2. Gene
  3. NUAK1 - NUAK family kinase 1 Gene

NUAK1 - NUAK family kinase 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：NUAK 家族激酶 1

种属: Homo sapiens

同用名: ARK5

基因 ID: 9891 | 基因类型: protein coding

关于 NUAK1

Cytogenetic location: 12q23.3 Genomic coordinates (GRCh38): 12:106,063,345-106,138,954 (from NCBI)

This gene has 4 transcripts (splice variants), 257 orthologues and 17 paralogues. Broad expression in brain (RPKM 19.6), skin (RPKM 9.2) and 19 other tissues.

功能概要

启用 p53 结合活性和蛋白丝氨酸/苏氨酸激酶活性。参与多个过程，包括蛋白质磷酸化；细胞衰老的调节；和肌球蛋白轻链磷酸酶活性的调节。位于细胞质中；微管细胞骨架；和核腔。 [由基因组资源联盟提供，2022 年 4 月]

Enables p53 binding activity and protein serine/threonine kinase activity. Involved in several processes, including protein phosphorylation; regulation of cellular senescence; and regulation of myosin-light-chain-phosphatase activity. Located in cytoplasm; microtubule cytoskeleton; and nuclear lumen. [provided by Alliance of Genome Resources, Apr 2022]

NUAK1 基因产物(1)

mRNA Protein Name
NM_014840.3 NP_055655.1 NUAK family SNF1-like kinase 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables p53 binding IPI
IPI: 通过物理相互作用推断
21317932 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16306228 GOA
enables protein serine/threonine kinase activity IDA
IDA: 通过直接分析推断
19927127 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in protein phosphorylation IDA
IDA: 通过直接分析推断
25329316 GOA
involved in regulation of cell adhesion IDA
IDA: 通过直接分析推断
20354225 GOA
involved in regulation of cellular senescence IDA
IDA: 通过直接分析推断
19927127 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
21317932 GOA
located in nucleus IDA
IDA: 通过直接分析推断
21317932 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NUAK1 蛋白结构

Pkinase

Pkinase: Protein kinase domain (55 - 305)

  • 0
  • 200
  • 400
  • 600
  • 661 a.a.
蛋白主名 其他名称

NUAK family SNF1-like kinase 1

AMP-activated protein kinase family member 5

AMPK-related protein kinase 5

NUAK family, SNF1-like kinase, 1

omphalocele kinase 1

NUAK1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra NUAK1 O60285 SRRM2 Homo sapiens Q9UQ35
Anti Tag CoIP
25852190
Intra NUAK1 O60285 SRRM2 Homo sapiens Q9UQ35
Pull Down
32707033
Intra NUAK1 O60285 USP9X Homo sapiens Q93008
TAP
16306228
Intra NUAK1 O60285 USP9X Homo sapiens Q93008
Pull Down
32707033
Intra NUAK1 O60285 TP53 Homo sapiens P04637
Protein Kinase Assay
21317932
Intra NUAK1 O60285 TP53 Homo sapiens P04637
CH-IP
21317932
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Omphalocele

Omphalocoele

Congenital Omphalocele

Exomphalos

Exumbilication
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon
Endometrial Squamous Cell Carcinoma

Squamous Cell Carcinoma Of Endometrium
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-12624 Narazaciclib Inhibitor 99.12% Phase 2
Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-12334 HTH-01-015 Inhibitor 98.81% 否
HY-15802 WZ4003 Inhibitor 98.03% 否
HY-120877 MRT199665 Inhibitor 99.74% 否
HY-153103 LRRK2/NUAK1/TYK2-IN-1 Inhibitor / 否
HY-153058 LRRK2-IN-8 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta NUAK1 VGNC VGNC:75403
Rattus norvegicus NUAK1 RGD RGD:1309956
Bos taurus NUAK1 VGNC VGNC:50006
Mus musculus NUAK1 MGD MGI:1925226
Canis familiaris NUAK1 VGNC VGNC:54977
Others NUAK1 NCBI
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