CCAR1 - cell division cycle and apoptosis regulator 1 Gene

中文名称：细胞分裂周期和凋亡调节因子 1

种属: Homo sapiens

基因 ID: 55749 | 基因类型: protein coding

关于 CCAR1

Cytogenetic location: 10q21.3 Genomic coordinates (GRCh38): 10:68,721,239-68,792,377 (from NCBI)

This gene has 18 transcripts (splice variants), 212 orthologues and 1 paralogue. Ubiquitous expression in lymph node (RPKM 17.5), appendix (RPKM 15.2) and 25 other tissues.

功能概要

启用 RNA 聚合酶 II 顺式调节区序列特异性 DNA 结合活性；核受体共激活因子活性；和转录辅阻遏物活性。参与细胞迁移的正向调节和细胞群增殖的正向调节。在细胞凋亡过程的正调控上游或正调控中起作用。位于核膜腔内。 [由基因组资源联盟提供，2022 年 4 月]

Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; nuclear receptor coactivator activity; and transcription corepressor activity. Involved in positive regulation of cell migration and positive regulation of cell population proliferation. Acts upstream of or within positive regulation of apoptotic process. Located in nuclear envelope lumen. [provided by Alliance of Genome Resources, Apr 2022]

CCAR1 基因产物(3)

mRNA	Protein	Name
NM_001282959.2	NP_001269888.1	cell division cycle and apoptosis regulator protein 1 isoform b
NM_001282960.2	NP_001269889.1	cell division cycle and apoptosis regulator protein 1 isoform b
NM_018237.4	NP_060707.2	cell division cycle and apoptosis regulator protein 1 isoform a

CCAR1 蛋白结构

S1-like

DBC1

SAP

0
200
400
600
800
1000
1150 a.a.

蛋白主名

其他名称

cell division cycle and apoptosis regulator protein 1

cell cycle and apoptosis regulatory protein 1

CCAR1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	CCAR1	Q8IX12	DNAAF6	Homo sapiens	Q9NQM4	Y2H Prey Pooling	25416956
种属内	CCAR1	Q8IX12	MTUS2	Homo sapiens	Q5JR59-3	Y2H Array	32296183
种属内	CCAR1	Q8IX12	MTUS2	Homo sapiens	Q5JR59-3	Y2H Prey Pooling	32296183
种属内	CCAR1	Q8IX12	TRIM63	Homo sapiens	Q969Q1	Y2H	18157088
种属内	CCAR1	Q8IX12	TRIM63	Homo sapiens	Q969Q1	Pull Down	18157088
种属内	CCAR1	Q8IX12	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	25416956
种属内	CCAR1	Q8IX12	GOLGA2	Homo sapiens	Q08379	Validated Y2H	25416956
种属内	CCAR1	Q8IX12	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	32296183
种属内	CCAR1	Q8IX12	GOLGA2	Homo sapiens	Q08379	Y2H Array	32296183
种属内	CCAR1	Q8IX12	WWTR1	Homo sapiens	Q9GZV5	Anti Bait CoIP	20594350

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Drug-Induced Lupus Erythematosus

Dile	Dil
Drug-Induced Systemic Lupus Erythematosus

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-119331	CFM-5	Inducer	/	否
HY-RS02020	CCAR1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	CCAR1	RGD	RGD:1560358
Mus musculus	CCAR1	MGD	MGI:1914750
Felis catus	CCAR1	VGNC	VGNC:60442
Bos taurus	CCAR1	VGNC	VGNC:106671
Macaca mulatta	CCAR1	VGNC	VGNC:97743
Canis familiaris	CCAR1	VGNC	VGNC:38773

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