2. Gene
  3. LATS2 - large tumor suppressor kinase 2 Gene

LATS2 - large tumor suppressor kinase 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：大肿瘤抑制激酶 2

种属: Homo sapiens

同用名: KPM

基因 ID: 26524 | 基因类型: protein coding

关于 LATS2

Cytogenetic location: 13q12.11 Genomic coordinates (GRCh38): 13:20,973,036-21,061,586 (from NCBI)

This gene has 2 transcripts (splice variants), 212 orthologues, 13 paralogues and is associated with 97 phenotypes. Ubiquitous expression in testis (RPKM 10.9), gall bladder (RPKM 10.1) and 25 other tissues.

功能概要

该基因编码属于 LATS 肿瘤抑制家族的丝氨酸/苏氨酸蛋白激酶。该蛋白质在间期、中期早期和晚期定位于中心体。它与中心体蛋白 aurora-A 和 ajuba 相互作用，是有丝分裂开始时γ-微管蛋白积累和纺锤体形成所必需的。它还与 p53 的负调节因子相互作用，并可能在与 p53 的正反馈回路中发挥作用，从而对细胞骨架损伤做出反应。此外，它还可以作为雄激素反应基因表达的共阻遏物发挥作用。[RefSeq 提供，2008 年 7 月]

This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to Cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression. [provided by RefSeq, Jul 2008]

LATS2 基因产物(1)

mRNA Protein Name
NM_014572.3 NP_055387.2 serine/threonine-protein kinase LATS2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ATP binding IDA
IDA: 通过直接分析推断
10871863 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16413547 GOA
enables protein serine/threonine kinase activity IDA
IDA: 通过直接分析推断
10871863 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in G1/S transition of mitotic cell cycle IDA
IDA: 通过直接分析推断
12853976 GOA
involved in hippo signaling IDA
IDA: 通过直接分析推断
20412773 GOA
involved in hormone-mediated signaling pathway IDA
IDA: 通过直接分析推断
15131260 GOA
involved in intracellular signal transduction IDA
IDA: 通过直接分析推断
10871863 GOA
involved in negative regulation of canonical Wnt signaling pathway IMP
IMP: 通过突变表型推断
20412773 GOA
involved in negative regulation of cyclin-dependent protein serine/threonine kinase activity IDA
IDA: 通过直接分析推断
12853976 GOA
involved in protein phosphorylation IDA
IDA: 通过直接分析推断
10871863 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in cytoplasm IDA
IDA: 通过直接分析推断
35429439 GOA
located in cytosol IDA
IDA: 通过直接分析推断
30865227 GOA
located in nucleus IDA
IDA: 通过直接分析推断
10673337 GOA
located in spindle pole IDA
IDA: 通过直接分析推断
12853976 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

LATS2 蛋白结构

Pkinase

Pkinase: Protein kinase domain (669 - 823)

Pkinase

Pkinase: Protein kinase domain (866 - 973)

Pkinase_C

Pkinase_C: Protein kinase C terminal domain (993 - 1045)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1088 a.a.
蛋白主名 其他名称

serine/threonine-protein kinase LATS2

LATS (large tumor suppressor, Drosophila) homolog 2

LATS2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra LATS2 Q9NRM7 MOB1B Homo sapiens Q7L9L4
Anti Tag CoIP
19739119
Intra LATS2 Q9NRM7 MOB1B Homo sapiens Q7L9L4
Pull Down
32707033
Intra LATS2 Q9NRM7 MOB1B Homo sapiens Q7L9L4
Pull Down
19739119
Intra LATS2 Q9NRM7 MOB1A Homo sapiens Q9H8S9
Anti Tag CoIP
33961781
Intra LATS2 Q9NRM7 MOB1A Homo sapiens Q9H8S9
Anti Tag CoIP
19739119
Intra LATS2 Q9NRM7 SIAH2 Homo sapiens O43255
Anti Bait CoIP
25438054
Intra LATS2 Q9NRM7 AJUBA Homo sapiens Q96IF1
Anti Tag CoIP
16413547
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Malignant Peritoneal Mesothelioma

Diffuse Malignant Peritoneal Mesothelioma

Primary Malignant Peritoneal Mesothelioma

Malignant Mesothelioma Of Peritoneum
Malignant Pleural Mesothelioma

Malignant Mesothelioma Of Pleura

Pleural Malignant Mesothelioma
Neurofibromatosis, Type Ii

Neurofibromatosis 2

Neurofibromatosis, Type 2

NF2

Neurofibromatosis Type Ii

Bilateral Acoustic Neurofibromatosis

Banf

Acn

Central Neurofibromatosis

Neurofibromatosis, Central Type

Acoustic Schwannomas, Bilateral

Acoustic Neurinoma, Bilateral

Bilateral Acoustic Neurinoma

Bilateral Acoustic Schwannomas

Familial Acoustic Neuromas
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon
Esophageal Cancer

Esophageal Carcinoma

Carcinoma Of Esophagus

Esophageal Squamous Cell Carcinoma, Somatic

Esophageal Carcinoma, Somatic

Esophagus Cancer

Gastric Cardia Adenocarcinoma

Esophageal Neoplasms

Esophageal Cancer, Somatic

Cancer Of Esophagus

Cancer Of Oesophagus

Carcinoma Of Oesophagus

Ca Lower Third Oesophagus

Ca Middle Third Oesophagus

Malignant Neoplasm Of Distal Third Of Esophagus

Malignant Neoplasm Of Lower Third Of Oesophagus

Malignant Neoplasm Of Middle Third Of Oesophagus

Malignant Neoplasm Of Proximal Third Of Esophagus

Malignant Neoplasm Of Upper Third Esophagus

Malignant Tumor Of Abdominal Esophagus

Malignant Tumor Of Distal Third Of Esophagus

Malignant Tumor Of Proximal Third Of Esophagus

Malignant Tumor Of The Middle Third Of The Esophagus

ESCR

Aerodigestive Tract Cancer

Escc

Esophageal Squamous Cell Carcinoma

Cancer, Esophageal

Malignant Neoplasm Of Esophagus

Squamous Cell Carcinoma Of Esophagus

Malignant Neoplasm Of Middle Third Of Esophagus
Anencephaly

Aprosencephaly

Anencephalus

Congenital Absence Of Brain

Absence Of A Large Part Of The Brain And The Skull

Anencephalia

Anencephalic Monster

Brain Absence

Brain Agenesis

Brain Aplasia

Absent Brain

Anencephalic

Congenital Absence Of Cerebrum

Congenital Hemicrania

Incomplete Anencephaly
Peritoneal Mesothelioma

Malignant Mesothelioma Of Peritoneum

Advanced Malignant Mesothelioma Of Peritoneum

Advanced Malignant Peritoneal Mesothelioma

Advanced Peritoneal Malignant Mesothelioma
Meningioma, Familial

Meningioma

Familial Meningioma

Meningioma, Familial, Susceptibility To

Meningeal Neoplasm

Meningeal Neoplasms

Meningiomas

Meningioma, Nf2-Related, Somatic

Meningioma, Sis-Related

Meningothelial Cell Tumor

Neoplasm Of The Meninges

Primary Meningeal Tumor

Familial Multiple Meningioma

MNGMA

Meningioma, Benign, No Icd-O Subtype

Intracranial Meningioma

Meningothelial Cell Neoplasm

Supratentorial Meningioma

Primary Neoplasm Of Spinal Meninges

Benign Intracranial Meningioma

Benign Meningioma

Meningeal Tumours

Meningeal Sarcoma Of Unspecified Site

Meningothelial Sarcoma Of Unspecified Site
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (7)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-138489 TRULI Modulator 99.98% 否
HY-147082 GA-017 Activator 98.92% 否
HY-147165 VT02956 Inhibitor 99.58% 否
HY-130504 Propargyl-PEG1-acid ≥97.0% 否
HY-RS07537 LAT2 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS07539 LATS2 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-147165A VT02956 hydrochloride Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus LATS2 VGNC VGNC:82443
Canis familiaris LATS2 VGNC VGNC:42599
Rattus norvegicus LATS2 RGD RGD:1305906
Macaca mulatta LATS2 VGNC VGNC:74239
Mus musculus LATS2 MGD MGI:1354386
Bos taurus LATS2 VGNC VGNC:30801
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