2. Gene
  3. AJUBA - ajuba LIM protein Gene

AJUBA - ajuba LIM protein Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：ajuba LIM 蛋白

种属: Homo sapiens

同用名: JUB

基因 ID: 84962 | 基因类型: protein coding

关于 AJUBA

Cytogenetic location: 14q11.2 Genomic coordinates (GRCh38): 14:22,971,177-22,982,551 (from NCBI)

This gene has 8 transcripts (splice variants), 171 orthologues and 2 paralogues. Broad expression in skin (RPKM 17.2), liver (RPKM 8.4) and 15 other tissues.

功能概要

启用 alpha-连环蛋白结合活性和转录辅阻遏物活性。参与多个过程，包括河马信号的负调控； miRNA 对基因沉默的正调控；和调节细胞对缺氧的反应。通过 miRNA 作用于基因沉默的上游或内部，并对含蛋白质的复合物组装进行正调控。位于多种细胞成分中，包括高尔基体； P 体；和核质。 [由基因组资源联盟提供，2022 年 4 月]

Enables alpha-catenin binding activity and transcription corepressor activity. Involved in several processes, including negative regulation of hippo signaling; positive regulation of gene silencing by miRNA; and regulation of cellular response to hypoxia. Acts upstream of or within gene silencing by miRNA and positive regulation of protein-containing complex assembly. Located in several cellular components, including Golgi apparatus; P-body; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

AJUBA 基因产物(3)

mRNA Protein Name
NM_001289097.2 NP_001276026.1 LIM domain-containing protein ajuba isoform 3
NM_032876.6 NP_116265.1 LIM domain-containing protein ajuba isoform 1
NM_198086.3 NP_932352.1 LIM domain-containing protein ajuba isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables alpha-catenin binding IDA
IDA: 通过直接分析推断
12417594 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
15778465 GOA
enables transcription corepressor activity IDA
IDA: 通过直接分析推断
18805794 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in miRNA-mediated gene silencing by inhibition of translation IMP
IMP: 通过突变表型推断
20616046 GOA
acts upstream of or within miRNA-mediated post-transcriptional gene silencing IMP
IMP: 通过突变表型推断
20616046 GOA
involved in negative regulation of hippo signaling IDA
IDA: 通过直接分析推断
20303269 GOA
acts upstream of or within positive regulation of protein-containing complex assembly IDA
IDA: 通过直接分析推断
15870274 GOA
involved in regulation of cellular response to hypoxia IDA
IDA: 通过直接分析推断
22286099 GOA
involved in response to hypoxia IDA
IDA: 通过直接分析推断
22286099 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in P-body IDA
IDA: 通过直接分析推断
20616046 GOA
located in cell-cell junction IDA
IDA: 通过直接分析推断
12417594 GOA
located in nucleus IDA
IDA: 通过直接分析推断
18805794 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

AJUBA 蛋白结构

LIM

LIM: LIM domain (338 - 392)

LIM

LIM: LIM domain (403 - 458)

LIM

LIM: LIM domain (463 - 527)

  • 0
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  • 500
  • 538 a.a.
蛋白主名 其他名称

LIM domain-containing protein ajuba

jub, ajuba homolog

AJUBA 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
AJUBA Q96IF1 ZNF512B Homo sapiens Q96KM6
Validated Y2H
32296183
种属内
AJUBA Q96IF1 TSG101 Homo sapiens Q99816
Validated Y2H
32296183
种属内
AJUBA Q96IF1 LATS2 Homo sapiens Q9NRM7
Anti Tag CoIP
33961781
种属内
AJUBA Q96IF1 LATS2 Homo sapiens Q9NRM7
Y2H
16413547
种属内
AJUBA Q96IF1 LATS2 Homo sapiens Q9NRM7
Anti Bait CoIP
16413547
种属内
AJUBA Q96IF1 LATS2 Homo sapiens Q9NRM7
Pull Down
16413547
种属内
AJUBA Q96IF1 ZNF541 Homo sapiens Q9H0D2
Validated Y2H
32296183
种属内
AJUBA Q96IF1 TEKT3 Homo sapiens Q9BXF9
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Squamous Cell Carcinoma

Epidermoid Carcinoma

Squamous Cell Cancer

Carcinoma, Squamous Cell

Squamous Cell Skin Cancer

Malignant Squamous Cell Tumor

Squamous Carcinoma

Squamous Cell Epithelioma

Carcinoma Squamous Cell

Neoplasms, Squamous Cell

Squamous Cell Carcinoma - Category

Malignant Squamous Cell Neoplasm

Squamous Cell Carcinoma Of Skin
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00504 AJUBA Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus AJUBA RGD RGD:620407
Mus musculus AJUBA MGD MGI:1341886
Felis catus AJUBA VGNC VGNC:80777
Bos taurus AJUBA VGNC VGNC:25769
Macaca mulatta AJUBA VGNC VGNC:69645
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