DCAF1 - DDB1 and CUL4 associated factor 1 Gene

中文名称：DDB1 和 CUL4 相关因子 1

种属: Homo sapiens

同用名: RIP; VPRBP

基因 ID: 9730 | 基因类型: protein coding

关于 DCAF1

Cytogenetic location: 3p21.2 Genomic coordinates (GRCh38): 3:51,395,867-51,505,639 (from NCBI)

This gene has 4 transcripts (splice variants) and 254 orthologues. Broad expression in testis (RPKM 27.5), thyroid (RPKM 8.3) and 24 other tissues.

功能概要

启用雌激素受体结合活性和组蛋白激酶活性 (H2A-T120 特异性) 。参与多细胞生物体的细胞竞争；组蛋白 H2A-T120 磷酸化； RNA 聚合酶 II 对转录的负调控。位于纤维中心和核质中。 Cul4-RING E3 泛素连接酶复合物的一部分。与 COP9 信号体共定位。 [由基因组资源联盟提供，2022 年 4 月]

Enables Estrogen Receptor binding activity and histone kinase activity (H2A-T120 specific). Involved in cell competition in a multicellular organism; histone H2A-T120 phosphorylation; and negative regulation of transcription by RNA polymerase II. Located in fibrillar center and nucleoplasm. Part of Cul4-RING E3 ubiquitin Ligase complex. Colocalizes with COP9 signalosome. [provided by Alliance of Genome Resources, Apr 2022]

DCAF1 基因产物(12)

mRNA	Protein	Name
NM_001171904.2	NP_001165375.1	DDB1- and CUL4-associated factor 1 isoform 2
NM_001349168.2	NP_001336097.1	DDB1- and CUL4-associated factor 1 isoform 1
NM_001349169.2	NP_001336098.1	DDB1- and CUL4-associated factor 1 isoform 1
NM_001349170.2	NP_001336099.1	DDB1- and CUL4-associated factor 1 isoform 1
NM_001349171.2	NP_001336100.1	DDB1- and CUL4-associated factor 1 isoform 3
NM_001387578.1	NP_001374507.1	DDB1- and CUL4-associated factor 1 isoform 1
NM_001387579.1	NP_001374508.1	DDB1- and CUL4-associated factor 1 isoform 1
NM_001387580.1	NP_001374509.1	DDB1- and CUL4-associated factor 1 isoform 1
NM_001387581.1	NP_001374510.1	DDB1- and CUL4-associated factor 1 isoform 1
NM_001387582.1	NP_001374511.1	DDB1- and CUL4-associated factor 1 isoform 2
NM_001387583.1	NP_001374512.1	DDB1- and CUL4-associated factor 1 isoform 3
NM_014703.3	NP_055518.1	DDB1- and CUL4-associated factor 1 isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables histone H2AT120 kinase activity	IDA IDA: 通过直接分析推断	24140421	GOA
enables nuclear estrogen receptor binding	IPI IPI: 通过物理相互作用推断	28068668	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	16949367	GOA
enables ubiquitin-like ligase-substrate adaptor activity	IDA IDA: 通过直接分析推断	23063525	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in cell competition in a multicellular organism	IMP IMP: 通过突变表型推断	20644714	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	24140421	GOA
involved in positive regulation of protein catabolic process	IDA IDA: 通过直接分析推断	23063525	GOA
involved in post-translational protein modification	IDA IDA: 通过直接分析推断	24140421	GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process	IDA IDA: 通过直接分析推断	28242748	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of COP9 signalosome	IDA IDA: 通过直接分析推断	18850735	GOA
part of Cul4-RING E3 ubiquitin ligase complex	IDA IDA: 通过直接分析推断	16949367	GOA
is active in centrosome	IDA IDA: 通过直接分析推断	28242748	GOA
located in nucleus	IDA IDA: 通过直接分析推断	20178741	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

DDB1- and CUL4-associated factor 1

HIV-1 Vpr-binding protein

DCAF1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	DCAF1	Q9Y4B6	DDB1	Homo sapiens	Q16531	Density Sedimentation	24412650
Intra	DCAF1	Q9Y4B6	LATS2	Homo sapiens	Q9NRM7	Anti Tag CoIP	25026211
Intra	DCAF1	Q9Y4B6	LATS2	Homo sapiens	Q9NRM7	Ubiquitinase Assay	25026211
Intra	DCAF1	Q9Y4B6	LATS1	Homo sapiens	O95835	Anti Tag CoIP	25026211
Intra	DCAF1	Q9Y4B6	LATS1	Homo sapiens	O95835	Pull Down	25026211
Intra	DCAF1	Q9Y4B6	LATS1	Homo sapiens	O95835	Ubiquitinase Assay	25026211
Cross	DCAF1	Q9Y4B6	a0a0h3lac5_mycte	Mycobacterium tuberculosis	A0A0H3LAC5	Anti Bait CoIP	30118682
Cross	DCAF1	Q9Y4B6	vpr	Human immunodeficiency virus	P12520	Pull Down	22190034
Cross	DCAF1	Q9Y4B6	vpx	Human immunodeficiency virus	P18045	Anti Tag CoIP	19264781
Cross	DCAF1	Q9Y4B6	vpx	Simian immunodeficiency virus	P19508	GMS	24336198
Cross	DCAF1	Q9Y4B6	vpx	Simian immunodeficiency virus	P19508	X-Ray Diffraction	24336198
Cross	DCAF1	Q9Y4B6	vpx	Simian immunodeficiency virus	P19508	Anti Tag CoIP	19264781

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Intraorbital Meningioma

Neurilemmomatosis

Schwannomatosis	Neurofibromatosis Type 3
Nf3	Neurilemmomatosis Congenital Cutaneous
Neurinomatosis	Congenital Cutaneous Neurilemmomatosis
Multiple Neurilemmomas	Multiple Schwannomas
Neurilemmomatosis, Congenital Cutaneous	Schwannomatosis 1
Neurofibromatosis 3	Mixed Central And Peripheral Neurofibromatosis
Nf3 - [Neurofibromatosis Type 3]

Meningioma, Familial

Meningioma	Familial Meningioma
Meningioma, Familial, Susceptibility To	Meningeal Neoplasm
Meningeal Neoplasms	Meningiomas
Meningioma, Nf2-Related, Somatic	Meningioma, Sis-Related
Meningothelial Cell Tumor	Neoplasm Of The Meninges
Primary Meningeal Tumor	Familial Multiple Meningioma
MNGMA	Meningioma, Benign, No Icd-O Subtype
Intracranial Meningioma	Meningothelial Cell Neoplasm
Supratentorial Meningioma	Primary Neoplasm Of Spinal Meninges
Benign Intracranial Meningioma	Benign Meningioma
Meningeal Tumours	Meningeal Sarcoma Of Unspecified Site
Meningothelial Sarcoma Of Unspecified Site

Acoustic Neuroma

Neurofibromatosis Type 2	Vestibular Schwannoma
Acoustic Neurinoma	Bilateral Acoustic Neurofibromatosis
Nf2	Acoustic Neurilemoma
Cerebellopontine Angle Tumor	Neurofibromatosis Central Type
Neurofibromatosis Type Ii	Vestibular Neurilemmoma
Acoustic Tumor	Neurinoma Of The Acoustic Nerve
Acoustic Neurinoma Bilateral	Acoustic Schwannomas Bilateral
Banf	Central Neurofibromatosis
Familial Acoustic Neuromas	Neurofibromatosis 2
Neurofibromatosis Type 2 Merlin	Schwannoma, Acoustic, Bilateral
Neuroma Acoustic	Neuroma, Acoustic
Familial Acoustic Neuroma	Familial Vestibular Schwannoma
Neurofibromatosis, Central Type	Nf2 - [Neurofibromatosis Type 2]

Neurofibromatosis, Type Ii

Neurofibromatosis 2	Neurofibromatosis, Type 2
NF2	Neurofibromatosis Type Ii
Bilateral Acoustic Neurofibromatosis	Banf
Acn	Central Neurofibromatosis
Neurofibromatosis, Central Type	Acoustic Schwannomas, Bilateral
Acoustic Neurinoma, Bilateral	Bilateral Acoustic Neurinoma
Bilateral Acoustic Schwannomas	Familial Acoustic Neuromas

Cockayne Syndrome A

Cockayne Syndrome Type 1	Cockayne Syndrome, Type A
Cockayne Syndrome Type I	CSA
Cockayne Syndrome Classic Form	Cockayne Syndrome Classical
Cockayne Syndrome Type A	Ckn1

Aicardi-Goutieres Syndrome

Aicardi Goutieres Syndrome	Cree Encephalitis
Aicardi-Goutières Syndrome	Encephalopathy With Basal Ganglia Calcification
Ags	Encephalopathy With Intracranial Calcification And Chronic Lymphocytosis Of Cerebrospinal Fluid
Pseudotoxoplasmosis Syndrome	Encephalopathy, Familial Infantile, With Calcification Of Basal Ganglia And Chronic Cerebrospinal Fluid Lymphocytosis
Familial Infantile Encephalopathy With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis	Aicardi-Goutieres Syndrome 1

Neurilemmoma

Schwannoma	Benign Schwannoma
Neurilemoma	Peripheral Fibroblastoma
Psammomatous Schwannoma	Neurolemmoma
Schwannomas

Lissencephaly

Pachygyria	Broad Gyri Of Cerebrum
Large Gyri Of Cerebrum	Macrogyria

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-149934	DCAF1 binder 1		99.12%	否
HY-156744	DBr-1	Degrader	/	否
HY-156746	DBt-10	Degrader	/	否
HY-149307	CYCA-117-70		/	否
HY-149935	OICR-8268		/	否
HY-156745	DDa-1	Degrader	/	否
HY-160876	BC-1901S	Activator	/	否
HY-169147	MY-11B		/	否
HY-169151	PROTAC BRD4-DCAF1 degrader-1		/	否
HY-169152	DCAF1 ligand 1		/	否
HY-RS03557	DCAF1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-156743	DCAF1 binder 2		/	否
HY-159777	CPI-203-PEG5-Alkyne		/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	DCAF1	VGNC	VGNC:71819
Canis familiaris	DCAF1	VGNC	VGNC:39788
Felis catus	DCAF1	VGNC	VGNC:61353
Mus musculus	DCAF1	MGD	MGI:2445220
Bos taurus	DCAF1	VGNC	VGNC:27899
Rattus norvegicus	DCAF1	RGD	RGD:1305176
Others	DCAF1	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

DCAF1 - DDB1 and CUL4 associated factor 1 Gene

关于 DCAF1

功能概要

DCAF1 基因产物(12)

DCAF1 蛋白互作信息

关联疾病

直系同源

热门区域

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DCAF1 - DDB1 and CUL4 associated factor 1 Gene

关于 DCAF1

功能概要

DCAF1 基因产物(12)

DCAF1 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z