TRIM63 - tripartite motif containing 63 Gene

中文名称：含三方基序 63

种属: Homo sapiens

同用名: IRF; SMRZ; MURF1; MURF2; RNF28

基因 ID: 84676 | 基因类型: protein coding

关于 TRIM63

Cytogenetic location: 1p36.11 Genomic coordinates (GRCh38): 1:26,051,301-26,067,630 (from NCBI)

This gene has 2 transcripts (splice variants), 139 orthologues and 80 paralogues. Biased expression in heart (RPKM 44.7) and esophagus (RPKM 2.8).

功能概要

该基因编码在横纹肌和虹膜中发现的 RING 锌指蛋白家族成员。该基因的产物是一种 E3 泛素连接酶，定位于肌原纤维的 Z 线和 M 线格。这种蛋白质在骨骼肌和心肌的萎缩中起重要作用，并且是肌球蛋白重链蛋白、肌球蛋白轻链、肌球蛋白结合蛋白和肌肉型肌酸激酶降解所必需的。[RefSeq 提供，2012 年 2 月]

This gene encodes a member of the RING zinc finger protein family found in striated muscle and iris. The product of this gene is an E3 ubiquitin Ligase that localizes to the Z-line and M-line lattices of myofibrils. This protein plays an important role in the atrophy of skeletal and cardiac muscle and is required for the degradation of Myosin heavy chain proteins, Myosin light chain, Myosin binding protein, and for muscle-type creatine kinase. [provided by RefSeq, Feb 2012]

TRIM63 基因产物(1)

mRNA	Protein	Name
NM_032588.4	NP_115977.2	E3 ubiquitin-protein ligase TRIM63

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	18157088	GOA
enables titin binding	IDA IDA: 通过直接分析推断	11927605	GOA
enables ubiquitin protein ligase activity	IDA IDA: 通过直接分析推断	34244144	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in negative regulation of glycolytic process	IMP IMP: 通过突变表型推断	34244144	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	11927605	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TRIM63 蛋白结构

zf-C3HC4_2

zf-B_box

0
100
200
300
353 a.a.

蛋白主名

其他名称

E3 ubiquitin-protein ligase TRIM63

RING-type E3 ubiquitin transferase TRIM63

TRIM63 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	TRIM63	Q969Q1	TTN	Homo sapiens	Q8WZ42	Y2H	18157088
种属内	TRIM63	Q969Q1	TTN	Homo sapiens	Q8WZ42	Y2H Fragment Pooling	23414517
种属内	TRIM63	Q969Q1	USP13	Homo sapiens	Q92995	Y2H Prey Pooling	31391242
种属内	TRIM63	Q969Q1	USP13	Homo sapiens	Q92995	Anti Tag CoIP	31391242
种属内	TRIM63	Q969Q1	DCAF8	Homo sapiens	Q5TAQ9	IF	31391242
种属内	TRIM63	Q969Q1	DCAF8	Homo sapiens	Q5TAQ9	Anti Tag CoIP	31391242
种属内	TRIM63	Q969Q1	MYOZ1	Homo sapiens	Q9NP98	Y2H	18157088
种属内	TRIM63	Q969Q1	MRPL41	Homo sapiens	Q8IXM3	Y2H	18157088

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Hypertrophic Cardiomyopathy

Hypertrophic Obstructive Cardiomyopathy	Cardiomyopathy, Hypertrophic
Cardiomyopathy Hypertrophic Obstructive	Cardiomyopathy, Hypertrophic, Familial
Idiopathic Myocardial Hypertrophy	Idiopathic Hypertrophic Cardiomyopathy
Obstructive Idiopathic Hypertrophic Cardiomyopathy	Obstructive Cardiomyopathy
Idiopathic Hypertrophic Subaortic Stenosis	Muscular Subaortic Stenosis
Hypertrophic Obstructive Subaortic Stenosis

Muscular Atrophy

Muscle Wasting	Amyotrophia
Wasting - Muscle	Skeletal Muscle Atrophy

Myopathy, Myofibrillar, 9, With Early Respiratory Failure

Hereditary Myopathy With Early Respiratory Failure	Hmerf
Myopathy, Proximal, With Early Respiratory Muscle Involvement	Edstrom Myopathy
Mfm-Titinopathy	MFM9
Mprm	Hereditary Inclusion Body Myopathy With Early Respiratory Failure
Hibm-Erf	Myofibrillar Myopathy-Titinopathy
Myofibrillar Myopathy With Early Respiratory Failure	Myopathy, Distal, With Early Respiratory Failure, Autosomal Dominant
Myofibrillar Myopathy 9	Myofibrillar Myopathy 9 With Early Respiratory Failure
Autosomal Dominant Distal Myopathy With Early Respiratory Failure	Proximal Myopathy With Early Respiratory Muscle Involvement
Hereditary Proximal Myopathy With Early Respiratory Failure	Admerf
Edström Myopathy	Hmerf-Erf

Hyaline Body Myopathy

Myosin Storage Myopathy	Autosomal Dominant Hyaline Body Myopathy
Myopathy, Myosin Storage

Muscle Tissue Disease

Critical Illness Polyneuropathy

Polyneuropathy, Critical Illness

Muscular Disease

Viral Infectious Disease

Viral Disease	Arbovirus Infections
Virus Infection	Virus Diseases
Viral Infection	Viral Infections
Virus Infections

Ullrich Congenital Muscular Dystrophy 1

Ullrich Congenital Muscular Dystrophy	Ullrich Disease
Ucmd	Ullrich Scleroatonic Muscular Dystrophy
Scleroatonic Muscular Dystrophy	UCMD1
Muscular Dystrophy, Limb-Girdle, Autosomal Recessive 22	Lgmdr22
Muscular Dystrophy, Scleroatonic	Late Onset Scleroatonic Familial Myopathy
Congenital Muscular Dystrophy, Ullrich Type

Myofibrillar Myopathy

Desmin Related Myopathy	Myotilinopathy
Myopathy, Myofibrillar	Alpha Beta Crystallinopathy
Desmin Storage Myopathy	Desminopathy
Filaminopathy	Protein Surplus Myopathy
Zaspopathy	Myofibrillar Myopathies
Myopathy, Myofibrillar, Desmin-Related	Myopathy, Desmin Storage
Mfm - [Myofibrillar Myopathy]

Autosomal Recessive Limb-Girdle Muscular Dystrophy

Muscular Dystrophy, Limb-Girdle, Autosomal Recessive

Myopathy

Muscular Diseases

Myopathies

Cardiomyopathy, Familial Hypertrophic, 1

Asymmetric Septal Hypertrophy	Familial Hypertrophic Cardiomyopathy
Hypertrophic Cardiomyopathy 1	CMH1
Hypertrophic Cardiomyopathy 19	CMH
Ventricular Hypertrophy, Hereditary	Ash
Hypertrophic Subaortic Stenosis, Idiopathic	Cardiomyopathy, Familial Hypertrophic
Cardiomyopathy, Hypertrophic, 1, Digenic	Cardiomyopathy, Familial Hypertrophic 1
Hcm	Hereditary Ventricular Hypertrophy
Idiopathic Hypertrophic Subaortic Stenosis	Hypertrophic Cardiomyopathy
Cardiomyopathy, Hypertrophic, Familial	Cardiomyopathy, Hypertrophic, 1
Familial Asymmetric Septal Hypertrophy	Heritable Hypertrophic Cardiomyopathy
Fhc	Cardiomyopathy, Hypertrophic, Familial, Type 1

Dilated Cardiomyopathy

Familial Dilated Cardiomyopathy	Primary Dilated Cardiomyopathy
Idiopathic Dilated Cardiomyopathy	Congestive Cardiomyopathy
Idiopathic Dilation Cardiomyopathy	Primary Familial Dilated Cardiomyopathy
Cardiomyopathy, Dilated	DCM
Cardiomyopathy, Familial Dilated	Dilated Cardiomyopathy, Familial
Hypokinetic Dilated Cardiomyopathy, Familial	Familial Idiopathic Cardiomyopathy
Fdc	Cardiomyopathy, Familial Idiopathic
Idiopathic Cardiomegaly	Dilated Congestive Cardiomyopathy
Chronic Dilated Cardiomyopathy	Ccm - [Congestive Cardiomyopathy]
Cocm - [Congestive Cardiomyopathy]	Dcm - [Dilated Cardiomyopathy]
Dilated-Hypokinetic Cardiomyopathy	Congestive Idiopathic Cardiomyopathy
Primary Idiopathic Dilated Cardiomyopathy

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS15063	TRIM63 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	TRIM63	MGD	MGI:2447992
Rattus norvegicus	TRIM63	RGD	RGD:619964
Canis familiaris	TRIM63	VGNC	VGNC:47831
Macaca mulatta	TRIM63	VGNC	VGNC:79002
Felis catus	TRIM63	VGNC	VGNC:66548
Bos taurus	TRIM63	VGNC	VGNC:36346

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

TRIM63 - tripartite motif containing 63 Gene

关于 TRIM63

功能概要

TRIM63 基因产物(1)

TRIM63 蛋白结构

TRIM63 蛋白互作信息

关联疾病

直系同源

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TRIM63 - tripartite motif containing 63 Gene

关于 TRIM63

功能概要

TRIM63 基因产物(1)

TRIM63 蛋白结构

TRIM63 蛋白互作信息

关联疾病

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直系同源

热门区域

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F

G

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J

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