threonine-protein kinase LATS1 isoform 5
NM_004690.4	NP_004681.1	serine/threonine-protein kinase LATS1 isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables ATP binding	IDA IDA: 通过直接分析推断	10518011	GOA
enables magnesium ion binding	IDA IDA: 通过直接分析推断	10518011	GOA
enables nuclear estrogen receptor binding	IPI IPI: 通过物理相互作用推断	28068668	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	9988268	GOA
enables protein kinase binding	IPI IPI: 通过物理相互作用推断	19927127	GOA
enables protein serine/threonine kinase activity	IDA IDA: 通过直接分析推断	10518011	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in G2/M transition of mitotic cell cycle	IDA IDA: 通过直接分析推断	15122335	GOA
involved in cytoplasmic sequestering of protein	IMP IMP: 通过突变表型推断	20412773	GOA
involved in hippo signaling	IDA IDA: 通过直接分析推断	20412773	GOA
involved in mammary gland epithelial cell differentiation	IMP IMP: 通过突变表型推断	28068668	GOA
involved in negative regulation of canonical Wnt signaling pathway	IMP IMP: 通过突变表型推断	20412773	GOA
involved in negative regulation of cyclin-dependent protein serine/threonine kinase activity	IDA IDA: 通过直接分析推断	9988268	GOA
involved in positive regulation of peptidyl-serine phosphorylation	IDA IDA: 通过直接分析推断	20412773	GOA
involved in protein phosphorylation	IDA IDA: 通过直接分析推断	10518011	GOA
involved in regulation of actin filament polymerization	IDA IDA: 通过直接分析推断	15220930	GOA
involved in regulation of intracellular estrogen receptor signaling pathway	IMP IMP: 通过突变表型推断	28068668	GOA
involved in regulation of protein-containing complex assembly	IMP IMP: 通过突变表型推断	20412773	GOA
involved in regulation of ubiquitin-dependent protein catabolic process	IMP IMP: 通过突变表型推断	28068668	GOA
involved in sister chromatid segregation	IDA IDA: 通过直接分析推断	15122335	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
is active in cytoplasm	IDA IDA: 通过直接分析推断	35429439	GOA
located in spindle pole	IDA IDA: 通过直接分析推断	10518011	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

LATS1 蛋白结构

UBA

Pkinase

0
200
400
600
800
1000
1130 a.a.

蛋白主名

其他名称

serine/threonine-protein kinase LATS1

LATS (large tumor suppressor, Drosophila) homolog 1

LATS1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	LATS1	O95835	NF2	Homo sapiens	P35240	Anti Tag CoIP	24012335
Intra	LATS1	O95835	NF2	Homo sapiens	P35240	IF	24012335
Intra	LATS1	O95835	YAP1	Homo sapiens	P46937	ITC	25283809
Intra	LATS1	O95835	NUAK1	Homo sapiens	O60285	Anti Bait CoIP	19927127
Intra	LATS1	O95835	DCAF1	Homo sapiens	Q9Y4B6	Anti Tag CoIP	25026211
Intra	LATS1	O95835	MOB1B	Homo sapiens	Q7L9L4	Pull Down	19739119
Intra	LATS1	O95835	CDK2	Homo sapiens	P24941	Anti Bait CoIP	25218637
Intra	LATS1	O95835	ZYX	Homo sapiens	Q15942	CoIP	10831611
Intra	LATS1	O95835	ZYX	Homo sapiens	Q15942	Imaging	10831611
Intra	LATS1	O95835	ZYX	Homo sapiens	Q15942	Pull Down	10831611
Intra	LATS1	O95835	CDK1	Homo sapiens	P06493	Y2H	9988268
Intra	LATS1	O95835	CDK1	Homo sapiens	P06493	Anti Bait CoIP	25218637
Intra	LATS1	O95835	LIMK1	Homo sapiens	P53667	Pull Down	15220930
Intra	LATS1	O95835	LIMK1	Homo sapiens	P53667	CoIP	15220930
Intra	LATS1	O95835	WWTR1	Homo sapiens	Q9GZV5	Anti Bait CoIP	20412773
Intra	LATS1	O95835	WWTR1	Homo sapiens	Q9GZV5	Anti Bait CoIP	22078877
Intra	LATS1	O95835	MOB1A	Homo sapiens	Q9H8S9	Anti Tag CoIP	19739119
Intra	LATS1	O95835	MOB1A	Homo sapiens	Q9H8S9	Pull Down	19739119
Intra	LATS1	O95835	ESR1	Homo sapiens	P03372	Anti Bait CoIP	28068668

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Malignant Peritoneal Mesothelioma

Diffuse Malignant Peritoneal Mesothelioma	Primary Malignant Peritoneal Mesothelioma
Malignant Mesothelioma Of Peritoneum

Tetraploidy

Tetraploidy Syndrome

Plasma Cell Neoplasm

Plasma Cell Dyscrasia	Paraproteinemias
Plasma Cell Tumour	Plasmacytic Tumor
Multiple Myeloma	Plasmacytoma
Plasma Cell Tumours	Plasma Cells Dyscrasia

Myeloma, Multiple

Multiple Myeloma	Plasma Cell Myeloma
Kahler Disease	Myelomatosis
Medullary Plasmacytoma	Multiple Myeloma, Resistance To
Myeloma	Plasma Cell Dyscrasia
Kahler'S Disease	Multiple Myeloma, Susceptibility To
Myeloma - Multiple	Kahler-Bozzolo Disease
Plasma Cell Myelomas	MM
Plasma Cell Neoplasm	Primary Systemic Amyloidosis
Primary Amyloidosis	Immunoglobulin Deposition Disease
Plasmacytic Myeloma	Multiple Myelomata
Multiple Myeloma Nos	Multiple Myeloma Without Mention Of Remission
Monostotic Plasma Cell Myeloma	Mm - [Multiple Myeloma]

Neurofibromatosis, Type Ii

Neurofibromatosis 2	Neurofibromatosis, Type 2
NF2	Neurofibromatosis Type Ii
Bilateral Acoustic Neurofibromatosis	Banf
Acn	Central Neurofibromatosis
Neurofibromatosis, Central Type	Acoustic Schwannomas, Bilateral
Acoustic Neurinoma, Bilateral	Bilateral Acoustic Neurinoma
Bilateral Acoustic Schwannomas	Familial Acoustic Neuromas

Microphthalmia, Syndromic 10

MCOPS10	Moba
Microphthalmia And Brain Atrophy	Syndromic Microphthalmia 10
Microphthalmia-Brain Atrophy Syndrome	Microphthalmia Syndromic 10
Moba Syndrome	Syndromic Microphthalmia Type 10

Metatypical Basal Cell Carcinoma

Skin Metatypical Carcinoma	Basosquamous Carcinoma Of Skin
Skin Metatypical Basal Cell Carcinoma

Sveinsson Chorioretinal Atrophy

SCRA	Atrophia Areata
Helicoid Peripapillary Chorioretinal Degeneration	Hpcd
Aa	Peripapillary Chorioretinal Degeneration, Icelandic Type
Helicoidal Peripapillary Chorioretinal Degeneration	Atrophy, Chorioretinal, Sveinsson

Melanoma, Uveal

Uveal Melanoma	Choroidal Melanoma
Melanoma Of Uvea	Iris Melanoma
Malignant Melanoma Of Choroid	Malignant Melanoma Of Iris

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-138489	TRULI	Modulator	99.98%	否
HY-108540	BCH	Inducer	99.13%	否
HY-147082	GA-017	Activator	98.92%	否
HY-W011391	GPNA hydrochloride		99.91%	否
HY-139330	MGH-CP1	Inducer	99.21%	否
HY-147165	VT02956	Inhibitor	99.58%	否
HY-120139	KMH-233	Inhibitor	98.11%	否
HY-120139A	(R)-KMH-233		/	否
HY-RS07538	LATS1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-147165A	VT02956 hydrochloride	Inhibitor	/	否
HY-164401	QBS10072S		/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	LATS1	VGNC	VGNC:74238
Felis catus	LATS1	VGNC	VGNC:68021
Canis familiaris	LATS1	VGNC	VGNC:42598
Bos taurus	LATS1	VGNC	VGNC:30800
Rattus norvegicus	LATS1	RGD	RGD:1564085
Mus musculus	LATS1	MGD	MGI:1333883
Others	LATS1	NCBI

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2024 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

LATS1 - large tumor suppressor kinase 1 Gene

关于 LATS1

功能概要

LATS1 基因产物(5)

LATS1 蛋白结构

LATS1 蛋白互作信息

关联疾病

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

姓名
邮箱 *

Sorry, but the email address you supplied was invalid.

LATS1 - large tumor suppressor kinase 1 Gene

关于 LATS1

功能概要

LATS1 基因产物(5)

LATS1 蛋白结构

LATS1 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z